CAS No.35354-74-6,Honokiol Suppliers,MSDS download

Products Categories

Pharmaceutical (85)
Plant Extract (59)
Others (53)
Organic Chemicals (22)
Reagent (3)
Materials (1)
Food Additives (1)
Basic Inorganic Chemicals (1)

Basic Information

Molecular Structure:
CAS No.:	35354-74-6
Name:	Honokiol
Article Data:	19
Cas Database

Formula:	C₁₈H₁₈O₂
Molecular Weight:	266.34
Synonyms:	[1,1'-Biphenyl]-2,4'-diol,3',5-di-2-propenyl- (9CI);3',5-Diallyl-2,4'-biphenyldiol;NSC 293100;Honokiol,(S);
EINECS:	609-119-8
Density:	1.107 g/cm³
Melting Point:	87.5ºC
Boiling Point:	400.1 °C at 760 mmHg
Flash Point:	184 °C
Solubility:	DMSO: 36 mg/mL
Appearance:	Dark brown to white fine powder with pleasant odor, spicy and slightly bitter taste.
Hazard Symbols:	Xi,N
Risk Codes:	41-51/53
Safety:	26-39-61
Transport Information:	UN 3077 9/PG 3
PSA:	40.46000
LogP:	4.22180

Synthetic route

: 68592-18-7
Dimethylhonokiol

: 35354-74-6
Honokiol

Conditions

Conditions	Yield
With aluminum (III) chloride at -5 - 0℃; for 0.333333h;	97%
With boron tribromide-dimethyl sulfide complex In 1,2-dichloro-ethane at 65℃; for 15h; Reagent/catalyst; Temperature; Inert atmosphere;	95%
Stage #1: Dimethylhonokiol With triethylsilane; tris(pentafluorophenyl)borate In dichloromethane at 20℃; for 0.333333h; Inert atmosphere; Schlenk technique; Stage #2: With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Schlenk technique; Stage #3: With water In tetrahydrofuran	57.8%

: 68592-19-8
3,5′-diallyl-2′-methoxy-[1,1′-biphenyl]-4-ol

: 35354-74-6
Honokiol

Conditions

Conditions	Yield
With boron trichloride - methyl sulfide complex In dichloromethane; 1,2-dichloro-ethane for 18h; Reflux;	91%
With boron tribromide In dichloromethane at 20℃; for 0.416667h; Inert atmosphere;	90%
With boron tribromide at -15 - 20℃;
With boron tribromide In dichloromethane at 20℃; for 0.416667h; Inert atmosphere;	430 mg

: 108886-93-7
5-allyl-4'-(allyloxy)-[1,1'-biphenyl]-2-ol

: 35354-74-6
Honokiol

Conditions

Conditions	Yield
With N,N-diethylaniline at 200℃; for 24h; Claisen Rearrangement; Sealed tube; Schlenk technique; Inert atmosphere;	90%
With boron trichloride In chlorobenzene at -15℃; for 1h;	80%

: 711012-14-5
5,3'-diallyl-2,4'-bis-methoxymethoxy-biphenyl

: 35354-74-6
Honokiol

Conditions

Conditions	Yield
With hydrogenchloride In methanol at 20℃; for 44h;	89%

: 3,5'-diallyl-2'-(methoxymethoxy)-[1,1'-biphenyl]-4-ol

: 35354-74-6
Honokiol

Conditions

Conditions	Yield
With methanol; chloro-trimethyl-silane at 0 - 20℃; for 6h;	85%

: 911812-86-7
2,4'-bis-O-allylbiphenyl

A: 3,3'-diallyl biphenyl-2,4'-diol

B: 35354-74-6
Honokiol

Conditions

Conditions	Yield
for 1.33333h; Claisen Rearrangement; Microwave irradiation; Heating; Sealed tube;	A 40% B 60%
at 180℃; for 1.33333h; Claisen Rearrangement; Microwave irradiation;	A 40% B 60%
at 190℃; for 12h; Claisen Rearrangement; Sealed tube;	A 55% B 40%
at 190℃; for 12h; Claisen Rearrangement; Sealed tube;	A 55% B 40%

: 1133087-04-3
5-allyl-4'-(allyloxy)-2-methoxybiphenyl

A: 35354-74-6
Honokiol

B: 1253950-18-3
5-allyl-[1,1'-biphenyl]-2,4'-diol

Conditions

Conditions	Yield
With boron trichloride - methyl sulfide complex In dichloromethane; 1,2-dichloro-ethane for 18h; Claisen rearrangement; Reflux;	A 47% B 49%

: 126654-55-5
eudeshonokiol A

A: 35354-74-6
Honokiol

B: 60132-35-6, 92857-25-5, 108006-39-9, 122674-21-9, 143004-65-3, 4666-84-6
cryptomeridiol

Conditions

Conditions	Yield
With trifluoroacetic acid In benzene

: 126654-55-5
eudeshonokiol A

A: 35354-74-6
Honokiol

B: 13902-07-3, 15051-81-7, 72173-98-9, 98683-12-6, 117066-77-0, 1209-71-8
eudesm-4-en-11-ol

Conditions

Conditions	Yield
With trifluoroacetic acid In benzene for 10h; Ambient temperature;	A 7 mg B 3 mg

: 89-55-4
5-bromosalicyclic acid

: 35354-74-6
Honokiol

Conditions

Conditions	Yield
Multi-step reaction with 9 steps 1: 100 percent / aq. H2SO4 / Heating 2: 100 percent / i-Pr2NEt / dimethylformamide / 3 h / 20 °C 3: 86 percent / PdCl2(dppf); dppf; AcOK / dioxane / 80 °C 4: 87 percent / PdCl2(dppf); dppf; K3PO4 / dioxane / 108 °C 5: 99 percent / LiAlH4 / tetrahydrofuran / 0 °C 6: 98 percent / HF; pyridine / acetonitrile / 1 h / 20 °C 7: 80 percent / N-bromosuccinimide; triphenylphosphine / CH2Cl2 8: 52 percent / CuI / tetrahydrofuran / -26 °C 9: 89 percent / aq. HCl / methanol / 44 h / 20 °C View Scheme

Yield

Multi-step reaction with 9 steps
1: 100 percent / aq. H2SO4 / Heating
2: 100 percent / i-Pr2NEt / dimethylformamide / 3 h / 20 °C
3: 86 percent / PdCl2(dppf); dppf; AcOK / dioxane / 80 °C
4: 87 percent / PdCl2(dppf); dppf; K3PO4 / dioxane / 108 °C
5: 99 percent / LiAlH4 / tetrahydrofuran / 0 °C
6: 98 percent / HF; pyridine / acetonitrile / 1 h / 20 °C
7: 80 percent / N-bromosuccinimide; triphenylphosphine / CH2Cl2
8: 52 percent / CuI / tetrahydrofuran / -26 °C
9: 89 percent / aq. HCl / methanol / 44 h / 20 °C
View Scheme

Total:181 Page 1 of 5 1 2 3 4 5 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 35354-74-6

Chemistry

Molecular Structure of Honokiol (CAS NO.35354-74-6):

Molecular Formula: C₁₈H₁₈O₂
Molecular Weight: 266.3343
IUPAC Name: 2-(4-Hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
Synonyms of Honokiol (CAS NO.35354-74-6): NSC 293100 ; 3,5'-Diallyl-4,2'-dihydroxybiphenyl
CAS NO: 35354-74-6
Classification Code: Anti-allergic agents ; Anti-anxiety agents ; Anti-arrhythmia agents ; Anti-infective agents ; Antineoplastic Agents ; Antineoplastic agents, phytogenic ; Cardiovascular Agents ; Central Nervous System Agents ; Central nervous system depressants ; Enzyme Inhibitors ; Gastrointestinal agents ; Psychotropic Drugs ; Tranquilizing Agents
Polar Surface Area: 18.46 Å²
Index of Refraction: 1.601
Molar Refractivity: 82.42 cm³
Molar Volume: 240.4 cm³
Surface Tension: 44.6 dyne/cm
Density of Honokiol (CAS NO.35354-74-6): 1.107 g/cm³
Flash Point: 184 °C
Enthalpy of Vaporization: 67.63 kJ/mol
Boiling Point: 400.1 °C at 760 mmHg
Vapour Pressure: 5.65E-07 mmHg at 25°C

History

In the late 1990s, honokiol(35354-74-6) saw a revival in western countries as a potent and highly tolerable anti-tumorigenic and neurotrophic compound.

Uses

Honokiol (CAS NO.35354-74-6) has been used in the traditional Japanese medicine Saiboku-to as an anxiolytic, antithrombotic, anti-depressant, anti-emetic, and anti-bacterial. In the late 1990s, It saw a revival in western countries as a potent and highly tolerable anti-tumorigenic and neurotrophic compound.

Production

Synthesis

Safety Profile

Hazard Codes of Honokiol (CAS NO.35354-74-6): Irritant Xi, Dangerous N
Risk Statements: 41-51/53
R41: Risk of serious damage to the eyes.
R51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 26-39-61
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S39: Wear eye / face protection.
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 3077 9/PG 3
WGK Germany: 3