CAS No.361-09-1,Sodium cholate Suppliers

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Basic Information

Molecular Structure:
CAS No.:	361-09-1
Name:	Sodium cholate
Article Data:	2

Formula:	C₂₄H₃₉NaO₅
Molecular Weight:	430.56
Synonyms:	17-(1-Methyl-3-carboxypropyl)etiocholane-3;17-beta-(1-methyl-3-carboxypropyl)etiocholane-3alpha,7alpha,12alpha-triol;3,7,12-trihydroxy-,(3-alpha,5-beta,7-alpha,12-alpha)-cholan-24-oicaci;3,7,12-trihydroxy-,(3alpha,5beta,7alpha,12alpha)-cholan-24-oicaci;3,7,12-Trihydroxy-5-chloanicacid;3,7,12-trihydroxy-cholan-24-oicacid(3-alpha,5-beta,7-alpha,12-alpha);3-alpha,7-alpha,12-alpha-trihydroxycholansaeure;
EINECS:	206-643-5
Density:	0.999 at 20.09℃
Melting Point:	198oC
Boiling Point:	583.9 °C at 760 mmHg
Flash Point:	321 °C
Solubility:	150 g/L (20 °C) in water
Appearance:	white to off-white powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	24/25-36-26
PSA:	100.82000
LogP:	2.11400

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Chemistry

Molecular Formula: C₂₄H₃₉NaO₅
Molar mass: 430.55 g/mol
Flash Point: 321 °C
Boiling Point: 583.9 °C at 760 mmHg
Vapour Pressure: 4.59E-16 mmHg at 25°C
Water solubility: 150 g/L (20°C)
Appearance: white to off-white powder
Structure of Sodium cholate(361-09-1):

Synonyms: Cholic acid sodium salt; Sodium (3a,5b,7a,12a)-3,7,12-trihydroxycholan-24-oate;3,7,12-Trihydroxy-5-chloanicacid;3,7,12-trihydroxy-,(3-alpha,5-beta,7-alpha,12-alpha)-cholan-24-oicaci
Product Categories: Anionic Surfactants;Functional Materials;Steroids;Surfactants;Bile Acids;Biochemistry;Carboxylate (Surfactants)

Uses

Sodium cholate(361-09-1) has been used for prevention of gallstone generation. And known sodium cholate(361-09-1) can be used for anti-inflammatory, too.

Production

Method 1, acids' precipitation method
Cattle (or sheep, pigs) bile [95% ethanol] → [heating reflux extraction] extract [Filter] → [distillation] extract [pH3-4] → bile acids in crude
or :Chicken (geese, ducks) bile [NaOH, boiled] → saponification solution [HCl, pH2] → total bile acid
Preparation of bile acid
Crude bile acids [Sour] → [95% ethanol] → [heating] [pH8-8.5, activated carbon] → bile acid
Methods 2, ethanol extraction
Gall ointment [carbon] → dealing with gall bladder cream
Dealing with gall bladder cream [95% ethanol] → filtrate [Recovery of ethanol] → bile salt crude
Methods 3, salting method
Khan, crude bile salts [washing] → [drying, crushing] [95% ethanol extract] → [bleaching, evaporated] bile salts Boutique
Methods 4, to cholesterol as the raw material
Primary bile acid synthesis of cholesterol in a variety of enzymes, and through a series of catabolism and ultimately the formation of conjugated primary bile acid (cholic acid and chenodeoxycholic acid).

Toxicity Data With Reference

1.	orl-mus LD50:2400 mg/kg	ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the National Hygiene Sciences.(103)(1985),29.
2.	ipr-mus LD50:164 mg/kg	ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the National Hygiene Sciences.(103)(1985),29.
3.	ivn-mus LD50:200 mg/kg	AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 90 (1952),18.
4.	ivn-rbt LDLo:50 mg/kg	ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin. 52 (1926),779.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of Na₂O. See also CHOLIC ACID.
Hazard Codes: Xi

Risk Statements:
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements:
24: Avoid contact with skin
25: Avoid contact with eyes
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing

Specification

Sodium cholate(361-09-1) is hazardous,so the first aid measures and others should be known .Such as:
Skin: Get medical aid. Should flush skin with plenty of water immediatelyfor at least 15 minutes while removing contaminated clothing and shoes.
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.
Inhalation: Remove from exposure and move to fresh air immediately.Give artificial respiration While not breathing.
Ingestion: Wash mouth out with water,and get medical aid immediately.
Notes to Physician: Treat supportively and symptomatically.
Stability and Reactivity of Sodium cholate(361-09-1):
Chemical Stability: Stable.
Incompatibilities with Other Materials: Strong oxidizing agents.
Conditions to Avoid: Incompatible materials,exposure to moist air or water.
Hazardous Decomposition Products: Carbon dioxide,carbon monoxide.