CAS No.346-18-9,POLYTHIAZIDE (200 MG) Suppliers

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Basic Information

Molecular Structure:
CAS No.:	346-18-9
Name:	POLYTHIAZIDE (200 MG)

Formula:	C11H13 Cl F3 N3 O4 S3
Molecular Weight:	439.888
Synonyms:	(?à)-Nephril; (?à)-Polythiazide; 2-Methyl-3-(b,b,b-trifluoroethylthiomethyl)-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide;6-Chloro-3,4-dihydro-2-methyl-3-[[2,2,2-trifluoroethyl)thio]methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; 6-Chloro-3,4-dihydro-2-methyl-7-sulfamoyl-3-(2,2,2-trifluoroethylthiomethyl)-2H-1,2,4-benzothiadiazine1,1-dioxide; Drenusil; NSC 108161; Nephril; P 2525; Polythiazide; Renese
Density:	1.598g/cm³
Melting Point:	202.5°
Boiling Point:	580.1°Cat760mmHg
Flash Point:	304.7°C
Safety:	Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of Cl⁻, SO_x, F⁻, and NO_x.
PSA:	151.63000
LogP:	4.59280

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Chemistry

Product Name: Polythiazide (CAS NO.346-18-9)

Molecular Formula: C₁₁H₁₃ClF₃N₃O₄S₃
Molecular Weight: 439.8818296g/mol
Mol File: 346-18-9.mol
Einecs: 206-468-4
Appearance: Crystals or white powder
Boiling point: 580.1 °C at 760 mmHg
Flash Point: 304.7 °C
Density: 1.598 g/cm³
Surface Tension: 48.3 dyne/cm
Enthalpy of Vaporization: 86.79 kJ/mol
Vapour Pressure: 1.88E-13 mmHg at 25°C
XLogP3-AA: 2.6
H-Bond Donor: 2
H-Bond Acceptor: 10
Structure Descriptors of Polythiazide (CAS NO.346-18-9):
IUPAC Name: 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydrobenzo[e][1,2,4]thiadiazine-7-sulfonamide
Canonical SMILES: CN1C(NC2=CC(=C(C=C2S1(=O)=O)S(=O)(=O)N)Cl)CSCC(F)(F)F
InChI: InChI=1S/C11H13ClF3N3O4S3/c1-18-10(4-23-5-11(13,14)15)17-7-2-6(12)8(24(16,19)20)3-9(7)25(18,21)22/h2-3,10,17H,4-5H2,1H3,(H2,16,19,20)
InChIKey: CYLWJCABXYDINA-UHFFFAOYSA-N

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	450mg/kg (450mg/kg)		"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 97, 1969.
mouse	LD50	intraperitoneal	> 5gm/kg (5000mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979.
mouse	LD50	oral	> 5gm/kg (5000mg/kg)		Drugs in Japan Vol. 6, Pg. 793, 1982.
rat	LD50	intraperitoneal	400mg/kg (400mg/kg)		"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 97, 1969.
rat	LD50	oral	> 10mg/kg (10mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979.
women	LDLo	oral	300ug/kg/5D-I (0.3mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA	American Journal of Medicine. Vol. 70, Pg. 1163, 1981.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of Cl⁻, SO_x, F⁻, and NO_x.

Specification

Polythiazide ,its CAS NO. is 346-18-9,the synonyms is 2-Methyl-3-(beta,beta,beta-trifluoroethylthiomethyl)-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide ; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl-3-(((2,2,2-trifluoroethyl)thio)methyl)-, 1,1-dioxide ; 6-Chloro-3,4-dihydro-2-methyl-3-(((2,2,2-trifluoroethyl)thio)methyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide ; 6-Chloro-3,4-dihydro-2-methyl-7-sulphamoyl-3-(2,2,2-trifluoroethylthiomethyl)-2H-benzo-1,2,4-thiadiazine 1,1-dioxide ; BRN 0770371 ; CCRIS 6094 ; Drenusil ; EINECS 206-468-4 ; HSDB 850 ; NSC 108161 ; Nephril ; Renese ; UNII-36780APV5N .