CAS No.3382-63-6,4-[[(4-Fluorophenyl)imino]methyl]-phenol Suppliers

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Basic Information

Molecular Structure:
CAS No.:	3382-63-6
Name:	4-[[(4-Fluorophenyl)imino]methyl]-phenol
Article Data:	23

Formula:	C₁₃H₁₀FNO
Molecular Weight:	215.227
Synonyms:	Phenol,p-[N-(p-fluorophenyl)formimidoyl]- (8CI);4-[(4-Fluorophenylimino)methyl]phenol;Phenol,4-[[(4-fluorophenyl)imino]methyl]-;
EINECS:	636-494-5
Density:	1.13 g/cm³
Melting Point:	179.0 to 183.0 °C
Boiling Point:	370.9 °C at 760 mmHg
Flash Point:	178.1 °C
PSA:	32.59000
LogP:	3.28190

Synthetic route

: 123-08-0
4-hydroxy-benzaldehyde

: 371-40-4
4-fluoroaniline

: 3382-63-6
N-(4-hydroxybenzylidene)-4-fluorobenzenamine

Conditions

Conditions	Yield
In water at 20 - 85℃; for 5.5h; Large scale;	97.5%
In methanol at 20 - 30℃; Large scale;	90%
In isopropyl alcohol at 50℃; for 1h;	88%

: 163222-33-1
ezetemibe

A: 793673-93-5
(-)-6-(4-fluorophenyl)tetrahydro-2H-pyran-2-one

B: 3382-63-6
N-(4-hydroxybenzylidene)-4-fluorobenzenamine

Conditions

Conditions	Yield
In water; acetonitrile UV-irradiation;

: 3296-02-4
p-azidofluorobenzene

: 6554-98-9
trans-4-Hydroxystilbene

A: 331-98-6, 83306-62-1, 83306-65-4
N-benzylidene-4-fluoroaniline

B: 3382-63-6
N-(4-hydroxybenzylidene)-4-fluorobenzenamine

Conditions

Conditions	Yield
With iron(II) chloride In acetonitrile at 100℃; Sealed tube; Inert atmosphere;

...Expand

: 371-40-4
4-fluoroaniline

A: 331-98-6, 83306-62-1, 83306-65-4
N-benzylidene-4-fluoroaniline

B: 3382-63-6
N-(4-hydroxybenzylidene)-4-fluorobenzenamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 5 °C / Inert atmosphere 1.2: 10 h / 20 °C / Inert atmosphere 2.1: iron(II) chloride / acetonitrile / 100 °C / Sealed tube; Inert atmosphere View Scheme

: 4-hydroxybenzenediazonium tetrafluoroborate

: 3382-63-6
N-(4-hydroxybenzylidene)-4-fluorobenzenamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium acetate; palladium diacetate / 12 h / 20 °C / Inert atmosphere 2: iron(II) chloride / acetonitrile / 100 °C / Sealed tube; Inert atmosphere View Scheme

: 3382-63-6
N-(4-hydroxybenzylidene)-4-fluorobenzenamine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 179411-51-9
N-(4-((tert-butyldimethylsilyl)oxy)benzylidene)-4-fluoroaniline

Conditions

Conditions	Yield
Stage #1: N-(4-hydroxybenzylidene)-4-fluorobenzenamine With dmap; triethylamine In dichloromethane at 0℃; for 0.166667h; Inert atmosphere; Stage #2: tert-butyldimethylsilyl chloride In dichloromethane at 0 - 20℃; Inert atmosphere;	99%
With 1H-imidazole In N,N-dimethyl-formamide at 60℃; for 4h;	97.5%

: 3382-63-6
N-(4-hydroxybenzylidene)-4-fluorobenzenamine

: 75-36-5
acetyl chloride

: C15H12FNO2

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 5h;	98%

: 3382-63-6
N-(4-hydroxybenzylidene)-4-fluorobenzenamine

: 76-83-5
trityl chloride

: 1159183-26-2
N-(4-trityloxybenzylidene)-4-fluoroaniline

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 10 - 20℃; for 1.08333h;	97.8%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 10 - 20℃;
With N-ethyl-N,N-diisopropylamine In dichloromethane at 10 - 20℃;

: 75-77-4
chloro-trimethyl-silane

: 1076200-08-2
3-[5-(4-fluorophenyl)-1,5-dioxopentyl]-4-phenyl-2-oxazolidinone

: 3382-63-6
N-(4-hydroxybenzylidene)-4-fluorobenzenamine

: 858126-22-4
3-{2-[3-(fluorophenyl)-3-(trimethyl silyloxy)-propyl]-3-(4-fluoro phenyl amino)-3-(4-trimethyl silyloxy phenyl)-1-oxo-propyl}-4-(S)-phenyl oxazolidin-2-one

Conditions

Conditions	Yield
Stage #1: 3-[5-(4-fluorophenyl)-1,5-dioxopentyl]-4-phenyl-2-oxazolidinone With dimethylsulfide borane complex; ascorbic acid; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole In dichloromethane at -10 - 8℃; for 7.25h; Inert atmosphere; Large scale; Stage #2: With dihydrogen peroxide In methanol; dichloromethane at -5 - 20℃; for 0.5h; Inert atmosphere; Large scale; Stage #3: chloro-trimethyl-silane; N-(4-hydroxybenzylidene)-4-fluorobenzenamine Large scale; Further stages;	96.3%

Yield

Stage #1: 3-[5-(4-fluorophenyl)-1,5-dioxopentyl]-4-phenyl-2-oxazolidinone With dimethylsulfide borane complex; ascorbic acid; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole In dichloromethane at -10 - 8℃; for 7.25h; Inert atmosphere; Large scale;
Stage #2: With dihydrogen peroxide In methanol; dichloromethane at -5 - 20℃; for 0.5h; Inert atmosphere; Large scale;
Stage #3: chloro-trimethyl-silane; N-(4-hydroxybenzylidene)-4-fluorobenzenamine Large scale; Further stages;

96.3%

...Expand

: 3382-63-6
N-(4-hydroxybenzylidene)-4-fluorobenzenamine

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: C16H11Cl3FNO3

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 5℃; for 6h;	95%

Raw Materials

123-08-0

371-40-4

Downstream Products

272778-12-8

Total:161 Page 1 of 5 1 2 3 4 5 Next>>

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Chemistry

The Molecular Structure of 4-[[(4-Fluorophenyl)imino]methyl]-phenol (CAS NO.3382-63-6):

Empirical Formula: C₁₃H₁₀FNO
Molecular Weight: 215.223
IUPAC Name: 4-[(4-fluoroanilino)methylidene]cyclohexa-2,5-dien-1-one
Product Categories: Intermediate of ezetimibe
Nominal Mass: 215 Da
Average Mass: 215.223 Da
Monoisotopic Mass: 215.074642 Da
Index of Refraction: 1.558
Molar Refractivity: 61.135 cm³
Molar Volume: 189.753 cm³
Surface Tension: 38.376 dyne/cm
Density: 1.134 g/cm³
Flash Point: 178.131 °C
Enthalpy of Vaporization: 64.215 kJ/mol
Boiling Point: 370.927 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C

Uses

4-[[(4-Fluorophenyl)imino]methyl]-phenol (CAS NO.3382-63-6) is used for synthesis of ezetimibe .

Specification

4-[[(4-Fluorophenyl)imino]methyl]-phenol (CAS NO.3382-63-6) is also called as 4-(4-Hydroxybenzylidene) fluoro aniline ; 2-(4 ' -Hydrophenyl)-4-fluorobenyl imine ; Alpha-4-fluorophenylimino-p-cresol ; (E)-4-((4-fluorophenylimino)methyl)phenol ; 4-Fluoro-n-(hydroxyphenyl)methylene-benzenamine .