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CAS No.: | 3430-13-5 |
---|---|
Name: | 5-Bromo-2-methylpyridine |
Article Data: | 16 |
Molecular Structure: | |
Formula: | C6H6BrN |
Molecular Weight: | 172.024 |
Synonyms: | 5-Bromo-2-methylpyridine;2-Methyl-5-bromopyridine;Pyridine, 5-bromo-2-methyl-;5-bormo-2-methylpyridine; |
EINECS: | -0 |
Density: | 1.494 g/cm3 |
Melting Point: | 32-36 °C |
Boiling Point: | 182.7 °C at 760 mmHg |
Flash Point: | 64.3 °C |
Appearance: | Light yellow cryst. |
Hazard Symbols: | Xn, Xi |
Risk Codes: | 36/37/38-20/21/22 |
Safety: | 26-36-36/37/39 |
PSA: | 12.89000 |
LogP: | 2.15250 |
5-Amino-2-methylpyridine
5-bromo-2-methylpyridine
Conditions | Yield |
---|---|
Stage #1: 5-Amino-2-methylpyridine With hydrogen bromide; bromine at -20 - -15℃; for 1.66667h; Stage #2: With sodium nitrite In water at 20℃; for 1h; Stage #3: With sodium hydroxide In water at -15 - 20℃; for 1h; | 99% |
Stage #1: 5-Amino-2-methylpyridine With hydrogen bromide; bromine In water at -20 - -15℃; for 1.66667h; Stage #2: With sodium hydroxide; sodium nitrite In water at -25 - 20℃; for 1h; Time; | 99% |
With potassium nitrite; sulfuric acid anschliessend Behandeln mit Kupfer(I)-bromid; |
5-bromo-2-methylpyridine
Conditions | Yield |
---|---|
at 180℃; under 33 Torr; | 61% |
Conditions | Yield |
---|---|
With aluminium trichloride; bromine at 100℃; for 2.5h; | 11% |
With aluminum (III) chloride; bromine |
picoline hydrochloride
5-bromo-2-methylpyridine
Conditions | Yield |
---|---|
With bromine Erhitzen des Reaktionsprodukts auf 130grad; |
Conditions | Yield |
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With aluminium trichloride; bromine at 100℃; for 0.5h; | A 14.4 g B 9.5 g |
With aluminium trichloride; bromine at 100℃; for 19h; | A n/a B 4.2 g |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaOCl; aqueous KOH 2: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid View Scheme |
ethyl 6-methylnicotinate
5-bromo-2-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: aqueous NH3 2: NaOCl; aqueous KOH 3: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid View Scheme | |
Multi-step reaction with 5 steps 1: N2H4+H2O 2: KNO2; aqueous HCl 4: aqueous KOH 5: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid View Scheme |
6-methylpyridine-3-carbohydrazide
5-bromo-2-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: KNO2; aqueous HCl 3: aqueous KOH 4: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid View Scheme |
6-methyl-nicotinoyl azide
5-bromo-2-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 2: aqueous KOH 3: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid View Scheme |
(6-methyl-[3]pyridyl)-carbamic acid ethyl ester
5-bromo-2-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aqueous KOH 2: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid View Scheme |
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Molecular Formula: C6H6BrN
Molar mass: 172.0225 g/mol
Density: 1.494 g/cm3
Flash Point: 64.3 °C
Index of Refraction: 1.553
Melting point: 32-36 °C
Appearance: Light yellow Cryst
Boiling Point: 182.7 °C at 760 mmHg
Vapour Pressure: 1.09 mmHg at 25°C
Structure of 5-Bromo-2-picoline (3430-13-5) :
Product Categories: blocks;Pyridines derivates;Bromides;Bromopyridines;Pyridine series;Halopyridines;Pyridines, Pyrimidines, Purines and Pteredines
Carcinogenicity of 5-Bromo-2-picoline (3430-13-5) hasn't been listed as a carcinogen by NTP, IARC,ACGIH, or CA Prop 65. And its toxicological properties have not been fully investigated.
Hazard Note: Irritant
Hazard Codes: Xn,Xi
Risk Statements:
20: Harmful by inhalation
21: Harmful in contact with skin
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
5-Bromo-2-picoline (3430-13-5) is a compound which can be called for 5-Bromo-2-methylpyridine ; 2-Methyl-5-bromopyridine .It's can be used for pharmaceutical intermediates. 5-Bromo-2-picoline (3430-13-5) is hazardous,so the first aid measures and others should be known .Such as: When on the skin: first,should flush skin with plenty of water immediatelyfor at least 15 minutes while removing contaminated clothing .Secondly,Get shoesmedical aid . Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.Then get medical aid soon.While ,it's Inhaled: Remove from exposure and move to fresh air immediately.Give artificial respiration While not breathing. when breathing is difficult, give oxygen.And as soon as to get medical aid .Then you have the ingesting of the product : Wash mouth out with water,and get medical aid immediately.
In addition, 5-Bromo-2-picoline (3430-13-5) can be stable under normal temperature and pressure conditions.It is not compatible with strong oxidizing agents and you must not take it with incompatible materials .And also prevent it to broken down into hazardous decomposition products: hydrogen bromide, oxides of nitrogen,carbon dioxide,carbon monoxide.