CAS No.32986-56-4,Tobramycin Suppliers

Products Categories

Pharmaceutical (186)
Others (41)
Organic Chemicals (31)
Reagent (9)
Plant Extract (3)
Basic Inorganic Chemicals (1)
Materials (1)

Basic Information

Molecular Structure:
CAS No.:	32986-56-4
Name:	Tobramycin
Article Data:	10

Formula:	C₁₈H₃₇N₅O₉
Molecular Weight:	467.52
Synonyms:	D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1-4))-2-deoxy- ; Deoxykanamycin B ; Gotabiotic ; Nebramycin ; O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1-6))-2-deoxy-L-streptamine;O-3-Amino-3-deoxy-alpha-D-lucopyranosyl-(1-6)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ibohexopyranosyl-(1-4))-2-deoxy-D-streptamine;Tobamycin Base;Sulfate sterile;
EINECS:	251-322-5
Density:	1.52 g/cm³
Melting Point:	178 °C
Boiling Point:	775.436 °C at 760 mmHg
Flash Point:	422.8 °C
Solubility:	50 mg/mL in water
Appearance:	White powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-37/39
PSA:	268.17000
LogP:	-2.79430

Synthetic route

: 23155-02-4
fosfomycin

: 32986-56-4
tobramycin

: tobramycin sulfate

: 32986-56-4
tobramycin

Conditions

Conditions	Yield
Stage #1: tobramycin sulfate Stage #2: With trifluoroacetic acid In water

: 32986-56-4
tobramycin

: 207857-15-6
1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine

: guanidinoboc10-tobramycin

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water at 20℃; for 72h;	100%

: 32986-56-4
tobramycin

: 207857-15-6
1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine

: 290360-48-4
C73H127N15O29

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water at 20℃; for 72h;	100%

: 32986-56-4
tobramycin

: 468065-22-7
O-3-azido-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diazido-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-1,3-diazido-1,2,3-trideoxy-D-myo-inositol

Conditions

Conditions	Yield
With TEA; triflic azide; copper(II) sulfate In methanol; dichloromethane	100%
With triflic azide; triethylamine; zinc(II) chloride In methanol; dichloromethane; water at 20℃;	92%
With triflic azide; copper(II) sulfate; triethylamine	83%
With triflic azide; triethylamine; zinc(II) chloride In methanol; dichloromethane; water Inert atmosphere;
With triflic azide; zinc(II) chloride In methanol; dichloromethane; water Inert atmosphere;

: 32986-56-4
tobramycin

: 24424-99-5
di-tert-butyl dicarbonate

: 172950-21-9
di-tert-butyl ((1S,3R,4S,5S,6R)-4-(((2S,3R,4S,5S,6R)-4-((tert-butoxycarbonyl)amino)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,3R,5S,6R)-3-((tert-butoxycarbonyl)amino)-6-(((tert-butoxycarbonyl)methyl)-5-hydroxytetrahydro-2H-pyran-2-yl)oxy)-5-hydroxycyclohexane-1,3-diyl)dicarbamate)

Conditions

Conditions	Yield
With triethylamine In water at 60℃; for 0.666667h;	98%
With triethylamine In methanol; water at 55℃;	98%
With triethylamine In methanol; water at 55℃;	97%

: 32986-56-4
tobramycin

: 5-benzoyl-3-(cyclopent-1-en-1-yl)-5-phenyl-1,5-dihydro-4H-pyrazol-4-one

: C25H41N5O10

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h; Solvent;	92%

: 32986-56-4
tobramycin

: 501-53-1
benzyl chloroformate

: 61093-69-4
1,3,2',6',3''-pentakis(N-benzyloxycarbonyl)-3'-deoxykanamycin B

Conditions

Conditions	Yield
With sodium carbonate	90%
With sodium carbonate In water
With sodium carbonate In acetone at 0℃;

: 32986-56-4
tobramycin

: 65162-83-6
N-(benzyloxycarbonyloxy)phthalimide

: 6'-N-benzyloxycarbonyltobramycin

Conditions

Conditions	Yield
With potassium carbonate In methanol; water at 20℃; for 18h;	64%

: azidoacetic acid succinimidyl ester

: 32986-56-4
tobramycin

: 1220984-19-9
6'-N-azidoacetyl tobramycin

Conditions

Conditions	Yield
With potassium carbonate In methanol; water for 20h;	63%

Raw Materials

23155-02-4

Total:186 Page 1 of 5 1 2 3 4 5 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 32986-56-4

Chemistry

Molecular structure of Tobramycin (CAS NO.32986-56-4) is:

Product Name: Tobramycin
CAS Registry Number: 32986-56-4
IUPAC Name: 4-amino-2-[4,6-diamino-3-[3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol
Molecular Weight: 467.51448 [g/mol]
Molecular Formula: C₁₈H₃₇N₅O₉
XLogP3-AA: -6.2
H-Bond Donor: 10
H-Bond Acceptor: 14
EINECS: 251-322-5
Refractive index: 143 ° (C=4, H₂O)
Storage temp.: 2-8°C
Solubility: H₂O: 50 mg/mL, clear, faintly yellow
Melting Point: 178 °C
Surface Tension: 92.6 dyne/cm
Density: 1.52 g/cm³
Flash Point: 422.8 °C
Enthalpy of Vaporization: 128.66 kJ/mol
Boiling Point: 775.4 °C at 760 mmHg
Vapour Pressure: 9.05E-28 mmHg at 25°C
Product Categories: Oligosaccharide Compounds; Aminoglycosides (Antibiotics for Research and Experimental Use); Antibiotics for Research and Experimental Use; Biochemistry; Intermediates & Fine Chemicals; Oligosaccharides; Pharmaceuticals; Peptide Synthesis/Antibiotics

Uses

Tobramycin (CAS NO.32986-56-4) is used to treat various types of bacterial infections, particularly Gram-negative infections. It is also combined with dexamethasone as an ophthalmic solution.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	intravenous	37714ug/kg (37.714mg/kg)	KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED	American Journal of Kidney Diseases. Vol. 23, Pg. 118, 1994.
mouse	LD50	intramuscular	440mg/kg (440mg/kg)		Yakkyoku. Pharmacy. Vol. 27, Pg. 1467, 1976.
mouse	LD50	intraperitoneal	445mg/kg (445mg/kg)		Journal of International Medical Research. Vol. 2, Pg. 100, 1974.
mouse	LD50	intravenous	72500ug/kg (72.5mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Antibiotiki. Vol. 29, Pg. 361, 1984.
mouse	LD50	oral	> 11500mg/kg (11500mg/kg)		Yakkyoku. Pharmacy. Vol. 27, Pg. 1467, 1976.
mouse	LD50	subcutaneous	367mg/kg (367mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Toxicology and Applied Pharmacology. Vol. 25, Pg. 398, 1973.
pig	LD50	subcutaneous	676mg/kg (676mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Toxicology and Applied Pharmacology. Vol. 25, Pg. 398, 1973.
rat	LD50	intramuscular	913mg/kg (913mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 107, 1977.
rat	LD50	intraperitoneal	1030mg/kg (1030mg/kg)		Journal of International Medical Research. Vol. 2, Pg. 100, 1974.
rat	LD50	intravenous	104mg/kg (104mg/kg)		Journal of International Medical Research. Vol. 2, Pg. 100, 1974.
rat	LD50	oral	> 7500mg/kg (7500mg/kg)		Yakkyoku. Pharmacy. Vol. 27, Pg. 1467, 1976.
rat	LD50	subcutaneous	969mg/kg (969mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION	Toxicology and Applied Pharmacology. Vol. 22, Pg. 332, 1972.

Consensus Reports

EPA Genetic Toxicology Program.

Safety Profile

Safty information about Tobramycin (CAS NO.32986-56-4) is:
Poison by intravenous and subcutaneous routes. Moderately toxic by intramuscular and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 2
RTECS: WK2100000
F: 3-10

Specification

Tobramycin , its cas register number is 32986-56-4. It also can be called Tobramycin [USAN:INN:BAN:JAN] ; Tobradex ; Tobrasone ; 1-Epitobramycin ; 3'-Deoxykanamycin B ; 4-(2,6-Diamino-2,3,6-trideoxy-alpha-D-glycopyranosyl)-6-(3-amino-3-deoxy-alpha-D-glycopyranosyl)-2-deoxystreptamine ; Aktob ; D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1-4))-2-deoxy- ; Deoxykanamycin B ; Gotabiotic ; Nebramycin ; O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1-6))-2-deoxy-L-streptamine ; O-3-Amino-3-deoxy-alpha-D-lucopyranosyl-(1-6)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ibohexopyranosyl-(1-4))-2-deoxy-D-streptamine ; Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-tyrideoxy-alpha-D-ribohexopyranosyl-(1-6))-2-deoxy-, D- ; Tenebrimycin ; Tenemycin ; Tobacin ; Tobi ; Tobracin ; Tobradistin ; Tobralex ; Tobramaxin ; Tobramicin ; Tobramicina ; Tobramitsetin ; Tobramycetin ; Tobramycine ; Tobramycinum ; Tobrased ; Tobrex ; D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1-4))-2-deoxy- ; Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-6))-2-deoxy-, D- . It is a white solid. Like other aminoglycosides, In genetically susceptible individuals, it can cause deafness or a loss of equilibrioception (vertigo) .It can also be highly toxic to the kidneys, particularly if multiple doses accumulate over a course of treatment. For these reasons, when it is given parenterally, it is usually dosed by body weight. Various formulae exist for calculating tobramycin dosage.