Products Categories
CAS No.: | 33483-65-7 |
---|---|
Name: | trans-4-Methylcyclohexylamine hydrochloride |
Article Data: | 37 |
Molecular Structure: | |
Formula: | C7H15N.HCl |
Molecular Weight: | 149.664 |
Synonyms: | Cyclohexanamine,4-methyl-, hydrochloride, trans- (9CI);Cyclohexylamine, 4-methyl-,hydrochloride, trans- (8CI);trans-4-Methylcyclohexanamine hydrochloride;Cyclohexanamine,4-methyl-, hydrochloride (1:1), trans-; |
Melting Point: | 260 °C |
Boiling Point: | 195.9 °C at 760 mmHg |
Flash Point: | 72.3 °C |
Safety: | 24/25 |
PSA: | 26.02000 |
LogP: | 3.02610 |
trans-4-methylcyclohexylamine hydrochloride
trans-4-methylcyclohexylamine hydrochloride
Conditions | Yield |
---|---|
In methanol; acetone at 25 - 30℃; for 3h; |
formic acid
trans-4-methylcyclohexylamine hydrochloride
N-(4-methylcyclohexyl)formamide
Conditions | Yield |
---|---|
With sodium formate at 120 - 140℃; for 2h; |
trans-4-methylcyclohexylamine hydrochloride
trans-N,4-dimethylcyclohexylamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: HCO2Na / 2 h / 120 - 140 °C 2: LiAlH4 / diethyl ether View Scheme |
trans-4-methylcyclohexylamine hydrochloride
trans-4.N-Dimetil-N-(2.4-dinitrofenil)cicloesilammina
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: HCO2Na / 2 h / 120 - 140 °C 2: LiAlH4 / diethyl ether 3: NaOEt / ethanol / Heating View Scheme |
quinoxaline-2-carboxylic acid chloride
trans-4-methylcyclohexylamine hydrochloride
1-methylcyclohexan-4-one
A
N-(trans-4-methylcyclohexyl)-2-quinoxalinecarboxamide
Conditions | Yield |
---|---|
With pyridine; hydroxylamine In ethanol; dichloromethane; water; ethyl acetate |
2-amino-4-chloropyrimidine
trans-4-methylcyclohexylamine hydrochloride
N4-((1r,4r)-4-methylcyclohexyl)pyridine-2,4-diamine
Conditions | Yield |
---|---|
With triethylamine In butan-1-ol for 36h; Reflux; | |
With triethylamine In butan-1-ol for 36h; Reflux; Inert atmosphere; | 1770 g |
trans-4-methylcyclohexylamine hydrochloride
9-((1r,4r)-4-methylcyclohexyl)-N-(5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-amine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: triethylamine / butan-1-ol / 36 h / Reflux 2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere 3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux 4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere 5.1: hydrogenchloride / water; methanol / 20 °C 5.2: 0 °C / pH 9 View Scheme | |
Multi-step reaction with 6 steps 1.1: triethylamine / butan-1-ol / 36 h / Reflux; Inert atmosphere 2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2.16 h / 10 - 20 °C / Inert atmosphere 3.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2.25 h / -74 - 0 °C / Inert atmosphere 3.2: 0.58 h / -60 °C / Inert atmosphere 3.3: Reflux; Inert atmosphere 4.1: lithium hexamethyldisilazane / 1-methyl-pyrrolidin-2-one / 90 °C / Inert atmosphere 5.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane / 0.17 h / Inert atmosphere 5.2: 3 h / 100 °C / Inert atmosphere 6.1: hydrogenchloride; water / methanol / 20 °C / Inert atmosphere View Scheme |
trans-4-methylcyclohexylamine hydrochloride
5-iodo-N4-((1R,4R)-4-methylcyclohexyl)pyrimidine-2,4-diamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / butan-1-ol / 36 h / Reflux 2: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine / butan-1-ol / 36 h / Reflux; Inert atmosphere 2: N-iodo-succinimide / N,N-dimethyl-formamide / 2.16 h / 10 - 20 °C / Inert atmosphere View Scheme |
trans-4-methylcyclohexylamine hydrochloride
5-(3-fluoropyridin-4-yl)-N4-((1R,4R)-4-methylcyclohexyl)pyrimidine-2,4-diamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / butan-1-ol / 36 h / Reflux 2: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere 3: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: triethylamine / butan-1-ol / 36 h / Reflux; Inert atmosphere 2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2.16 h / 10 - 20 °C / Inert atmosphere 3.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2.25 h / -74 - 0 °C / Inert atmosphere 3.2: 0.58 h / -60 °C / Inert atmosphere 3.3: Reflux; Inert atmosphere View Scheme |
trans-4-methylcyclohexylamine hydrochloride
9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-amine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: triethylamine / butan-1-ol / 36 h / Reflux 2: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere 3: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux 4: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1.1: triethylamine / butan-1-ol / 36 h / Reflux; Inert atmosphere 2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2.16 h / 10 - 20 °C / Inert atmosphere 3.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2.25 h / -74 - 0 °C / Inert atmosphere 3.2: 0.58 h / -60 °C / Inert atmosphere 3.3: Reflux; Inert atmosphere 4.1: lithium hexamethyldisilazane / 1-methyl-pyrrolidin-2-one / 90 °C / Inert atmosphere View Scheme |
What can I do for you?
Get Best Price
trans-4-Methylcyclohexylamine hydrochloride is an organic compound with the formula C7H15N.HCl, and its systematic name is the same with the product name. With the CAS registry number 33483-65-7, it is also named as Cyclohexanamine,4-methyl-, hydrochloride (1:1), trans-. In addition, the molecular weight is 149.66.
Physical properties of trans-4-Methylcyclohexylamine hydrochloride are: (1)ACD/LogP: 1.887; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 1; (4)#H bond donors: 2; (5)#Freely Rotating Bonds: 1; (6)Polar Surface Area: 26.02 Å2; (7)Flash Point: 72.3 °C; (8)Enthalpy of Vaporization: 44.09 kJ/mol; (9)Boiling Point: 195.9 °C at 760 mmHg; (10)Vapour Pressure: 0.347 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: Cl.C[C@H]1CC[C@H](N)CC1
(2)Std. InChI: InChI=1S/C7H15N.ClH/c1-6-2-4-7(8)5-3-6;/h6-7H,2-5,8H2,1H3;1H/t6-,7-;
(3)Std. InChIKey: GIRKJSRZELQHDX-MEZFUOHNSA-N