CAS No.3387-36-8,Disodium uridine-5'-monophosphate Suppliers

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Basic Information

Molecular Structure:
CAS No.:	3387-36-8
Name:	Disodium uridine-5'-monophosphate
Article Data:	8

Formula:	C₉H₁₁N₂Na₂O₉P
Molecular Weight:	368.148
Synonyms:	5'-Uridylicacid, disodium salt (7CI,8CI,9CI);5'-UMP disodium salt;Disodium 5'-UMP;Disodium 5'-uridylate;Disodium UMP;Disodium uridine 5'-phosphate;NSC 20257;UMP disodium salt;Uridine5'-(dihydrogen phosphate) disodium salt;Uridine 5'-monophosphate disodiumsalt;Uridylic acid disodium salt;Disodium uridine-5'-monophosphate;
EINECS:	222-211-9
Density:	1.865g/cm3
Melting Point:	208-210 °C
Solubility:	40 g/100 mL (20 °C) in water
Appearance:	Crystalline
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	22-24/25-36-26
PSA:	186.78000
LogP:	-1.85850

Synthetic route

: uridine 5'-(5-dimethylaminoisoquinolin-1-yl)methylphosphate

A: 3387-36-8
disodium uridine-5'-monophosphate

B: 75795-45-8
5-dimethylamino-1-hydroxymethylisoquinoline

Conditions

Conditions	Yield
With snake venom phosphodiesterase for 3h; enzymatic hydrolysis; var.: pH;

: uridine 5'-(5-dimethylamino-2-oxidoisoquinolin-1-yl)methylphosphate

A: 3387-36-8
disodium uridine-5'-monophosphate

B: 75795-49-2
5-dimethylamino-1-hydroxymethylisoquinolin-2-oxide

Conditions

Conditions	Yield
With sodium acetate; snake venom phosphodiesterase at 37℃; for 3h; enzymatic hydrolysis, pH=8; half-life=7 h (pH=4.1), 12 h (pH=10.1), 24 h (pH=7.1), T=37 deg C;

: 154-85-8
orotic acid sodium salt

: 87372-47-2, 94902-32-6, 108321-05-7, 129136-58-9
5-phospho-D-ribosyl α-1-pyrophosphate

: 3387-36-8
disodium uridine-5'-monophosphate

Conditions

Conditions	Yield
With DL-dithiothreitol; magnesium chloride for 192h; PAN-immobilized O-5-decarboxylase, O-5-P-pyrophosphorylase, PPiase; Yield given;

: 58-96-8
uridine

: 3387-36-8
disodium uridine-5'-monophosphate

Conditions

Conditions	Yield
Multistep reaction.;

: orotidine 5‘-monophosphate trisodium salt

: 3387-36-8
disodium uridine-5'-monophosphate

Conditions

Conditions	Yield
With ODCase from Methanobacterium thermoautotrophicum In various solvent(s) at 55℃; pH=7.5; Enzyme kinetics; Further Variations:; Temperatures;
With orotidine 5'-monophosphate decarboxylase mutant Q215A/Y217F/R235A In aq. buffer at 25℃; pH=7.1; Kinetics; Reagent/catalyst; Enzymatic reaction;

: 532-20-7, 613-83-2, 7261-25-8, 7687-39-0, 13221-22-2, 14795-83-6, 15761-67-8, 20074-49-1, 25545-03-3, 25545-04-4, 32445-75-3, 34436-17-4, 36441-93-7, 36468-53-8, 37110-85-3, 37388-49-1, 38029-69-5, 40461-77-6, 40461-89-0, 41546-19-4, 41546-20-7, 41546-21-8, 41546-26-3, 41546-29-6, 41546-30-9, 41546-31-0, 126872-16-0, 131064-98-7
D-Ribose

: 3387-36-8
disodium uridine-5'-monophosphate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Na2ATP, MgCl26H2O, PEP-K+, DTT, K2HPO4, Na2EDTA / 72 h / PAN-immobilized pyruvate kinase, adenylate kinase, PRPP synthetase, pH 7.5 2: MgCl26H2O, DTT / 192 h / PAN-immobilized O-5-decarboxylase, O-5-P-pyrophosphorylase, PPiase View Scheme

: 108321-99-9, 150713-51-2
α,β-D-ribofuranose-5-phophate disodium salt

: 3387-36-8
disodium uridine-5'-monophosphate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 70 mmol / Na2ATP, MgCl26H2O, PEP-K+, K2HPOu, Na2EDTA / 96 h / 30 °C / immobilized PRPP synthetase, pyruvate kinase, adenylate kinase, pH 7.4 2: MgCl26H2O, DTT / 192 h / PAN-immobilized O-5-decarboxylase, O-5-P-pyrophosphorylase, PPiase View Scheme

: 4578-31-8
adenosine-5'-monophosphate disodium salt

: 3387-36-8
disodium uridine-5'-monophosphate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 94 percent / Dowex 50 W-X8 (H+ form) / H2O / 0.14 h / Heating 2: 70 mmol / Na2ATP, MgCl26H2O, PEP-K+, K2HPOu, Na2EDTA / 96 h / 30 °C / immobilized PRPP synthetase, pyruvate kinase, adenylate kinase, pH 7.4 3: MgCl26H2O, DTT / 192 h / PAN-immobilized O-5-decarboxylase, O-5-P-pyrophosphorylase, PPiase View Scheme

: C9H13N3O11P2(2-)*2Na(1+)

: 3387-36-8
disodium uridine-5'-monophosphate

Conditions

Conditions	Yield
With water; zinc(II) cation pH=5.5;

: 102-82-9
tributyl-amine

: 3387-36-8
disodium uridine-5'-monophosphate

: uridine 5′-monophosphate tributylammonium salt

Conditions

Conditions	Yield
Stage #1: disodium uridine-5'-monophosphate With DOWEX IR100S resin In water Industrial scale; Stage #2: tributyl-amine In water at 15 - 25℃; pH=6.5 - 7.5; Industrial scale;	91.4%
With DOWEX IR100S resin In water at 15 - 25℃; pH=6.5 - 7.5; Industrial scale;	91.4%
With DOWEX 50WX2-200 (H)

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Specification

Uridine 5'-Monophosphate Disodium Salt Hydrate, with the CAS NO.3387-36-8, is also called Disodium [(2R,3S,4S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate; 5'-UMP disodium; CCRIS 6562; Disodium 5'-UMP; Disodium 5'-uridylate; Disodium UMP ; Disodium uridine 5'-monophosphate; Disodium uridine 5'-phosphate; EINECS 222-211-9 ; NSC 20257; Uridine 5'MP, disodium salt; Uridine-5-monophosphate disodium salt. It belongs to Biochemistry; Nucleosides, Nucleotides & Related Reagents; Nucleotides and their analogs; Nucleic acids. Uridine 5'-Monophosphate Disodium Salt Hydrate is used as flavoring agent.

Physical properties about Uridine 5'-Monophosphate Disodium Salt Hydrate are: (1)ACD/LogP: -1.583; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): -4.92; (4)ACD/LogD (pH 7.4): -5.90; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4):1.00; (9)#H bond acceptors: 11; (10)#H bond donors: 5; (11)#Freely Rotating Bonds: 6

Uses of Uridine 5'-Monophosphate Disodium Salt Hydrate: Uridine 5'-Monophosphate Disodium Salt Hydrate is used as flavoring agent: nucleotide added to the milk to increase volume to make it closer to human milk composition, increase resistance to infants and young children. And it can be used as auxiliary liver disease drug. It also used as production of intermediate nucleic acid drugs asn health food and biochemical reagents. And it for the manufacture of uridine triphosphate (UTP), poly gland urine, drugs such Furtulon.

When you are using this chemical, please be cautious about it as the following:
1. Do not breathe dust;
2. Avoid contact with skin and eyes;
3. Wear suitable protective clothing;
4. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C9H13N2O9P.2Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18);;/q;2*+1/p-2/t4-,6-,7+,8-;;/m1../s1;
(2)InChIKey=KURVIXMFFSNONZ-WAJQJQIOSA-L;
(3)Smilesc1cn(c(=O)[nH]c1=O)[C@H]2[C@H]([C@@H]([C@H](O2)COP(=O)([O-])[O-])O)O.[Na+].[Na+]

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	3394mg/kg (3394mg/kg)	LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 618, 1975.
mouse	LD50	oral	> 12gm/kg (12000mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 618, 1975.
mouse	LD50	subcutaneous	3698mg/kg (3698mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 618, 1975.
rat	LD50	intraperitoneal	3111mg/kg (3111mg/kg)	LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 618, 1975.
rat	LD50	oral	> 12gm/kg (12000mg/kg)		Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 618, 1975.
rat	LD50	subcutaneous	> 6gm/kg (6000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): "DERMATITIS, IRRITATIVE: AFTER SYSTEMIC EXPOSURE"	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 618, 1975.