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CAS No.: | 333-41-5 |
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Name: | Diazinon |
Article Data: | 69 |
Molecular Structure: | |
Formula: | C12H21N2O3PS |
Molecular Weight: | 304.35 |
Synonyms: | Dassitox;Topclip 40;Diazinon AG 500;diethoxy-(6-methyl-2-propan-2-yl-pyrimidin-4-yl)oxy-sulfanylidene-phosphorane;Sarolex;Diazol;Drawizon;O,O-Diethyl O-(2-isopropyl-4-methyl-6-pyrimidinyl) phosphorothioate;Isopropylmethylpyrimidyl diethyl thiophosphate;o, o-Dietil-o- (2-isopropil-4-metil-pirimidin-il)-monotiofosato(ITALIA N);Ektoband;Kleen-Dok;O-2-Isopropyl-4-methylpyrimidyl-O,O-diethyl phosphorothioate;Diazajet;Dimpylat;Phosphorothioic acid, O, O-diethyl O- (2-isopropyl-6-methyl-4-pyrimidinyl) ester;Topclip Blue Shield;O, O-Diethyl-O- (2-isopropyl-4-methyl-pyrimidin-6-yl)-monothiofosfaat( DUTCH);O,O-Diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) thiophosphate;Basudin 10 G;Antigal;O,O-Diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) phosphorothioate;Diazitol;Phosphorothioic acid, O,O-diethyl {O-[6-methyl-2-(1-methylethyl)-4-pyrimidinyl]} ester;O,O-Diethyl O-6-methyl-2-isopropyl-4-pyrimidinyl phosphorothioate;Phosphorothioic acid, O,O-diethyl O-[6-methyl-2- (1-methylethyl)-4-pyrimidinyl] ester;Galesan;Exodin;Cooper's Flystrike Powder;Dizictol;4-Pyrimidinol, 2-isopropyl-6-methyl-, O-ester with O,O-diethyl phosphorothioate;Bazudin;Delzinon;G-24480;Dimpylate;Knox-out;O, O-Diethyl O-(2-isopropyl-4-methyl-6-pyrimidyl) thionophosphate;Diazinone;Nedcidol;Disonex;Garden Tox;KFM Blowfly Dressing;Spectracide;Phosphorothioate, O,O-diethyl O-6- (2-isopropyl-4-methylpyrimidyl);Flytrol;Bazanon;Nucidol;Topclip Blue; |
EINECS: | 206-373-8 |
Density: | 1.168 g/cm3 |
Melting Point: | >120 °C (dec.) |
Boiling Point: | 353.9 °C at 760 mmHg |
Flash Point: | 167.9 °C |
Solubility: | slightly soluble in water |
Appearance: | light to dark brown liquid |
Hazard Symbols: | Xn, N, F |
Risk Codes: | 22-50/53-36-20/21/22-11 |
Safety: | 24/25-60-61-36-26-16 |
Transport Information: | UN 2783/2810 |
PSA: | 95.37000 |
LogP: | 4.23530 |
Product Name: Diazinon (CAS NO.333-41-5)
Molecular formula :C12H21N2O3PS
Molar mass :304.35 g/mol
Appearance :Colorless to dark brown liquid
Index of Refraction: 1.523
Molar Refractivity: 79.64 cm3
Molar Volume: 260.4 cm3
Surface Tension: 45.6 dyne/cm
Density: 1.168 g/cm3
Flash Point: 167.9 °C
Enthalpy of Vaporization: 57.53 kJ/mol
Boiling Point: 353.9 °C at 760 mmHg
Vapour Pressure: 7.07E-05 mmHg at 25°C
XLogP3-AA: 3.8
H-Bond Donor: 0
H-Bond Acceptor: 5
Structure Descriptors of Diazinon (CAS NO.333-41-5):
IUPAC Name: diethoxy-(6-methyl-2-propan-2-ylpyrimidin-4-yl)oxy-sulfanylidene-λ5-phosphane
Canonical SMILES: CCOP(=S)(OCC)OC1=NC(=NC(=C1)C)C(C)C
InChI: InChI=1S/C12H21N2O3PS/c1-6-15-18(19,16-7-2)17-11-8-10(5)13-12(14-11)9(3)4/h8-9H,6-7H2,1-5H3
InChIKey: FHIVAFMUCKRCQO-UHFFFAOYSA-N
Classification Code: Acaricide; Agricultural Chemical; Cholinergic Agents; Cholinesterase inhibitors Enzyme Inhibitors; Human Data; Insecticide; Insecticides; Mutation data; Nematocide; Neurotransmitter Agents; Pesticides; Reproductive Effect; Skin / Eye Irritant; Tumor data
In 1952 , Diazinon is a thiophosphoric acid ester developed by Ciba-Geigy, a Swiss chemical company . It is a nonsystemic organophosphate insecticide formerly used to control cockroaches, silverfish, ants, and fleas in residential, non-food buildings. Diazinon was heavily used during the 1970s and early 1980s for general-purpose gardening use and indoor pest control. A bait form was used to control scavenger wasps in the western U.S.
Among cultivators of carnivorous plants, diazinon is known as the most effective systemic insecticide, capable of eradicating severe infestations of aphids, mealybugs and other sucking parasites while leaving the plant unharmed. For cultivators unable to obtain diazinon, Malathion and Acephate have been reported as less effective substitutes.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
bird - wild | LD50 | oral | 2mg/kg (2mg/kg) | Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. | |
chicken | LD50 | oral | 8400ug/kg (8.4mg/kg) | "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976. | |
duck | LD50 | oral | 3500ug/kg (3.5mg/kg) | Down to Earth. Vol. 35, Pg. 25, 1979. | |
guinea pig | LC50 | inhalation | 5500mg/m3/4H (5500mg/m3) | Proceedings of the European Society for the Study of Drug Toxicity. Vol. 15, Pg. 239, 1974. | |
guinea pig | LD50 | oral | 250mg/kg (250mg/kg) | "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976. | |
human | TDLo | oral | 214mg/kg (214mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: MUSCLE WEAKNESS SKIN AND APPENDAGES (SKIN): SWEATING: OTHER | Clinical Toxicology. Vol. 12, Pg. 435, 1978. |
mammal (species unspecified) | LD50 | unreported | 76mg/kg (76mg/kg) | "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 338, 1971. | |
mouse | LC50 | inhalation | 1600mg/m3/4H (1600mg/m3) | Proceedings of the European Society for the Study of Drug Toxicity. Vol. 15, Pg. 239, 1974. | |
mouse | LD50 | intraperitoneal | 33mg/kg (33mg/kg) | Toxicology and Applied Pharmacology. Vol. 2, Pg. 495, 1960. | |
mouse | LD50 | intravenous | 180mg/kg (180mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00023, | |
mouse | LD50 | oral | 17mg/kg (17mg/kg) | Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. Vol. 24, Pg. 268, 1983. | |
mouse | LD50 | skin | 2750mg/kg (2750mg/kg) | Journal of Toxicology and Environmental Health. Vol. 9, Pg. 491, 1982. | |
mouse | LD50 | subcutaneous | 58mg/kg (58mg/kg) | Osaka Igaku Zasshi. Vol. 71, Pg. 6099, 1959. | |
pig | LD50 | oral | 320mg/kg (320mg/kg) | Yakkyoku. Pharmacy. Vol. 31, Pg. 459, 1980. | |
pig | LD50 | skin | 633mg/kg (633mg/kg) | Yakkyoku. Pharmacy. Vol. 31, Pg. 459, 1980. | |
pigeon | LD50 | oral | 3160ug/kg (3.16mg/kg) | ASTM Special Technical Publication. Vol. (680), Pg. 157, 1979. | |
quail | LD50 | oral | 4210ug/kg (4.21mg/kg) | ASTM Special Technical Publication. Vol. (680), Pg. 157, 1979. | |
rabbit | LD50 | oral | 143mg/kg (143mg/kg) | Yakkyoku. Pharmacy. Vol. 31, Pg. 459, 1980. | |
rabbit | LD50 | skin | 3600mg/kg (3600mg/kg) | "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A131, Pg. 1983, | |
rat | LC50 | inhalation | 3500mg/m3/4H (3500mg/m3) | Farm Chemicals Handbook. Vol. -, Pg. C101, 1991. | |
rat | LD50 | intraperitoneal | 65mg/kg (65mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 436, 1955. | |
rat | LD50 | intratracheal | 210mg/kg (210mg/kg) | JAT, Journal of Applied Toxicology. Vol. 19, Pg. 133, 1999. | |
rat | LD50 | oral | 66mg/kg (66mg/kg) | Down to Earth. Vol. 35, Pg. 25, 1979. | |
rat | LD50 | skin | 180mg/kg (180mg/kg) | Proceedings of the Annual Meeting of the New Jersey Mosquito Extermination Association. Vol. -, Pg. 155, 1957. | |
rat | LD50 | unreported | 250mg/kg (250mg/kg) | Rinsho Shinkeigaku. Clinical Neurology. Vol. 23, Pg. 101, 1983. |
Safety Information of Diazinon (CAS NO.333-41-5):
Hazard Codes: Xn;N
Risk Statements: R22;R50/53
R22:Harmful if swallowed.
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: S24/25;S60;S61
S24:Avoid contact with skin.
S25:Avoid contact with eyes.
S60:This material and its container must be disposed of as hazardous waste.
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
Diazinon , its CAS NO. is 333-41-5, the synonyms are O,O-Diethyl O-2-isopropyl-4-methyl-6-pyrimidyl thiophosphate ; O,O-Diethyl O-(6-methyl-2-(1-methylethyl)-4-pyrimidinyl) phosophorothioate .