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| CAS No.: | 3482-37-9 |
|---|---|
| Name: | TRIMETHYLCOLCHICINIC ACID |
| Article Data: | 15 |
| Molecular Structure: | |
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|
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| Formula: | C19H21 N O5 |
| Molecular Weight: | 343.379 |
| Synonyms: | Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-, (S)-; Colchiceine,N-deacetyl- (8CI); Colchicinic acid, O,O',O''-trimethyl- (6CI,7CI);Deacetylcolchiceine; Desacetylcolchiceine; N-Deacetylcolchiceine; NSC 36796;Trimethylcolchicinic acid |
| Density: | 1.32g/cm3 |
| Melting Point: | >230°C (dec.) |
| Boiling Point: | 629°Cat760mmHg |
| Flash Point: | 334.2°C |
| Hazard Symbols: |
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| Risk Codes: | 20/21/22 |
| Safety: | Poison by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also COLCHICINE. |
| PSA: | 91.01000 |
| LogP: | 3.09150 |
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Chemistry
IUPAC Name: 7-Amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one
Molecular Formula: C19H21NO5
Molecular Weight: 343.41
Properties: yellow-green solid
EINECS: 222-464-5
Density: 1.32g/cm3
Melting Point: >230°C (dec.)
Boiling Point: 629°C at 760mmHg
Flash Point: 334.2°C
Freely Rotating Bonds: 5
Polar Surface Area: 57.23 Å2
Index of Refraction: 1.628
Molar Refractivity: 92.35 cm3
Molar Volume: 260 cm3
Polarizability: 36.61× 10-24 cm3
Surface Tension: 59 dyne/cm
Enthalpy of Vaporization: 97.82 kJ/mol
Vapour Pressure: 1.09E-16 mmHg at 25°C
Storage temperature: −20°C
The Cas Register Number of Trimethylcolchicinic acid is 3482-37-9.The chemical synonyms of Trimethylcolchicinic acid (CAS NO.3482-37-9) are Trimethylcolchicinic acid ; 7-Amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-benzo(a)heptalen-9(5h)-on ; Deacetylcholchiceine ; Desacetylcholchiceine ; N-Deacetyl-colchicein ; Trimethyl-colchicinicaci ; N-Deacetylcolchiceine ; (S)-7-Amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxybenzo[a]heptalen-9(5H)-one .Product categories of Trimethylcolchicinic acid (CAS NO.3482-37-9) are All inhibitors ; Inhibitors ; Alkaloids forensic and veterinary standards ; Chemical structure; Drugs of abuse ; Drugs and Metabolites ; Neat compounds drugs of abuse ; Others alphabetic ; TP - TZ .The molecular structure of Trimethylcolchicinic acid (CAS NO.3482-37-9) is.png)
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Uses
Trimethylcolchicinic acid (CAS NO.3482-37-9) is used as an antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization.
Toxicity Data With Reference
| 1. | oms-mus-par 200 mg/kg | CANCAR Cancer. 3 (1950),134. | ||
| 2. | spm-mus-par 200 mg/kg | CANCAR Cancer. 2 (1950),134. | ||
| 3. | ipr-mus LD50:200 mg/kg | CANCAR Cancer. 3 (1950),124. |
Safety Profile
Poison by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also COLCHICINE.
Hazard Codes: 
Xn
Risk Statements: 20/21/22
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 36
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS: GH0960000