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33125-05-2

Basic Information
CAS No.: 33125-05-2
Name: Boc-D-Phenylglycine
Article Data: 77
Molecular Structure:
Molecular Structure of 33125-05-2 (Boc-D-Phenylglycine)
Formula: C13H17NO4
Molecular Weight: 251.282
Synonyms: Benzeneaceticacid, a-[[(1,1-dimethylethoxy)carbonyl]amino]-,(R)-;(R)-N-Boc-2-amino-2-phenylaceticacid;(R)-[(tert-Butoxycarbonyl)amino]phenylethanoicacid;BOC-D-Phg-OH;D-2-tert-Butoxycarboxamido-2-phenylacetic acid;N-(tert-Butoxycarbonyl)-D-2-phenylglycine;N-tert-Butyloxycarbonyl-D-phenylglycine;
EINECS: 1533716-785-6
Density: 1.182 g/cm3
Melting Point: 88-91 °C
Boiling Point: 407.2 °C at 760 mmHg
Flash Point: 200.1 °C
Solubility: Insoluble in water. Slightly soluble in DMSO and methanol.
Safety: 24/25
PSA: 66.84000
LogP: 2.51270
Synthetic route
24424-99-5

di-tert-butyl dicarbonate

875-74-1

(R)-phenylglycine

33125-05-2

Boc-D-Phg-OH

Conditions
ConditionsYield
With sodium hydroxide In tert-butyl alcohol at 20℃; for 1h; Inert atmosphere;100%
With potassium hydrogencarbonate In tetrahydrofuran; water for 18h;99%
With sodium hydroxide96%
875-74-1

(R)-phenylglycine

58632-95-4

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

33125-05-2

Boc-D-Phg-OH

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water for 18h;94%
875-74-1

(R)-phenylglycine

tert-butyl (2,4-dioxo-3-azaspiro[5,5]undecan-3-yl) carbonate

33125-05-2

Boc-D-Phg-OH

Conditions
ConditionsYield
With sodium carbonate In 1,4-dioxane; water at 25℃; for 12h;89%
956101-46-5

tert-butyl [(1S)-1-phenylprop-2-en-1-yl]imidocarbonate

33125-05-2

Boc-D-Phg-OH

Conditions
ConditionsYield
With ruthenium trichloride; sodium periodate In tetrachloromethane; water; acetonitrile85%
875-74-1

(R)-phenylglycine

50739-44-1

1-(t-butoxycarbonyl)-1,2,4-triazolo<4,3-a>pyridinium-3-olate

33125-05-2

Boc-D-Phg-OH

Conditions
ConditionsYield
With sodium hydroxide In acetone for 2h; Ambient temperature;84%
2900-27-8, 3601-66-9, 14675-97-9, 33125-05-2

2-(tert-butoxycarbonylamino)-2-phenylacetic acid

33125-05-2

Boc-D-Phg-OH

Conditions
ConditionsYield
82%
125414-45-1

(2R,3R)-3-<(tert-butoxycarbonyl)amino>-3-phenyl-1,2-propanediol

33125-05-2

Boc-D-Phg-OH

Conditions
ConditionsYield
With ruthenium trichloride; sodium periodate; sodium carbonate In tetrachloromethane; water; acetonitrile for 2h; Ambient temperature;79%
67341-01-9, 117049-14-6, 138457-46-2, 102089-74-7

(R)-N-(tert-butoxycarbonyl)phenylglycinol

33125-05-2

Boc-D-Phg-OH

Conditions
ConditionsYield
With ruthenium trichloride; sodium periodate In tetrachloromethane; water; acetonitrile at 0 - 20℃; for 1h;77%
With dipyridinium dichromate In N,N-dimethyl-formamide Ambient temperature;
With dipyridinium dichromate In N,N-dimethyl-formamide for 6h; Ambient temperature;

C16H17F6NO4

A

33125-05-2

Boc-D-Phg-OH

B

2900-27-8

(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

Conditions
ConditionsYield
With C28H30N3O2(1+)*Br(1-); sodium hydroxide In chloroform at 0℃; for 24h;A n/a
B 35%
124-38-9

carbon dioxide

186375-61-1

N-(triisopropylsilyl)-N-(tert-butyloxycarbonyl)benzylamine

33125-05-2

Boc-D-Phg-OH

Conditions
ConditionsYield
Stage #1: N-(triisopropylsilyl)-N-(tert-butyloxycarbonyl)benzylamine With sec.-butyllithium; (-)-sparteine In diethyl ether; cyclohexane at -78℃; for 3h;
Stage #2: carbon dioxide In diethyl ether; cyclohexane for 0.333333h;
7%
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Chemistry

The Molecular formula of  Boc-D-Phg-OH(33125-05-2): C13H17NO
The Molecular Weight of  Boc-D-Phg-OH(33125-05-2): 251.2784
The Molecular Structure of Boc-D-Phg-OH(2900-27-8):
Index of Refraction: 1.532 
Molar Refractivity: 65.86 cm3 
Molar Volume: 212.5 cm
Polarizability: 26.11 10 -24 cm
Surface Tension: 45.2 dyne/cm 
Boiling Point: 407.2 °C at 760 mmHg 
Density: 1.182 g/cm
Flash Point: 200.1 °C 
Enthalpy of Vaporization: 69.49 kJ/mol 
Vapour Pressure: 2.32E-07 mmHg at 25°C

Safety Profile

The Safety Statements information of Boc-D-Phg-OH(33125-05-2):
24/25:  Avoid contact with skin and eyes 
WGK Germany: 3