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339-43-5

Basic Information
CAS No.: 339-43-5
Name: carbutamide
Molecular Structure:
Molecular Structure of 339-43-5 (carbutamide)
Formula: C11H17 N3 O3 S
Molecular Weight: 271.34
Synonyms: Sulfanilamide,N1-(butylcarbamoyl)- (6CI); Urea, 1-butyl-3-sulfanilyl- (7CI,8CI);1-Butyl-3-sulfanilylurea; Alentin; Aminophenurobutane; BZ 55; Bucarban; Bucrol;Bukarban; Burcol; Butisulfina; Carbutamid; Carbutamide; Diaboral; Emedan;Glucidoral; Glucofren; Glybutamide; Inbuton; Invenol;N-(4-Aminobenzenesulfonyl)-N'-butylurea; N-Butyl-N'-sulfanilylurea; N-Sulfanilyl-N'-butylurea;NSC 242409; NSC 246862; Nadisan; Nadizan; Norboral;N'-(4-Aminobenzenesulfonyl)-N-butylurea;N'-(4-Aminophenylsulfonyl)-N-butylurea;N'-(4-Aminophenylsulfonyl)-N-n-butylurea; N'-(Butylcarbamoyl)sulfanilamide;Oranil; Oranyl; Orasulin; U 6987
Density: 1.266g/cm3
Melting Point: 144-145°
Boiling Point: °Cat760mmHg
Flash Point: °C
Solubility: 535.2mg/L(37 oC)
Safety: A poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and SOx.
PSA: 109.67000
LogP: 3.50060
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Chemistry

IUPAC Name: 1-(4-Aminophenyl)sulfonyl-3-butylurea
The molecular formula of Carbutamide (CAS NO.339-43-5) is C11H17N3O3S.

                        
e molecular weight of Carbutamide (CAS NO.339-43-5) is 271.336.
Synonyms of Carbutamide (CAS NO.339-43-5): Benzenesulfonamide, 4-amino-N-((butylamino)carbonyl)- ; 1-Butyl-3-sulfanilylurea ; 1-[(4-aminobenzene)sulfonyl]-3-butylurea ; 4-Amino-N-((butylamino)carbonyl)benzenesulfonamide
Index of Refraction: 1.564  
EINECS: 206-424-4
Density: 1.266 g/ml

Uses

 Carbutamide (CAS NO.339-43-5) is used as hypoglycemic.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 250mg/kg (250mg/kg)   National Technical Information Service. Vol. AD691-490,
mouse LD50 intravenous 1920mg/kg (1920mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Diabetes. Vol. 6, Pg. 2, 1957.
mouse LD50 oral 2800mg/kg (2800mg/kg)   Farmakologiya i Toksikologiya Vol. 25, Pg. 93, 1962.
mouse LD50 subcutaneous 2640mg/kg (2640mg/kg)   Diabetes. Vol. 6, Pg. 2, 1957.
rat LD50 intravenous 980mg/kg (980mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Diabetes. Vol. 6, Pg. 2, 1957.
rat LD50 oral 4400mg/kg (4400mg/kg)   French Demande Patent Document. Vol. #2390165,

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

A poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and SOx.