CAS No.3240-94-6,4-(2-Chloroethyl)morpholine Suppliers

Products Categories

Pharmaceutical (33)
Organic Chemicals (15)
Others (10)
Reagent (5)
Materials (1)

Basic Information

Molecular Structure:
CAS No.:	3240-94-6
Name:	4-(2-Chloroethyl)morpholine
Article Data:	37

Formula:	C₆H₁₂ClNO
Molecular Weight:	149.62
Synonyms:	1-Chloro-2-morpholinoethane;1-Morpholino-2-chloroethane;2-(4-Morpholinyl)ethyl chloride;2-Morpholino-1-chloroethane;2-Morpholinoethyl chloride;4-(2-Chloroethyl)morpholine;Morpholinoethyl chloride;N-(2-Chloroethyl)morpholine;N-(Chloroethyl)morpholine;b-Chloroethylmorpholine;b-Morpholinoethyl chloride;
EINECS:	221-810-2
Density:	1.088 g/cm³
Boiling Point:	202.8 °C at 760 mmHg
Flash Point:	76.4 °C
PSA:	12.47000
LogP:	1.29730

Synthetic route

: 622-40-2
2-(morpholin-4-yl)ethanol

: 3240-94-6
N-(2-chlorethyl)morpholine

Conditions

Conditions	Yield
With thionyl chloride In toluene at 0℃; for 10h; Reflux;	89%
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 0 - 40℃;	74%
With thionyl chloride In dichloromethane at 0 - 40℃;	43.85%

: 3647-69-6
4-(2-chloroethyl)morpholine hydrochride

: 3240-94-6
N-(2-chlorethyl)morpholine

Conditions

Conditions	Yield
With potassium carbonate In water	84%
With potassium carbonate In water	69%
With potassium hydroxide In water	59%

: 110-91-8
morpholine

: 107-06-2
1,2-dichloro-ethane

A: 3240-94-6
N-(2-chlorethyl)morpholine

B: 1723-94-0
1,2-dimorpholylethane

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 70 - 80℃; for 2.5h;	A 30% B 22%

...Expand

: 110-91-8
morpholine

: 107-04-0
1-Bromo-2-chloroethane

: 3240-94-6
N-(2-chlorethyl)morpholine

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃;	20%
With potassium carbonate In acetonitrile at 20℃;

: 186581-53-3, 908094-01-9
diazomethane

: 16158-87-5
N-(chloromethyl)morpholine

: 3240-94-6
N-(2-chlorethyl)morpholine

: 110-91-8
morpholine

: 107-20-0
2-chloroethanal

: 3240-94-6
N-(2-chlorethyl)morpholine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane; water for 2h; Ambient temperature;

whose hydrochloride: whose hydrochloride

: 3240-94-6
N-(2-chlorethyl)morpholine

Conditions

Conditions	Yield
With thionyl chloride; chloroform
With thionyl chloride; benzene
With tetrachloromethane; thionyl chloride

: 5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one

A: 3240-94-6
N-(2-chlorethyl)morpholine

B: 519015-10-2
2-morpholinoethyl-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one

: 110-91-8
morpholine

: 540-51-2
2-bromoethanol

: 3240-94-6
N-(2-chlorethyl)morpholine

Conditions

Conditions	Yield
Stage #1: morpholine; 2-bromoethanol With triethylamine In toluene at 80℃; for 4h; Stage #2: With thionyl chloride In dichloromethane at 0 - 80℃; for 2h;
Stage #1: morpholine; 2-bromoethanol With potassium carbonate In acetonitrile at 75℃; for 16h; Stage #2: With thionyl chloride; 1,2-dichloro-ethane In 1,2-dichloro-ethane at 80℃; for 16h;

: 3240-94-6
N-(2-chlorethyl)morpholine

: 1687-53-2
5-amino-2-methoxyphenol

: 170229-80-8
4-methoxy-3-(2-morpholinoethoxy)aniline

Conditions

Conditions	Yield
In pyridine; DMF (N,N-dimethyl-formamide) at 20 - 60℃;	100%

Total:60 Page 1 of 2 1 2 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 3240-94-6

Specification

The IUPAC name of this chemical is 4-(2-chloroethyl)morpholine. With the CAS registry number 3240-94-6 and EINECS 221-810-2, it is also named as 2-(4-Morpholinyl)ethyl chloride. The classification codes are Drug / Therapeutic Agent; Mutation data; TSCA Flag P [A commenced PMN (Premanufacture Notice) substance]. This chemical is highly toxic. When heated to decomposition it emits toxic fumes of Cl⁻ and NO_x. So the storage environment should be well-ventilated, low-temperature and dry. Keep 4-(2-Chloroethyl)morpholine separate from raw materials of food.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 0.27; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.93; (4)ACD/LogD (pH 7.4): 0.19; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 2.1; (8)ACD/KOC (pH 7.4): 28.02; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.461; (13)Molar Refractivity: 37.79 cm³; (14)Molar Volume: 137.5 cm³; (15)Polarizability: 14.98×10^-24 cm³; (16)Surface Tension: 31.6 dyne/cm; (17)Enthalpy of Vaporization: 43.9 kJ/mol; (18)Vapour Pressure: 0.288 mmHg at 25°C; (19)Rotatable Bond Count: 2; (20)Exact Mass: 149.060742; (21)MonoIsotopic Mass: 149.060742; (22)Topological Polar Surface Area: 12.5; (23)Heavy Atom Count: 9; (24)Complexity: 73.5.

Uses of 4-(2-Chloroethyl)morpholine: It can react with 2-morpholin-4-yl-ethanol to get 4,4'-(3-oxa-pentane-1,5-diyl)-bis-morpholine. This reaction needs reagent 50percent NaOH, catalytic agent Adogen 464 and solvent tetrahydrofuran by heating. The reaction time is 6 hours. The yield is 84%.

People can use the following data to convert to the molecule structure.
1. SMILES:ClCCN1CCOCC1
2. InChI:InChI=1/C6H12ClNO/c7-1-2-8-3-5-9-6-4-8/h1-6H2
3. InChIKey:ZAPMTSHEXFEPSD-UHFFFAOYAJ

The following are the toxicity data which has been tested.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LCLo	inhalation	370mg/m³/10M (370mg/m³)		National Defense Research Committee, Office of Scientific Research and Development, Progress Report.Vol. NDCrc-132, Pg. NOV1942,
rat	LD50	unreported	70mg/kg (70mg/kg)		Pharmaceutical Bulletin. Vol. 1, Pg. 297, 1953.