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Basic Information
CAS No.: 34675-84-8
Name: CETRAXATE, HYDROCHLORIDE
Molecular Structure:
Molecular Structure of 34675-84-8 (CETRAXATE, HYDROCHLORIDE)
Formula: C17H23 N O4
Molecular Weight: 305.374
Synonyms: Benzenepropanoicacid, 4-[[[4-(aminomethyl)cyclohexyl]carbonyl]oxy]-, trans-; Cetraxate;Tranexamic acid, p-(2-carboxyethyl)phenyl ester; p-(2-Carboxyethyl)phenyltrans-4-(aminomethyl)cyclohexanecarboxylate
Density: 1.182g/cm3
Melting Point: melts over a range of 200-280°
Boiling Point: 480.9°Cat760mmHg
Flash Point: 244.6°C
Safety: Poison by intravenous route. Moderately toxic by intraperitoneal and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.
PSA: 89.62000
LogP: 3.07460
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Chemistry

IUPAC Name: 3-[4-[4-(Aminomethyl)cyclohexanecarbonyl]oxyphenyl]propanoic acid
Synonyms of Cetraxate (CAS NO.34675-84-8) : Benzenepropanoic acid, 4-(((4-(aminomethyl)cyclohexyl)carbonyl)oxy)-, trans- ; Cetraxate ; Hydrocinnamic acid, p-hydroxy-, 4-(aminomethyl)cyclohexanecarboxylate, trans- ; trans-4-(((4-(Aminomethyl)cyclohexyl)carbonyl)oxy)benzenepropanoic acid
CAS NO:34675-84-8
Molecular Formula:C17H23NO4    
Molecular Weight :305.3688   
Molecular Structure :
Index of Refraction: 1.551 
Surface Tension: 49.9 dyne/cm 
Density: 1.182 g/cm3 
Flash Point: 244.6 °C 
Enthalpy of Vaporization: 78.52 kJ/mol 
Boiling Point: 480.9 °C at 760 mmHg 
Vapour Pressure: 4.67E-10 mmHg at 25°C

Uses

Cetraxate (CAS NO.34675-84-8)  is an oral gastrointestinal medication which has a cytoprotective effect.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1520mg/kg (1520mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 323, 1980.
mouse LD50 intravenous 681mg/kg (681mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 323, 1980.
mouse LD50 subcutaneous 4310mg/kg (4310mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 323, 1980.
rat LD50 intraperitoneal 716mg/kg (716mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 323, 1980.
rat LD50 intravenous 345mg/kg (345mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 323, 1980.
rat LD50 subcutaneous 1503mg/kg (1503mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 323, 1980.

Safety Profile

Poison by intravenous route. Moderately toxic by intraperitoneal and subcutaneous routes. When Cetraxate (CAS NO.34675-84-8) is heated to decomposition, it emits toxic fumes of NOx.