CAS No.328-38-1,D-2-Amino-4-methylpentanoic acid Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	328-38-1
Name:	D-2-Amino-4-methylpentanoic acid
Article Data:	115

Formula:	C₆H₁₃NO₂
Molecular Weight:	131.175
Synonyms:	(R)-(-)-Leucine;(R)-Leucine;D-2-Amino-4-methylvaleric acid;Leucine,d;D-Leuzin;Leucine, D-;(2R)-2-amino-4-methylpentanoic acid;H-D-Leu-OH;D-2-Amino-4-methylpentanoic acid;
EINECS:	206-327-7
Density:	1.035 g/cm³
Melting Point:	300 ºC
Boiling Point:	225.8 ºC at 760 mmHg
Flash Point:	90.3 ºC
Solubility:	24 g/L (25 ºC)
Appearance:	white crystals
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	22-24/25-36-26
PSA:	63.32000
LogP:	1.14470

Synthetic route

: 35661-60-0, 126727-03-5, 114360-54-2
N-(9-fluorenylmethoxycarbonyl)-D-leucine

: 328-38-1
(R)-leucine

Conditions

Conditions	Yield
With piperidine In N,N-dimethyl-formamide at 20℃;	100%

: 89384-51-0
(R)-N-benzylleucine

: 328-38-1
(R)-leucine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In acetic acid for 24h;	98%

: 126191-08-0
(R)-2-azido-4-methylpentanoic acid

: 328-38-1
(R)-leucine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In water; acetic acid under 760 Torr; for 4h;	92%

: 24292-07-7
D-α-Hydrazino-isocapronsaeure

: 328-38-1
(R)-leucine

Conditions

Conditions	Yield
With hydrogen; platinum(IV) oxide	91%

: 170642-24-7
(R)-2-Amino-4-methyl-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

A: 328-38-1
(R)-leucine

B: 90-82-4
pseudoephedrine

Conditions

Conditions	Yield
With water for 10h; Heating;	A 86% B n/a

: 170642-24-7
(R)-2-Amino-4-methyl-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

: 328-38-1
(R)-leucine

Conditions

Conditions	Yield
In water for 10h; Heating; other reagent;	86%

: 816-66-0
4-methyl-2-oxopentanoic acid

: 328-38-1
(R)-leucine

Conditions

Conditions	Yield
With D-glucose; Bacillus subtilis glucose dehydrogenase; Symbiobacterium thermophilum meso-Diaminopimelate dehydrogenase W121L/H227I mutant; NADP; ammonium chloride In aq. buffer at 37℃; for 24h; pH=8.5; Kinetics; Reagent/catalyst; Enzymatic reaction;	68%
With D-Alanine; meso-diaminopimelate dehydrogenase; pyridoxal 5'-phosphate; alcohol dehydrogenases from Bacillus stearothermophilus; alcohol dehydrogenases from Thermoanaerobacter brockii; NADH In isopropyl alcohol at 35℃; for 12h; pH=8; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;	53.2%
With meso-2,6-D-diaminopimelic acid dehydrogenase mutant BC621; ammonium chloride; NADPH In various solvent(s) for 24h;
With D-amino acid transaminase; D-Alanine; R-selective ω-transaminase from Arthrobacter sp; (3-hydroxy-5-hydroxymethyl)-2-methylisonicotinic acid 5-phosphate; isopropylamine In aq. phosphate buffer for 7h; pH=7;	n/a
With D-Glucose; Bacillus megaterium glucose dehydrogenase; ammonia; Symbiobacterium thermophilum mesodiaminopimelate dehydrogenase Enzymatic reaction;	n/a

: 4502-00-5
sodium 4-methyl-2-oxovalerate

: 328-38-1
(R)-leucine

Conditions

Conditions	Yield
With zinc(II) perchlorate; (S)-15-amino-methyl-14-hydroxy-5,5-dimethyl-2,8-dithia<9>(2,5)pyridinophane In methanol for 24h; Ambient temperature;	66%

: 328-39-2
LEUCINE

: 328-38-1
(R)-leucine

Conditions

Conditions	Yield
With yeast; Sucrose
beim Durchgang durch den Organismus des Kaninchens;
With penicillium glaucum

: 2899-43-6
DL-leucine ethyl ester

: 328-38-1
(R)-leucine

Conditions

Conditions	Yield
With (-)-(R,R)-dibenzoyltartaric acid

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Consensus Reports

Reported in EPA TSCA Inventory.

Specification

The D-Leucine, with the cas register number 328-38-1, has its IUPAC name of 2-amino-4-methylpentanoic acid. This is a kind of flaky crystalline powder, and soluble in water, acetic acid, slightly soluble in ethanol, and insoluble in diethyl [ethyl] ether. The product categories are including leucine [leu, l]; amino acids and derivatives; alpha-amino acids; amino acids; biochemistry; amino acids. It should be kept in the storage temp. -15°C. Besides, it is usually applied in biochemical study.

The physical properties of this chemical could be summarized as: (1)ACD/LogP: 0.73; (2)# of Rule of 5 Violations: 0; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 1; (6)ACD/KOC (pH 7.4): 1; (7)#H bond acceptors: 3; (8)#H bond donors: 3; (9)#Freely Rotating Bonds: 4; (10)Polar Surface Area: 29.54; (11)Index of Refraction: 1.462; (12)Molar Refractivity: 34.86 cm³; (13)Molar Volume: 126.6 cm³; (14)Polarizability: 13.82 ×10^-24cm³; (15)Surface Tension: 39 dyne/cm; (16)Density: 1.035 g/cm³; (17)Flash Point: 90.3 °C; (18)Enthalpy of Vaporization: 50.93 kJ/mol; (19)Boiling Point: 225.8 °C at 760 mmHg; (20)Vapour Pressure: 0.0309 mmHg at 25°C.

As to its production method, please follow the below ways. Firstly, prepare the raw material of acetyl-DL-leucine, and go through the acylase treatment to remove L-leucine, and then hydrolyze in hydrochloric [chlorhydric] acid to get the crude products; Lastly, have the crystalline purification to get the puregrade.

When you are using this chemical, you should be very cautious. Being a kind of irritant chemical, it is irritating to eyes, respiratory system and skin, and may cause inflammation to the skin or other mucous membranes. So while dealing with this chemical, you should take the following instructions. Wear suitable protective clothing. Do not breathe dust and avoid contacting with skin and eyes. And if in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice. You could also refer to WGK Germany 3 to obtain more safety information.

Additionally, you could convert the following datas information into the molecular structure:
(1)Canonical SMILES: CC(C)CC(C(=O)O)N
(2)InChI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)
(3)InChIKey: ROHFNLRQFUQHCH-UHFFFAOYSA-N

Below are the toxcity information of this chemical:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LD50	intraperitoneal	6429mg/kg (6429mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archives of Biochemistry and Biophysics. Vol. 64, Pg. 319, 1956.

Organism

Test Type

Route

Reported Dose (Normalized Dose)

Effect

Source

rat

LD50

intraperitoneal

6429mg/kg (6429mg/kg)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

Archives of Biochemistry and Biophysics. Vol. 64, Pg. 319, 1956.

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