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| CAS No.: | 354-32-5 |
|---|---|
| Name: | TRIFLUOROACETYL CHLORIDE |
| Article Data: | 52 |
| Molecular Structure: | |
|
|
|
| Formula: | C2Cl F3 O |
| Molecular Weight: | 132.47 |
| Synonyms: | Acetylchloride, trifluoro- (6CI,7CI,8CI,9CI);2,2,2-Trifluoroacetyl chloride;Perfluoroacetyl chloride;Trifluoroacetyl chloride; |
| EINECS: | 206-556-2 |
| Density: | 1,335 g/cm3 |
| Melting Point: | -146ºC |
| Boiling Point: | -27ºC |
| Flash Point: | 25.1°C |
| Hazard Symbols: |
 C
|
| Risk Codes: | 14-35-37 |
| Safety: | Corrosive to skin, eyes, and materials. When heated to decomposition it emits very toxic fumes of F− and Cl−. See also FLUORIDES and CHLORIDES. |
| PSA: | 17.07000 |
| LogP: | 1.31410 |
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| Conditions | Yield |
|---|---|
| 100% |
| Conditions | Yield |
|---|---|
| With 1-methyl-1H-imidazole; diethyl chlorophosphate | 94% |
| With pyridine hydrochloride; trifluoroacetic acid |
- 75-77-4
chloro-trimethyl-silane
- 72500-13-1
C6H9F3O4S
A
- 354-32-5
trifluoracetyl chloride
B
- 72500-12-0
Trimethylsilyl-1-butansulfonat
| Conditions | Yield |
|---|---|
| for 24h; Ambient temperature; | A n/a B 91% |
- 57160-01-7
1-Chlor-1,2,2,2-tetrafluorethansulfenylchlorid
A
- 354-32-5
trifluoracetyl chloride
B
- 754-13-2
trifluorothioacetyl fluoride
| Conditions | Yield |
|---|---|
| With Cu-cuttings In gas at 400℃; under 0.008 Torr; | A 1% B 89% |
- 1493-13-6
trifluorormethanesulfonic acid
- 608-74-2
hexaiodobenzene
A
- 354-32-5
trifluoracetyl chloride
B
- 115162-16-8
C6I6(2+)*2CF3O3S(1-)
C
- 115162-13-5
C6ClI5(1+)*2CF3O3S(1-)
| Conditions | Yield |
|---|---|
| With chlorine; trifluoroacetyl triflate at 25℃; for 4h; Product distribution; Mechanism; various oxidating agent; | A n/a B 88% C 7% |
| With chlorine; trifluoroacetyl triflate at 25℃; for 4h; | A n/a B 88% C 7% |
| With chlorin; trifluoroacetyl triflate at 25℃; for 4h; | A n/a B 88% C 7% |
- 93370-09-3
methanesulphonyltrifluoroacetic anhydride
- 75-36-5
acetyl chloride
A
- 354-32-5
trifluoracetyl chloride
B
- 5539-53-7
Acetyl methanesulfonate
| Conditions | Yield |
|---|---|
| at 50℃; for 1h; Yield given; | A n/a B 86.5% |
| at 50℃; for 1h; Yields of byproduct given; | A n/a B 86.5% |
| Conditions | Yield |
|---|---|
| With phosphorus pentachloride In 1,2-dichloro-ethane for 3h; | 81% |
| With benzoyl chloride at 200℃; for 3.5h; | 50% |
| With phosphorus pentachloride |
- 2925-25-9
trifluorothioacetic acid
A
- 354-32-5
trifluoracetyl chloride
B
- 132654-09-2
N-Chlorosulfuryltrifluoroacetimide
| Conditions | Yield |
|---|---|
| With isocyanate de chlorosulfonyle Ambient temperature; | A n/a B 66% |
- 667-35-6
1,2-bis(trifluoroacetyl)hydrazine
A
- 354-32-5
trifluoracetyl chloride
B
- 58911-32-3
2,5-dichloro-1,1,1,6,6,6-hexafluoro-3,4-diaza-hexa-2,4-diene
| Conditions | Yield |
|---|---|
| With N,N-dimethylaniline hydrochloride; trichlorophosphate Heating; Yield given; | A n/a B 48% |
| With N,N-dimethylaniline hydrochloride; trichlorophosphate Heating; Yields of byproduct given; | A n/a B 48% |
- 306-83-2
1,1,1-trifluoro-2,2-dichloroethane
A
- 354-32-5
trifluoracetyl chloride
B
- 76-05-1
trifluoroacetic acid
| Conditions | Yield |
|---|---|
| With oxygen; chlorine Irradiation.UV-Licht; |
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Chemistry
IUPAC Name: 2,2,2-Trifluoroacetyl chloride (354-32-5)
Synonyms: Trifluoroacetyl chloride ; Acetyl chloride, trifluoro- ; Perfluoroacetylchloride ; Trifluoro-acetylchlorid ;Trifluoroacetyl chloride cyl. with 800 ; Trifluoroacetylchloride97% ; Trifluoracetylchlorid ; Trifluoroacetic acid chloride
CAS: 354-32-5
Molecular Formula: C2ClF3O
Molecular Weight:132.47
Molecular Structure:
EINECS: 206-556-2
Product Categories: Chemical Synthesis;Compressed and Liquefied Gases;Synthetic Reagents
Mol File: 354-32-5.mol
Surface Tension: 18.3 dyne/cm
Density: 1.532 g/cm3
Melting point: -146 °C(lit.)
Enthalpy of Vaporization: 23.25 kJ/mol
Boiling Point: -27 °C(lit.)
Vapour Pressure: 3760 mmHg at 25°C
Vapor density: 4.6 (vs air)
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LC | inhalation | > 35300ppb/6H (35.3ppm) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | National Technical Information Service. Vol. OTS0536764, |
| mouse | LCLo | inhalation | 35300ppb/6H (35.3ppm) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | National Technical Information Service. Vol. OTS0536764, |
| rat | LCLo | inhalation | 35300ppb/6H (35.3ppm) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | National Technical Information Service. Vol. OTS0536764, |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Hazard Codes C .gif){kind=small}
Risk Statements 14-35-37
14: Trifluoroacetyl chloride (354-32-5) reacts violently with water
35: Trifluoroacetyl chloride (354-32-5) can causes severe burns
37: Irritating to the respiratory system
Safety Statements 26-36/37/39-45
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39: Trifluoroacetyl chloride (354-32-5) used, please wear suitable protective clothing, gloves and eye/face protection
RIDADR UN 3057 2.3
WGK Germany 2
RTECS AO7150000
F 4.5-19-21
Hazard Note Corrosive
HazardClass 2.3 .
Standards and Recommendations
DOT Classification: 2.2; Label: Nonflammable Gas, Corrosive
Specification
1.General Description: A colorless gas. Shipped as a liquid under own vapor pressure. Contact with the unconfined liquid may frostbite unprotected skin. Very toxic by inhalation and may severely irritate skin, eyes, and mucous membranes. Under prolonged exposure to fire or heat the containers may rupture violently and rocket.
2.Air & Water Reactions: Reacts avidly with water and with moisture in the air to give fumes of hydrogen chloride, a water-soluble toxic gas.
3.Reactivity Profile: Trifluoroacetyl chloride is incompatible with strong oxidizing agents, alcohols, amines, alkalis. Reacts vigorously with amines and alkalis. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
4.Health Hazard: Toxic; may be fatal if inhaled, ingested or absorbed through skin. Vapors are extremely irritating and corrosive. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control may cause pollution.
5.Fire Hazard: Some may burn but none ignite readily. Vapors from liquefied gas are initially heavier than air and spread along ground. Some of these materials may react violently with water. Cylinders exposed to fire may vent and release toxic and/or corrosive gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket.