CAS No.3544-94-3,Chloramphenicol hemisuccinate Suppliers

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Basic Information

Molecular Structure:
CAS No.:	3544-94-3
Name:	Chloramphenicol hemisuccinate
Article Data:	8

Formula:	C15H16 Cl2 N2 O8
Molecular Weight:	423.207
Synonyms:	Butanedioicacid, mono[2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] ester,[R-(R,R)]-; Succinic acid, ester with chloramphenicol (6CI); Succinic acid, a-monoester withD-threo-(-)-2,2-dichloro-N-[b-hydroxy-a-(hydroxymethyl)-p-nitrophenethyl]acetamide(8CI); Acetamide, 2,2-dichloro-N-[b-hydroxy-a-(hydroxymethyl)-p-nitrophenethyl]-,a-(hydrogen succinate),D-(-)-threo- (8CI); Chloramphenicol 3-monosuccinate; Chloramphenicol acidsuccinate; Chloramphenicol hemisuccinate; Chloramphenicol hydrogen succinate;Chloramphenicol monosuccinate; Chloramphenicol succinate; Chloromycetinsuccinate; Chronicin foam; Kemicetine succinate; Levomycetin hemisuccinate;Levomycetin succinate; Paraxin succinate
EINECS:	222-590-0
Density:	1.536g/cm³
Melting Point:	127 °C
Boiling Point:	716.3°Cat760mmHg
Flash Point:	387°C
Safety:	Moderately toxic by subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl⁻ and NO_x. See also other chloramphenicol entries.
PSA:	162.24000
LogP:	2.68820

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Chemistry

IUPAC Name: 4-[2-[(2,2-Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoic acid
Synonyms of Chloramphenicol succinate (CAS NO.3544-94-3) : (2-((Dichloroacetyl)amino)-3-hydroxy-3-(4-nitrophenyl)propyl) hydrogen (R-(R*,R*))-succinate ; Chloramphenicol acid succinate ; Chloramphenicol hydrogen succinate ; Chloramphenicol monosuccinate
CAS NO:3544-94-3
Molecular Formula:C₁₅H₁₆Cl₂N₂O₈
Molecular Weight :423.2021
Molecular Structure :
EINECS: 222-590-0
Index of Refraction: 1.589
Surface Tension: 65.7 dyne/cm
Density: 1.536 g/cm³
Flash Point: 387 °C
Enthalpy of Vaporization: 109.91 kJ/mol
Boiling Point: 716.3 °C at 760 mmHg
Vapour Pressure: 1.56E-21 mmHg at 25°C

Uses

Chloramphenicol succinate (CAS NO.3544-94-3) is used as intermediate in organic synthesis.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
guinea pig	LD50	intravenous	1gm/kg (1000mg/kg)	Farmaco, Edizione Scientifica. Vol. 9, Pg. 21, 1954.
mouse	LD50	intraperitoneal	1400mg/kg (1400mg/kg)	Farmaco, Edizione Scientifica. Vol. 9, Pg. 21, 1954.
mouse	LD50	intravenous	1500mg/kg (1500mg/kg)	Farmaco, Edizione Scientifica. Vol. 9, Pg. 21, 1954.
mouse	LD50	oral	11gm/kg (11000mg/kg)	Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 135, 1970.
mouse	LD50	subcutaneous	4200mg/kg (4200mg/kg)	Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 135, 1970.
rat	LD50	intravenous	1720mg/kg (1720mg/kg)	Therapie. Vol. 22, Pg. 1405, 1967.
rat	LD50	oral	8300mg/kg (8300mg/kg)	Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 135, 1970.
rat	LD50	subcutaneous	2400mg/kg (2400mg/kg)	Therapie. Vol. 22, Pg. 1405, 1967.

Consensus Reports

EPA Genetic Toxicology Program.

Safety Profile

Moderately toxic by subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. When Chloramphenicol succinate (CAS NO.3544-94-3) is heated to decomposition, it emits toxic fumes of Cl⁻ and NO_x. See also other chloramphenicol entries.