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| CAS No.: | 333-36-8 |
|---|---|
| Name: | BIS(2,2,2-TRIFLUOROETHYL) ETHER |
| Article Data: | 19 |
| Molecular Structure: | |
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|
|
| Formula: | C4H4 F6 O |
| Molecular Weight: | 182.066 |
| Synonyms: | Ether,bis(2,2,2-trifluoroethyl) (6CI,7CI,8CI);2-(2,2,2-Trifluoroethoxy)-1,1,1-trifluoroethane; Bis(2,2,2-trifluoroethyl) ether;Fluorothyl; Fluroethyl; Flurothyl; Flurotyl; HFE 356mff2; Hexafluorodiethylether; Idoklon; Indiklon; Indoklon; SKF 6539 |
| Density: | 1.361g/cm3 |
| Melting Point: | 25°C |
| Boiling Point: | 63.9°Cat760mmHg |
| Flash Point: | 1.7°C |
| Appearance: | clear colorless liquid |
| Hazard Symbols: | F,Xi,T |
| Risk Codes: | 11-36/37/38 |
| Safety: | A poison by intravenous route. Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of F−. See also ETHERS and FLUORIDES. |
| PSA: | 9.23000 |
| LogP: | 2.12760 |
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Chemistry
IUPAC Name: 1,1,1-Trifluoro-2-(2,2,2-trifluoroethoxy)ethane
Synonyms of Hexafluorodiethyl ether (CAS NO.333-36-8) : 1,1,1-Trifluoro-2-(2,2,2-trifluoroethoxy)ethane ; 1,1'-Oxybis[2,2,2-trifluoroethane] ; Bis(2,2,2-trifluoroethyl) ether ; Bis(trifluoroethyl) Ether ; Ethane, 2,2'-oxybis[1,1,1-trifluoro-
CAS NO: 333-36-8
Molecular Formula:C4H4F6O
Molecular Weight :182.06
Molecular Structure :
Index of Refraction: 1.277
Surface Tension: 13.9 dyne/cm
Density: 1.361 g/cm3
Flash Point: 1.7 °C
Enthalpy of Vaporization: 29.33 kJ/mol
Boiling Point: 63.9 °C at 760 mmHg
Vapour Pressure: 180 mmHg at 25°C
Storage Temp: Flammables area
Appearance:clear colorless liquid
Uses
Hexafluorodiethyl ether (CAS NO.333-36-8)(Hexafluorodiethyl ether, Indoklon) is a volatile liquid drug from the halogenated ether family, related to inhaled anaesthetic agents such as diethyl ether, but having the opposite effects, acting as a stimulant and convulsant. Several compounds related to the halogenated ether anesthetics have similar convulsant effects rather than producing sedation, and this has been helpful in studying the mechanism of action of these drugs.Flurothyl was previously used in psychiatric medicine for shock therapy, in a similar manner to other convulsant drugs such as pentetrazol, as an alternative to electroconvulsive therapy.This use has now been discontinued, but it is still widely used in scientific research for inducing seizures in animals.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 46mg/kg (46mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 129, Pg. 223, 1960. | |
| rat | LD50 | intraperitoneal | 1260mg/kg (1260mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 129, Pg. 223, 1960. |
Safety Profile
A poison by intravenous route. Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of F−. See also ETHERS and FLUORIDES.
Hazard Codes 
F,
Xi,
T
Risk Statements 11-36/37/38
R11: Hexafluorodiethyl ether (CAS NO.333-36-8) is highly flammable.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 16-26-36
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RIDADR UN 3271 3/PG 2
WGK Germany 3
RTECS KN3675000
Hazard Note Flammable/Toxic/Convulsant
HazardClass 3.1
PackingGroup II
Specification
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire. Flammable liquid and vapor.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Use spark-proof tools and explosion proof equipment. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Flammables-area.