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3235-69-6

Basic Information
CAS No.: 3235-69-6
Name: MORPHOLIN-4-YL-ACETIC ACID
Article Data: 32
Molecular Structure:
Molecular Structure of 3235-69-6 (MORPHOLIN-4-YL-ACETIC ACID)
Formula: C6H11NO3
Molecular Weight: 145.158
Synonyms: 2-(4-Morpholinyl)aceticacid;2-(Morpholino)acetic acid;Morpholinoacetic acid;N-(Carboxymethyl)morpholine;
Density: 1.202 g/cm3
Melting Point: 162-164 °C
Boiling Point: 271.898 °C at 760 mmHg
Flash Point: 118.24 °C
Hazard Symbols: IrritantXi
Risk Codes: 36
PSA: 49.77000
LogP: -0.65890
Synthetic route
88217-68-9

(4-morpholinyl)acetic acid 1,1-dimethylethyl ester

3235-69-6

morpholin-4-ylacetic acid

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.5h; Hydrolysis;100%
In water; isopropyl alcohol at 160℃; for 0.4h; Solvent; Temperature; Flow reactor;95%
With trifluoroacetic acid In dichloromethane at 20℃; for 5h;
53342-23-7

benzyl morpholino-acetate

3235-69-6

morpholin-4-ylacetic acid

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol for 40h;98%
With potassium tert-butylate In tetrahydrofuran at 0℃; for 5h; Hydrolysis;97%
3235-82-3

N-morpholylacetic acid ethyl ester

3235-69-6

morpholin-4-ylacetic acid

Conditions
ConditionsYield
With hydrogenchloride In water at 95℃; for 16h; Temperature; Time;96.3%
With water for 30h; Hydrolysis; Heating;87%
With sodium hydroxide In water Heating;65%
35855-10-8

methyl 2-morpholin-4-ylacetate

3235-69-6

morpholin-4-ylacetic acid

Conditions
ConditionsYield
Stage #1: methyl 2-morpholin-4-ylacetate With methanol; sodium hydroxide; water In tetrahydrofuran at 50℃; for 1h;
Stage #2: With hydrogenchloride In tetrahydrofuran; water pH=3;
90%
With water; lithium hydroxide In methanol at 20℃; for 3h; Inert atmosphere;
110-91-8

morpholine

79-08-3

bromoacetic acid

3235-69-6

morpholin-4-ylacetic acid

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;85.3%
110-91-8

morpholine

5292-43-3

bromoacetic acid tert-butyl ester

3235-69-6

morpholin-4-ylacetic acid

Conditions
ConditionsYield
In tetrahydrofuran; hydrogenchloride; ethyl acetate85%
In tetrahydrofuran; hydrogenchloride; ethyl acetate85%
110-91-8

morpholine

5625-90-1

4-(morpholinomethyl)morpholine

151-50-8

potassium cyanide

3235-69-6

morpholin-4-ylacetic acid

Conditions
ConditionsYield
With water
110-91-8

morpholine

3926-62-3

sodium monochloroacetic acid

3235-69-6

morpholin-4-ylacetic acid

Conditions
ConditionsYield
With water

5-(2-morpholinoacetamido)-3,3-di-p-tolyl-2-indolinone hydrochloride

A

3235-69-6

morpholin-4-ylacetic acid

B

5-Amino-3,3-di-p-tolyl-1,3-dihydro-indol-2-one

Conditions
ConditionsYield
With hydrogenchloride; water In acetic acid at 69.9 - 95.9℃; Rate constant; Kinetics; Thermodynamic data; ΔS(activ.), ΔH(activ.), ΔG(activ.);
110-91-8

morpholine

105-39-5

chloroacetic acid ethyl ester

3235-69-6

morpholin-4-ylacetic acid

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane; benzene
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Chemistry


Molecular Formula: C6H11NO3
Molecular Weight: 145.16 g/mol
Canonical SMILES: O=C(O)CN1CCOCC1
InChI: InChI=1/C6H11NO3/c8-6(9)5-7-1-3-10-4-2-7/h1-5H2,(H,8,9)
Mol File: 3235-69-6.mol
Product Categories: Amino Acids and Derivatives
Nominal Mass: 145
Average Mass: 145.1564
Monoisotopic Mass: 145.073893
H bond acceptors: 4
H bond donors: 1
#Freely Rotating Bonds: 2
Polar Surface Area: 38.77
Index of Refraction: 1.483
Molar Refractivity: 34.5 cm3
Molar Volume: 120.7 cm3
Polarizability: 13.68×10-24cm3
Surface Tension: 43.1 dyne/cm
Density: 1.202 g/cm3
Flash Point: 118.2 °C
Enthalpy of Vaporization: 56.15 kJ/mol
Boiling Point: 271.9 °C at 760 mmHg
Vapour Pressure of 4-Morpholineacetic acid (CAS NO.3235-69-6): 0.00175 mmHg at 25 °C

Safety Profile

Hazard Codes: IrritantXi
HazardClass of 4-Morpholineacetic acid (CAS NO.3235-69-6): Irritant

Specification

 4-Morpholineacetic acid (CAS NO.3235-69-6), its synonyms are 2-(4-Morpholinyl)acetic acid ;
Morpholineacetic acid ; Morpholin-4-yl-acetic acid ; 4-Morpholine acetic acid .