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34444-01-4

Basic Information
CAS No.: 34444-01-4
Name: 7-[(2-Hydroxy-2-phenylacetyl)amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Article Data: 8
Molecular Structure:
Molecular Structure of 34444-01-4 (7-[(2-Hydroxy-2-phenylacetyl)amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid)
Formula: C18H18 N6 O5 S2
Molecular Weight: 462.51
Synonyms: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[(hydroxyphenylacetyl)amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,[6R-[6a,7b(R*)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2R)-hydroxyphenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,(6R,7R)- (9CI);3-(1-Methyltetrazol-5-ylthiomethyl)-7-D-mandelamido-3-cephem-4-carboxylic acid;CMT; Cefadole; Cefamandol; Cefamandole; Cephadole; Cephamandole; L-Cefamandole
EINECS: 252-030-0
Density: 1.75 g/cm3
Boiling Point: °Cat760mmHg
Flash Point: °C
Appearance: White to off-white powder
PSA: 201.14000
LogP: 0.10320
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Chemistry

Chemistry informtion about Cephamandole (CAS NO.34444-01-4) is:
IUPAC Name: Pentyl nitrite
Synonyms: Cefamandole ; (R*)))- ; 5-Thia-1-Azabicyclo(4.2.0)Oct-2-Ene-2-Carboxylicacid,7-((Hydroxyphenylacetyl) ; Amino)-3-(((1-Methyl-1h-Tetrazol-5-Yl)Thio)Methyl)-8-Oxo-,(6r-(6-Alpha,7-Beta ; Cefadole ; Cefamandol ; Cephadole ; Cephamandole
MF: C18H18N6O5S2
MW: 462.5
EINECS: 252-030-0 
Density: 1.75 g/cm3
Following is the molecular structure of Cephamandole (CAS NO.34444-01-4) is:

Uses

 Cephamandole (CAS NO.34444-01-4) (INN, also known as cephamandole ) is a second-generation broad-spectrum cephalosporin antibiotic. The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally.It is no longer available in the United States.

Safety Profile

Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx.

Specification

The chemical structure of Cephamandole (CAS NO.34444-01-4) , like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram (Antabuse), due to inhibition of aldehyde dehydrogenase.