Products Categories
| CAS No.: | 35853-45-3 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Name: | 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE | ||||||||
| Article Data: | 15 | ||||||||
| Molecular Structure: | |||||||||
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| Formula: | C11H4 Br F6 N | ||||||||
| Molecular Weight: | 344.054 | ||||||||
| Synonyms: | 2,8-Bis(trifluoromethyl)-4-bromoquinoline;4-Bromo-2,8-bis(trifluoromethyl)quinoline; | ||||||||
| EINECS: | 609-183-7 | ||||||||
| Density: | 1.72g/cm3 | ||||||||
| Melting Point: |
62-64 °C(lit.) |
||||||||
| Boiling Point: | 281.6°Cat760mmHg | ||||||||
| Flash Point: | 124.1°C | ||||||||
| Hazard Symbols: |
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| Risk Codes: | R36/37/38 | ||||||||
| Safety: |
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| PSA: | 12.89000 | ||||||||
| LogP: | 5.03490 | ||||||||
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- 35853-41-9
2,8-bis(trifluoromethyl)quinolin-4-ol
- 35853-45-3
(2,8-bis-trifluoromethyl)-4-bromoquinoline
| Conditions | Yield |
|---|---|
| With phosphorus(V) oxybromide | 99% |
| With phosphorus(V) oxybromide at 120℃; for 5h; Inert atmosphere; | 98% |
| With phosphorus(V) oxybromide at 140℃; Inert atmosphere; | 98% |
- 150785-70-9
2,8-bis(trifluoromethyl)quinolin-4-yl 4-methylbenzenesulfonate
- 35853-45-3
(2,8-bis-trifluoromethyl)-4-bromoquinoline
| Conditions | Yield |
|---|---|
| With phosphorus; bromine In acetic acid at 25℃; for 4h; | 80% |
- 35853-45-3
(2,8-bis-trifluoromethyl)-4-bromoquinoline
- 40320-60-3
N-benzhydryl 3-azetidinone
- 260972-91-6
3-(2,8-bis(trifluoromethyl)-4-quinolinyl)-1-diphenylmethyl-3-azetidinol
| Conditions | Yield |
|---|---|
| With n-butyllithium In water | 100% |
- 35853-45-3
(2,8-bis-trifluoromethyl)-4-bromoquinoline
- 106-45-6
para-thiocresol
- 177092-30-7
2,8-bis(trifluoromethyl)-4-quinolyl p-tolylsulphide
| Conditions | Yield |
|---|---|
| With potassium hydroxide In methanol; ethanol at 60℃; for 2h; | 95% |
- 12093-10-6
ferrocenecarboxaldehyde
- 35853-45-3
(2,8-bis-trifluoromethyl)-4-bromoquinoline
| Conditions | Yield |
|---|---|
| Stage #1: (2,8-bis-trifluoromethyl)-4-bromoquinoline With n-butyllithium In diethyl ether; hexane at -78℃; for 0.333333h; Inert atmosphere; Schlenk technique; Stage #2: ferrocenecarboxaldehyde In diethyl ether; hexane at -78℃; for 2h; Inert atmosphere; Schlenk technique; | 94% |
- 35853-45-3
(2,8-bis-trifluoromethyl)-4-bromoquinoline
- 1031928-53-6
2,8-bis(trifluoromethyl)-4-vinylquinoline
| Conditions | Yield |
|---|---|
| With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 Suzuki Coupling; | 94% |
- 35853-45-3
(2,8-bis-trifluoromethyl)-4-bromoquinoline
- 544-92-3
copper(I) cyanide
| Conditions | Yield |
|---|---|
| In N,N-dimethyl-formamide Substitution; Heating; | 93% |
- 110-85-0
piperazine
- 35853-45-3
(2,8-bis-trifluoromethyl)-4-bromoquinoline
| Conditions | Yield |
|---|---|
| With potassium carbonate; triethylamine at 135℃; for 4h; | 92% |
- 35853-45-3
(2,8-bis-trifluoromethyl)-4-bromoquinoline
- 1241848-96-3
1-acetoxy-1'-(1,3-dioxan-2-yl)ferrocene
- 1381984-20-8
1-(1,3-dioxan-2-yl)-1'-(2,8-bis(trifluoromethyl)quinolin-4-yloxy)-ferrocene
| Conditions | Yield |
|---|---|
| Stage #1: 1-acetoxy-1'-(1,3-dioxan-2-yl)ferrocene With sodium methylate In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere; Schlenk technique; Stage #2: (2,8-bis-trifluoromethyl)-4-bromoquinoline In N,N-dimethyl-formamide at 150℃; for 6h; Inert atmosphere; Schlenk technique; | 92% |
- 35853-45-3
(2,8-bis-trifluoromethyl)-4-bromoquinoline
- 124-38-9
carbon dioxide
- 35853-50-0
2,8-bis-(trifluoromethyl)-quinoline-4-carboxylic acid
| Conditions | Yield |
|---|---|
| With n-butyllithium In diethyl ether at -35℃; for 0.333333h; | 86% |
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Specification
1.Introduction of 2,8-Bis(trifluoromethyl)-4-bromoquinoline
The 2,8-Bis(trifluoromethyl)-4-bromoquinoline, with its CAS NO 35853-45-3, is a kind of yellow solid. It has synonyms of 2,8-Bis(trifluoromethyl)-4-bromoquinoline and 4-Bromo-2,8-bis(trifluoromethyl)quinoline. 2,8-Bis(trifluoromethyl)-4-bromoquinoline should be stored in shady and cool warehouse and mainly used as pharmaceutical intermediate.
2.Properties of 2,8-Bis(trifluoromethyl)-4-bromoquinoline
(1) Polar Surface Area: 12.89 Å2 (2) Index of Refraction: 1.51 (3) Molar Refractivity: 59.83 cm3
(4) Molar Volume: 199.9 cm3 (5) Polarizability: 23.72 ×10-24 cm3 (6) Surface Tension: 30.5 dyne/cm
(7) Density: 1.72 g/cm3 (8) Flash Point: 124.1 °C (9) Enthalpy of Vaporization: 49.95 kJ/mol
(10) Boiling Point: 281.6 °C at 760 mmHg (11) Vapour Pressure: 0.00603 mmHg at 25°C
3.Structure descriptors of 2,8-Bis(trifluoromethyl)-4-bromoquinoline
IUPAC Name: 4-bromo-2,8-bis(trifluoromethyl)quinoline
InChI: InChI=1S/C11H4BrF6N/c12-7-4-8(11(16,17)18)19-9-5(7)2-1-3-6(9)10(13,
14)15/h1-4H
InChIKey: DXALAFAFIXJDOS-UHFFFAOYSA-N
Canonical SMILES : C1=CC2=C(C(=C1)C(F)(F)F)N=C(C=C2Br)C(F)(F)F
4. Safety information of 2,8-Bis(trifluoromethyl)-4-bromoquinoline
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39: Wear suitable gloves and eye/face protection.
WGK Germany: 3