CAS No.3577-01-3,cefaloglycin Suppliers

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Basic Information

Molecular Structure:
CAS No.:	3577-01-3
Name:	cefaloglycin
Article Data:	4

Formula:	C18H19 N3 O6 S
Molecular Weight:	405.431
Synonyms:	5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-[(acetyloxy)methyl]-7-[(aminophenylacetyl)amino]-8-oxo-, [6R-[6a,7b(R*)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-7-[[(2R)-aminophenylacetyl]amino]-8-oxo-, (6R,7R)- (9CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-(2-amino-2-phenylacetamido)-3-(hydroxymethyl)-8-oxo-, acetate (ester), D-(8CI); 7-(2-D-a-Aminophenylacetamido)cephalosporanicacid; Cefaloglycin; Cefaloglycine; Cephaloglycin; Cephaloglycine;D-(-)-Cephaloglycin; D-Cephaloglycine; Kafocin; Kefglycin; Lilly 39435
Density:	1.52g/cm³
Melting Point:	236.5°C (rough estimate)
Boiling Point:	761.8°C at 760 mmHg
Flash Point:	414.5°C
Solubility:	10.5g/L(25 oC)
Hazard Symbols:	Xn
Risk Codes:	42/43
Safety:	Moderately toxic by subcutaneous and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SO_x and NO_x.
PSA:	164.33000
LogP:	1.01720

Synthetic route

: 7765-60-8
(6R)-3-acetoxymethyl-7t-((R)-2-tert-butoxycarbonylamino-2-phenyl-acetylamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

: 3577-01-3
cephaloglycin

Conditions

Conditions	Yield
(i) CF3CO2H, (ii) ion exchange resin - form>; Multistep reaction;

: 24461-61-8
(R)-Phenylglycine methyl ester

: 957-68-6
7-Aminocephalosporanic acid

: 3577-01-3
cephaloglycin

Conditions

Conditions	Yield
at 30℃; for 3h; Pseudomonas melanogenum KY 3987 and KY 8540; Yield given;

: 19883-41-1
D-phenylglycine methyl ester hydrochloride

: 957-68-6
7-Aminocephalosporanic acid

: 3577-01-3
cephaloglycin

Conditions

Conditions	Yield
With potassium phosphate; Pseudomonas melanogenum KY 8541 at 30℃; pH=6.5;

: 33125-05-2
Boc-D-Phg-OH

: 3577-01-3
cephaloglycin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: (i) Et3N, (ii) iBuOCOCl, (iii) /BRN= 5406532/ 2: (i) CF3CO2H, (ii) ion exchange resin - form> View Scheme

: 10416-59-8
N,O-bis-(trimethylsilyl)-acetamide

: 3577-01-3
cephaloglycin

: 7β-[D-2-(Chromone-3-carboxamido)-2-phenylacetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid

Conditions

Conditions	Yield
In dichloromethane; ethyl acetate	55%

: 3577-01-3
cephaloglycin

: 4704-60-3
cephalosporanic acid

Conditions

Conditions	Yield
	26%

triethylamine salt of cephaloglycine: triethylamine salt of cephaloglycine

: 42835-54-1
1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid

: 3577-01-3
cephaloglycin

: 543-27-1
isobutyl chloroformate

: 71-36-3
butan-1-ol

: sodium 2-ethylhexanoic acid

: 73253-21-1, 115404-31-4
(6R)-3-acetoxymethyl-8-oxo-7t-[(R)-2-(1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carbonylamino)-2-phenyl-acetylamino]-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions

Conditions	Yield
With magnesium sulfate; triethylamine In N-methyl-acetamide; diethyl ether; dichloromethane; water

...Expand

triethylamine salt of cephaloglycine: triethylamine salt of cephaloglycine

: 42835-34-7
5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid

: 3577-01-3
cephaloglycin

: 543-27-1
isobutyl chloroformate

: 71-36-3
butan-1-ol

: sodium 2-ethylhexanoic acid

: 73253-22-2
(6R)-3-acetoxymethyl-7t-[(R)-2-((Ξ)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carbonylamino)-2-phenyl-acetylamino]-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions

Conditions	Yield
With magnesium sulfate; triethylamine In N-methyl-acetamide; diethyl ether; water

...Expand

triethylamine salt of cephaloglycine: triethylamine salt of cephaloglycine

: 3577-01-3
cephaloglycin

: 73004-70-3
8-(4-formyl-1-piperazinyl)-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid

: 543-27-1
isobutyl chloroformate

: 71-36-3
butan-1-ol

: sodium 2-ethylhexanoic acid

: 73253-23-3
(6R)-3-acetoxymethyl-7t-{(R)-2-[8-(4-formyl-piperazin-1-yl)-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carbonylamino]-2-phenyl-acetylamino}-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions

Conditions	Yield
With magnesium sulfate; triethylamine In N-methyl-acetamide; diethyl ether; water

...Expand

: 60-29-7
diethyl ether

: 3577-01-3
cephaloglycin

: sodium 2-ethylhexanoic acid

: N-[6-[4-[N-Methyl-5-oxo-L-prolylamino]phenyl]-1,2-dihydro-2-oxo-nicotinyl]-7-[D-2-amino-2-phenylacetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid

Conditions

Conditions	Yield
With dimethyl sulfoxide In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; N,N-dimethyl acetamide; ethyl acetate

...Expand

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Chemistry

Chemistry informtion about Cefaloglycin (CAS NO.3577-01-3) is:
IUPAC Name: (6R,7R)-3-(acetyloxymethyl)-7-[[(2R)-2-Amino-2-Phenylacetyl]Amino]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
Synonyms: Cefaloglycin ; Cephaloglycin ; (6r,7r)-7-[(R)-2-Amino-2-Phenylacetylamino]-3-(Acetoxymethyl)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid ; Cephaloglycin(Anhydrous) ; Kafocin ; Kefglycin ; Lilly-39435
MF: C₁₈H₁₉N₃O₆S
MW: 0
EINECS: 222-696-7
Density: 1.52 g/cm³
Flash Point: 414.5 °C
Boiling Point: 761.8 °C at 760 mmHg
Vapour Pressure: 2.14E-24 mmHg at 25°C
Enthalpy of Vaporization: 116.41 kJ/mol
Following is the molecular structure of Cefaloglycin (CAS NO.3577-01-3) is:

Production

Preparation Products is Cefpimizole .

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	1030mg/kg (1030mg/kg)	kidney, ureter, and bladder: "changes in tubules (including acute renal failure, acute tubular necrosis)"	Chemotherapy Vol. 18, Pg. 22, 1970.
mouse	LD50	oral	> 10gm/kg (10000mg/kg)	liver: other changes	Chemotherapy Vol. 18, Pg. 22, 1970.
mouse	LD50	subcutaneous	3700mg/kg (3700mg/kg)	kidney, ureter, and bladder: "changes in tubules (including acute renal failure, acute tubular necrosis)"	Chemotherapy Vol. 18, Pg. 22, 1970.
rat	LD50	intraperitoneal	1300mg/kg (1300mg/kg)	kidney, ureter, and bladder: "changes in tubules (including acute renal failure, acute tubular necrosis)"	Chemotherapy Vol. 18, Pg. 22, 1970.
rat	LD50	oral	> 10gm/kg (10000mg/kg)	liver: other changes	Chemotherapy Vol. 18, Pg. 22, 1970.
rat	LD50	subcutaneous	2800mg/kg (2800mg/kg)	kidney, ureter, and bladder: "changes in tubules (including acute renal failure, acute tubular necrosis)"	Chemotherapy Vol. 18, Pg. 22, 1970.

Safety Profile

Moderately toxic by subcutaneous and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SO_x and NO_x.

Specification

Cefaloglycin (CAS NO.3577-01-3) is a first generation cephalosporin antibiotic.