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361442-00-4

Basic Information
CAS No.: 361442-00-4
Name: Boc-3-Hydroxy-1-adamantyl-D-glycine
Molecular Structure:
Molecular Structure of 361442-00-4 (Boc-3-Hydroxy-1-adamantyl-D-glycine)
Formula: C17H27NO5
Molecular Weight: 325.4
Synonyms: (alphaS)-alpha-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid;Tricyclo[3.3.1.13,7]decane-1-acetic acid, a-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxy-, (aS)-;
EINECS: 700-361-0
Density: 1.296 g/cm3
Melting Point:
Boiling Point: 497.253 °C at 760 mmHg
Flash Point: 254.53 °C
Solubility:
Appearance:
Hazard Symbols:
Risk Codes:
Safety:
Transport Information:
PSA: 95.86000
LogP: 2.68650
Synthetic route

N-tert-butoxycarbonyl-2-(3-hydroxy-1-adamantyl)-D-glycine ethyl ester

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
With water; sodium hydroxide In ethanol at 18 - 65℃; for 2h;98.1%

(αS)-α-amino-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

24424-99-5

di-tert-butyl dicarbonate

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran at 20℃; for 12h;98%
With potassium phosphate In tetrahydrofuran; sodium hydroxide at 20℃; for 2h;88%
Stage #1: (αS)-α-amino-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid; di-tert-butyl dicarbonate With sodium hydroxide for 4h; pH=10;
Stage #2: With sulfuric acid In Isopropyl acetate; water for 0.0833333 - 0.166667h; pH=2.0 - 8;
88%

N-tert-butoxycarbonyl-3-hydroxy-1-adamantaneglycine

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
With (1R,2S)-2-Amino-1,2-diphenylethanol In ethyl acetate at 20℃; for 2h; Reflux; Resolution of racemate;56%
Multi-step reaction with 2 steps
1: ethyl acetate / 17.42 h / 20 - 70 °C / Resolution of racemate
2: hydrogenchloride / ethyl acetate; water / pH 3
View Scheme
Multi-step reaction with 2 steps
1: ethanol / 0.08 h / Resolution of racemate; Reflux
2: hydrogenchloride / water; ethyl acetate / pH 2
View Scheme
361441-97-6

(alpha S)-alpha-[[(1,1-dimethylethoxy)carbonyl]amino]tricyclo[3.3.1.13,7]decane-1-acetic acid

A

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

B

681282-72-4

(S)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dihydroxyadamantan-1-yl)acetic acid

Conditions
ConditionsYield
With potassium hydroxide; potassium permanganate at 60 - 90℃; for 1.5h;A 51%
B 17%
With potassium hydroxide; potassium permanganate In water at 60 - 90℃; for 1.5h;A 51%
B 17%
361441-97-6

(alpha S)-alpha-[[(1,1-dimethylethoxy)carbonyl]amino]tricyclo[3.3.1.13,7]decane-1-acetic acid

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
With potassium permanganate; water; potassium hydroxide at 60 - 90℃; for 1.5h;51%
With potassium permanganate; potassium hydroxide at 90℃;49%
With potassium permanganate; tetrabutylammomium bromide; potassium hydroxide In water at 20 - 25℃;18.6 g
361441-95-4

(S)-2-(adamantan-1-yl)-2-(((R)-2-hydroxy-1-phenylethyl)amino)acetonitrile

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 78 percent / aq. HCl; AcOH / 18 h / 80 °C
2: H2; AcOH / Pd(OH)2/C / methanol / 18 h / 2585.74 Torr
3: 4.07 g / K2CO3 / dimethylformamide / 19 h
4: 51 percent / KMnO4; aq. KOH / 1.5 h / 60 - 90 °C
View Scheme
Multi-step reaction with 4 steps
1: hydrogenchloride; water / acetic acid / 80 °C
2: hydrogen; palladium 10% on activated carbon / acetic acid
3: triethylamine / methanol
4: potassium permanganate; potassium hydroxide / 90 °C
View Scheme
Multi-step reaction with 4 steps
1.1: hydrogenchloride; acetic acid; water / 20 - 95 °C
2.1: acetic acid; hydrogen; 10% palladium hydroxide on charcoal / methanol / 20 °C
3.1: sodium hydroxide / water / 0.25 h / 0 - 5 °C
3.2: 0 - 5 °C
4.1: potassium permanganate; potassium hydroxide; tetrabutylammomium bromide / water / 20 - 25 °C
View Scheme
Multi-step reaction with 4 steps
1: hydrogenchloride; water / acetic acid / 18 h / 80 °C
2: hydrogen; 20% palladium hydroxide-activated charcoal / methanol; acetic acid / 18 h / 2585.81 Torr
3: potassium carbonate / N,N-dimethyl-formamide / 19 h / 20 °C / Inert atmosphere
4: water; potassium permanganate; potassium hydroxide / 1.5 h / 60 - 90 °C
View Scheme

(R)-N-((S)-(adamantan-1-yl)(carboxy)methyl)-2-hydroxy-1-phenylethan-1-ammonium chloride

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2; AcOH / Pd(OH)2/C / methanol / 18 h / 2585.74 Torr
2: 4.07 g / K2CO3 / dimethylformamide / 19 h
3: 51 percent / KMnO4; aq. KOH / 1.5 h / 60 - 90 °C
View Scheme
Multi-step reaction with 3 steps
1: hydrogen; palladium 10% on activated carbon / acetic acid
2: triethylamine / methanol
3: potassium permanganate; potassium hydroxide / 90 °C
View Scheme
Multi-step reaction with 3 steps
1.1: acetic acid; hydrogen; 10% palladium hydroxide on charcoal / methanol / 20 °C
2.1: sodium hydroxide / water / 0.25 h / 0 - 5 °C
2.2: 0 - 5 °C
3.1: potassium permanganate; potassium hydroxide; tetrabutylammomium bromide / water / 20 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1: hydrogen; 20% palladium hydroxide-activated charcoal / methanol; acetic acid / 18 h / 2585.81 Torr
2: potassium carbonate / N,N-dimethyl-formamide / 19 h / 20 °C / Inert atmosphere
3: water; potassium permanganate; potassium hydroxide / 1.5 h / 60 - 90 °C
View Scheme
770-71-8

1-adamantanemethanol

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 98 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / 1 h / -78 °C
2: 65 percent / NaHSO3 / H2O; methanol / 16 h / Heating
3: 78 percent / aq. HCl; AcOH / 18 h / 80 °C
4: H2; AcOH / Pd(OH)2/C / methanol / 18 h / 2585.74 Torr
5: 4.07 g / K2CO3 / dimethylformamide / 19 h
6: 51 percent / KMnO4; aq. KOH / 1.5 h / 60 - 90 °C
View Scheme
Multi-step reaction with 6 steps
1.1: potassium bromide; sodium hydrogencarbonate / dichloromethane / 0.25 h / 0 - 5 °C
1.2: 0 - 5 °C
2.1: sodium hydrogensulfite / methanol; water / 0 - 55 °C
3.1: hydrogenchloride; acetic acid; water / 20 - 95 °C
4.1: acetic acid; hydrogen; 10% palladium hydroxide on charcoal / methanol / 20 °C
5.1: sodium hydroxide / water / 0.25 h / 0 - 5 °C
5.2: 0 - 5 °C
6.1: potassium permanganate; potassium hydroxide; tetrabutylammomium bromide / water / 20 - 25 °C
View Scheme
Multi-step reaction with 6 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere
1.2: 0.5 h / -78 °C / Inert atmosphere
2.1: sodium hydrogensulfite / methanol; water / 18 h / 0 - 20 °C / Reflux
3.1: hydrogenchloride; water / acetic acid / 18 h / 80 °C
4.1: hydrogen; 20% palladium hydroxide-activated charcoal / methanol; acetic acid / 18 h / 2585.81 Torr
5.1: potassium carbonate / N,N-dimethyl-formamide / 19 h / 20 °C / Inert atmosphere
6.1: water; potassium permanganate; potassium hydroxide / 1.5 h / 60 - 90 °C
View Scheme
Multi-step reaction with 7 steps
1.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite; sodium bromide / dichloromethane; water / 12 h / 5 - 30 °C
2.1: sodium hydrogen sulfate / water; methanol / 5 - 77 °C
3.1: sulfuric acid / 45 - 50 °C
3.2: 2 h / 20 - 35 °C
4.1: 10 wt% Pd(OH)2 on carbon; acetic acid; hydrogen / methanol / 760.05 Torr
5.1: sulfuric acid / 110 - 112 °C
6.1: sulfuric acid; nitric acid / 10 - 25 °C
7.1: sodium hydroxide / 5 h / 25 - 30 °C
View Scheme
828-51-3

1-Adamantanecarboxylic acid

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 100 percent / diethyl ether; hexane; methanol / 3 h / 20 °C
2: 96 percent / LiAlH4 / tetrahydrofuran / 1.5 h / 0 - 20 °C
3: 98 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / 1 h / -78 °C
4: 65 percent / NaHSO3 / H2O; methanol / 16 h / Heating
5: 78 percent / aq. HCl; AcOH / 18 h / 80 °C
6: H2; AcOH / Pd(OH)2/C / methanol / 18 h / 2585.74 Torr
7: 4.07 g / K2CO3 / dimethylformamide / 19 h
8: 51 percent / KMnO4; aq. KOH / 1.5 h / 60 - 90 °C
View Scheme
Multi-step reaction with 8 steps
1.1: thionyl chloride / 3 h / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
3.1: potassium bromide; sodium hydrogencarbonate / dichloromethane / 0.25 h / 0 - 5 °C
3.2: 0 - 5 °C
4.1: sodium hydrogensulfite / methanol; water / 0 - 55 °C
5.1: hydrogenchloride; acetic acid; water / 20 - 95 °C
6.1: acetic acid; hydrogen; 10% palladium hydroxide on charcoal / methanol / 20 °C
7.1: sodium hydroxide / water / 0.25 h / 0 - 5 °C
7.2: 0 - 5 °C
8.1: potassium permanganate; potassium hydroxide; tetrabutylammomium bromide / water / 20 - 25 °C
View Scheme
Multi-step reaction with 8 steps
1.1: thionyl chloride / 4 h / Reflux
2.1: sodium / Petroleum ether / 20 °C
2.2: 20 °C
2.3: 6 h / Reflux
3.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; potassium permanganate / water; tert-butyl alcohol / 3 h / 40 - 45 °C
4.1: sodium hydroxide; hydroxylamine hydrochloride / water / 2 h
5.1: sodium hydroxide; nickel aluminum / ethanol / 8 h / 50 °C
6.1: hydrogenchloride / water; tetrahydrofuran / 20 °C / pH 10
7.1: potassium permanganate; potassium hydroxide / 2 h / 90 °C
8.1: (1R,2S)-2-Amino-1,2-diphenylethanol / ethyl acetate / 2 h / 20 °C / Reflux; Resolution of racemate
View Scheme
2094-74-8

1-Adamantanecarbaldehyde

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 65 percent / NaHSO3 / H2O; methanol / 16 h / Heating
2: 78 percent / aq. HCl; AcOH / 18 h / 80 °C
3: H2; AcOH / Pd(OH)2/C / methanol / 18 h / 2585.74 Torr
4: 4.07 g / K2CO3 / dimethylformamide / 19 h
5: 51 percent / KMnO4; aq. KOH / 1.5 h / 60 - 90 °C
View Scheme
Multi-step reaction with 5 steps
1: sodium hydrogensulfite / 0 - 60 °C
2: hydrogenchloride; water / acetic acid / 80 °C
3: hydrogen; palladium 10% on activated carbon / acetic acid
4: triethylamine / methanol
5: potassium permanganate; potassium hydroxide / 90 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium hydrogensulfite / methanol; water / 0 - 55 °C
2.1: hydrogenchloride; acetic acid; water / 20 - 95 °C
3.1: acetic acid; hydrogen; 10% palladium hydroxide on charcoal / methanol / 20 °C
4.1: sodium hydroxide / water / 0.25 h / 0 - 5 °C
4.2: 0 - 5 °C
5.1: potassium permanganate; potassium hydroxide; tetrabutylammomium bromide / water / 20 - 25 °C
View Scheme
Multi-step reaction with 5 steps
1: sodium hydrogensulfite / methanol; water / 18 h / 0 - 20 °C / Reflux
2: hydrogenchloride; water / acetic acid / 18 h / 80 °C
3: hydrogen; 20% palladium hydroxide-activated charcoal / methanol; acetic acid / 18 h / 2585.81 Torr
4: potassium carbonate / N,N-dimethyl-formamide / 19 h / 20 °C / Inert atmosphere
5: water; potassium permanganate; potassium hydroxide / 1.5 h / 60 - 90 °C
View Scheme
Multi-step reaction with 6 steps
1.1: sodium hydrogen sulfate / water; methanol / 5 - 77 °C
2.1: sulfuric acid / 45 - 50 °C
2.2: 2 h / 20 - 35 °C
3.1: 10 wt% Pd(OH)2 on carbon; acetic acid; hydrogen / methanol / 760.05 Torr
4.1: sulfuric acid / 110 - 112 °C
5.1: sulfuric acid; nitric acid / 10 - 25 °C
6.1: sodium hydroxide / 5 h / 25 - 30 °C
View Scheme
711-01-3

methyl adamantane-1-carboxylate

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 96 percent / LiAlH4 / tetrahydrofuran / 1.5 h / 0 - 20 °C
2: 98 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / 1 h / -78 °C
3: 65 percent / NaHSO3 / H2O; methanol / 16 h / Heating
4: 78 percent / aq. HCl; AcOH / 18 h / 80 °C
5: H2; AcOH / Pd(OH)2/C / methanol / 18 h / 2585.74 Torr
6: 4.07 g / K2CO3 / dimethylformamide / 19 h
7: 51 percent / KMnO4; aq. KOH / 1.5 h / 60 - 90 °C
View Scheme
Multi-step reaction with 7 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2.1: potassium bromide; sodium hydrogencarbonate / dichloromethane / 0.25 h / 0 - 5 °C
2.2: 0 - 5 °C
3.1: sodium hydrogensulfite / methanol; water / 0 - 55 °C
4.1: hydrogenchloride; acetic acid; water / 20 - 95 °C
5.1: acetic acid; hydrogen; 10% palladium hydroxide on charcoal / methanol / 20 °C
6.1: sodium hydroxide / water / 0.25 h / 0 - 5 °C
6.2: 0 - 5 °C
7.1: potassium permanganate; potassium hydroxide; tetrabutylammomium bromide / water / 20 - 25 °C
View Scheme
Multi-step reaction with 7 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere
2.2: 0.5 h / -78 °C / Inert atmosphere
3.1: sodium hydrogensulfite / methanol; water / 18 h / 0 - 20 °C / Reflux
4.1: hydrogenchloride; water / acetic acid / 18 h / 80 °C
5.1: hydrogen; 20% palladium hydroxide-activated charcoal / methanol; acetic acid / 18 h / 2585.81 Torr
6.1: potassium carbonate / N,N-dimethyl-formamide / 19 h / 20 °C / Inert atmosphere
7.1: water; potassium permanganate; potassium hydroxide / 1.5 h / 60 - 90 °C
View Scheme
95853-35-3

(S)-(+)-β-amino-1-adamantaneacetic acid

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 4.07 g / K2CO3 / dimethylformamide / 19 h
2: 51 percent / KMnO4; aq. KOH / 1.5 h / 60 - 90 °C
View Scheme
Multi-step reaction with 2 steps
1: sulfuric acid; nitric acid / 10 - 25 °C
2: sodium hydroxide / 5 h / 25 - 30 °C
View Scheme

(αS)-α-[(1,1-dimethylethoxy)carbonyl]amino-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
With hydrogenchloride In water; ethyl acetate pH=3;
1334321-39-9

N-tert-butoxycarbonyl-2-(3-hydroxy-1-adamantyl)-D-glycine

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine; isobutyl chloroformate / tetrahydrofuran / 1.5 h / -8 °C
1.2: 18 h / -8 - 25 °C
2.1: ethyl acetate / 17.42 h / 20 - 70 °C / Resolution of racemate
3.1: hydrogenchloride / ethyl acetate; water / pH 3
View Scheme
Multi-step reaction with 3 steps
1.1: dicyclohexyl-carbodiimide / dimethyl sulfoxide / 5 h / 20 °C
1.2: 53 h / 20 - 50 °C
1.3: 2 h
2.1: ethanol / 0.08 h / Resolution of racemate; Reflux
3.1: hydrogenchloride / water; ethyl acetate / pH 2
View Scheme
102502-64-7

(S)-(+)-(adamant-1-yl)aminoacetic acid hydrochloride

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / methanol
2: potassium permanganate; potassium hydroxide / 90 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 19 h / 20 °C / Inert atmosphere
2: water; potassium permanganate; potassium hydroxide / 1.5 h / 60 - 90 °C
View Scheme
59768-71-7, 60256-21-5, 95853-35-3, 100926-41-8

2-(adamantan-1-yl)-2-aminoacetic acid

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / water; tetrahydrofuran / 20 °C / pH 10
2: potassium permanganate; potassium hydroxide / 2 h / 90 °C
3: (1R,2S)-2-Amino-1,2-diphenylethanol / ethyl acetate / 2 h / 20 °C / Reflux; Resolution of racemate
View Scheme
1660-04-4

1-acetyladamantane

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; potassium permanganate / water; tert-butyl alcohol / 3 h / 40 - 45 °C
2: sodium hydroxide; hydroxylamine hydrochloride / water / 2 h
3: sodium hydroxide; nickel aluminum / ethanol / 8 h / 50 °C
4: hydrogenchloride / water; tetrahydrofuran / 20 °C / pH 10
5: potassium permanganate; potassium hydroxide / 2 h / 90 °C
6: (1R,2S)-2-Amino-1,2-diphenylethanol / ethyl acetate / 2 h / 20 °C / Reflux; Resolution of racemate
View Scheme
16091-98-8

oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium hydroxide; hydroxylamine hydrochloride / water / 2 h
2: sodium hydroxide; nickel aluminum / ethanol / 8 h / 50 °C
3: hydrogenchloride / water; tetrahydrofuran / 20 °C / pH 10
4: potassium permanganate; potassium hydroxide / 2 h / 90 °C
5: (1R,2S)-2-Amino-1,2-diphenylethanol / ethyl acetate / 2 h / 20 °C / Reflux; Resolution of racemate
View Scheme
16091-97-7

1-adamantyl-2-hydroxyiminoacetic acid

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydroxide; nickel aluminum / ethanol / 8 h / 50 °C
2: hydrogenchloride / water; tetrahydrofuran / 20 °C / pH 10
3: potassium permanganate; potassium hydroxide / 2 h / 90 °C
4: (1R,2S)-2-Amino-1,2-diphenylethanol / ethyl acetate / 2 h / 20 °C / Reflux; Resolution of racemate
View Scheme
2094-72-6

1-Adamantanecarbonyl chloride

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium / Petroleum ether / 20 °C
1.2: 20 °C
1.3: 6 h / Reflux
2.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; potassium permanganate / water; tert-butyl alcohol / 3 h / 40 - 45 °C
3.1: sodium hydroxide; hydroxylamine hydrochloride / water / 2 h
4.1: sodium hydroxide; nickel aluminum / ethanol / 8 h / 50 °C
5.1: hydrogenchloride / water; tetrahydrofuran / 20 °C / pH 10
6.1: potassium permanganate; potassium hydroxide / 2 h / 90 °C
7.1: (1R,2S)-2-Amino-1,2-diphenylethanol / ethyl acetate / 2 h / 20 °C / Reflux; Resolution of racemate
View Scheme

3-hydroxytricyclo[3.3.1.13'7]decane-1-carbaldehyde

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydrogensulfite / water / 0.17 h / 0 - 2 °C
2.1: water / 0.17 h / 0 - 2 °C
2.2: 14.5 h / -4 - 80 °C
3.1: hydrogenchloride; water / 1 h / 24 - 80 °C
3.2: 12 h / 80 - 82 °C
4.1: acetic acid; palladium(II) hydroxide; hydrogen / methanol / 5 h / 48 - 52 °C / 2625.26 - 3000.3 Torr
5.1: potassium carbonate; water / tetrahydrofuran / 0.17 h / 3 - 10 °C
5.2: 2.08 h / 3 - 26 °C
5.3: 12 h / 40 °C
View Scheme

C11H17O5S(1-)*Na(1+)

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: water / 0.17 h / 0 - 2 °C
1.2: 14.5 h / -4 - 80 °C
2.1: hydrogenchloride; water / 1 h / 24 - 80 °C
2.2: 12 h / 80 - 82 °C
3.1: acetic acid; palladium(II) hydroxide; hydrogen / methanol / 5 h / 48 - 52 °C / 2625.26 - 3000.3 Torr
4.1: potassium carbonate; water / tetrahydrofuran / 0.17 h / 3 - 10 °C
4.2: 2.08 h / 3 - 26 °C
4.3: 12 h / 40 °C
View Scheme

(2S)-[((1S)-2-hydroxy-1-phenylethyl)amino]-(3-hydroxytricyclo[3.3.1.13'7]dec-1-yl)ethanenitrile

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride; water / 1 h / 24 - 80 °C
1.2: 12 h / 80 - 82 °C
2.1: acetic acid; palladium(II) hydroxide; hydrogen / methanol / 5 h / 48 - 52 °C / 2625.26 - 3000.3 Torr
3.1: potassium carbonate; water / tetrahydrofuran / 0.17 h / 3 - 10 °C
3.2: 2.08 h / 3 - 26 °C
3.3: 12 h / 40 °C
View Scheme

(2S)-[3-chlorotricyclo[3.3.1.13'7]dec-1-yl]-[((1S)-2-hydroxy-1-phenylethyl)amino]ethanoic acid hydrochloride

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: acetic acid; palladium(II) hydroxide; hydrogen / methanol / 5 h / 48 - 52 °C / 2625.26 - 3000.3 Torr
2.1: potassium carbonate; water / tetrahydrofuran / 0.17 h / 3 - 10 °C
2.2: 2.08 h / 3 - 26 °C
2.3: 12 h / 40 °C
View Scheme
24424-99-5

di-tert-butyl dicarbonate

(2S)-amino[3-chlorotricyclo[3.3.1.13'7]dec-1-yl]ethanoic acid hydrochloride

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Stage #1: (2S)-amino[3-chlorotricyclo[3.3.1.13'7]dec-1-yl]ethanoic acid hydrochloride With water; potassium carbonate In tetrahydrofuran at 3 - 10℃; for 0.166667h;
Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran at 3 - 26℃; for 2.08333h;
Stage #3: With water at 40℃; for 12h;
1.16 g
42711-75-1

3-hydroxyadamantane-1-carboxylic acid

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium tetrahydroborate / tetrahydrofuran / 2.5 h / 0 - 31 °C
1.2: 14.5 h / 0 - 30 °C
1.3: 1 h / 0 - 10 °C
2.1: potassium bromide; sodium hydrogencarbonate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / dichloromethane; water / 0 - 5 °C
3.1: sodium hydrogensulfite / water / 0.17 h / 0 - 2 °C
4.1: water / 0.17 h / 0 - 2 °C
4.2: 14.5 h / -4 - 80 °C
5.1: hydrogenchloride; water / 1 h / 24 - 80 °C
5.2: 12 h / 80 - 82 °C
6.1: acetic acid; palladium(II) hydroxide; hydrogen / methanol / 5 h / 48 - 52 °C / 2625.26 - 3000.3 Torr
7.1: potassium carbonate; water / tetrahydrofuran / 0.17 h / 3 - 10 °C
7.2: 2.08 h / 3 - 26 °C
7.3: 12 h / 40 °C
View Scheme
38584-37-1

1-hydroxy-3-hydroxymethyladamantane

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium bromide; sodium hydrogencarbonate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / dichloromethane; water / 0 - 5 °C
2.1: sodium hydrogensulfite / water / 0.17 h / 0 - 2 °C
3.1: water / 0.17 h / 0 - 2 °C
3.2: 14.5 h / -4 - 80 °C
4.1: hydrogenchloride; water / 1 h / 24 - 80 °C
4.2: 12 h / 80 - 82 °C
5.1: acetic acid; palladium(II) hydroxide; hydrogen / methanol / 5 h / 48 - 52 °C / 2625.26 - 3000.3 Torr
6.1: potassium carbonate; water / tetrahydrofuran / 0.17 h / 3 - 10 °C
6.2: 2.08 h / 3 - 26 °C
6.3: 12 h / 40 °C
View Scheme
143467-20-3

1-acetyl-3-chloroadamantane

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: potassium hydroxide / water / 6 h / Reflux
2: potassium hydroxide; potassium permanganate / water; tert-butyl alcohol / 4.5 h / 35 - 45 °C
3: sodium hydroxide; hydroxylamine hydrochloride / water / 2 h / 0 - 5 °C / pH 7
4: sodium hydroxide; nickel-aluminum alloy / water / 50 °C
5: hydrogenchloride / water; tetrahydrofuran / 12 h / 20 °C / pH 10
6: ethanol / 0.08 h / Resolution of racemate; Reflux
7: hydrogenchloride / water; ethyl acetate / pH 2
View Scheme

C12H18NO3(1-)*Na(1+)

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / water; tetrahydrofuran / 12 h / 20 °C / pH 10
2: ethanol / 0.08 h / Resolution of racemate; Reflux
3: hydrogenchloride / water; ethyl acetate / pH 2
View Scheme

C17H27NO5*C20H24N2O2

361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
With hydrogenchloride In water; ethyl acetate pH=2;0.96 g
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

709031-45-8

(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide methane sulphonic acid

361442-01-5

tert-butyl [(1S)-2-[(1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hex-2-yl]-1-(3-hydroxytricyclo[3.3.1.13'7]dec-1-yl)-2-oxoethyl]carbamate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In ethyl acetate; acetonitrile Solvent; Large scale;98.1%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In ethyl acetate; acetonitrile for 3h;46%
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

841302-41-8

cis-2-azabicyclo[3.1.0]hexane hydrochloride

841302-42-9

(2S,3R)-1-[(2S)-N-Boc-2-(3-hydroxyadamant-1-yl)glycin]-2,3-methanopyrrolidine

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate In dichloromethane at 20℃; for 20h;97.5%
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

59483-84-0

bis(pentafluorophenyl)carbonate

pentafluorophenyl (2S)-2-((t-butoxycarbonyl)amino)-2-(3-hydroxyadamantan-1-yl)acetate

Conditions
ConditionsYield
Stage #1: (αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid With triethylamine In ethyl acetate at 25℃; for 0.666667h;
Stage #2: bis(pentafluorophenyl)carbonate In ethyl acetate at 25℃; for 2h;
93.1%
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

1312338-82-1

D-cis-4,5-methanoprolineamide methanesulfonic acid salt

1564266-87-0

(S)-N-Boc-3-hydroxyadamantylglycine-D-cis-4,5-methanoprolinamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In ethyl acetate; acetonitrile for 3h;93%
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

1659-31-0

2,2'-dipyridyl carbonate

2-pyridyl (2S)-2-((t-butoxycarbonyl)amino)-2-(3-hydroxyadamantan-1-yl)acetate

Conditions
ConditionsYield
Stage #1: (αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid With triethylamine In ethyl acetate at 25℃; for 0.666667h;
Stage #2: 2,2'-dipyridyl carbonate In ethyl acetate at 25℃; for 3h;
92.2%
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

865999-64-0

(1S)-α-amino-3-hydroxyadamantane-acetic acid hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In dichloromethane; isopropyl alcohol at 10 - 35℃; for 8h;90%
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

5070-13-3

bis-(p-nitrophenyl) carbonate

4-nitrophenyl (2S)-2-((t-butoxycarbonyl)amino)-2-(3-hydroxyadamantan-1-yl)acetate

Conditions
ConditionsYield
Stage #1: (αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid With dmap; triethylamine In N,N-dimethyl-formamide at 25℃; for 0.666667h;
Stage #2: bis-(p-nitrophenyl) carbonate In N,N-dimethyl-formamide at 70℃; for 5h; Solvent;
90%
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

(S)-N-boc-(3-hydroxyadamantan-1-yl)glycine succinimide ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 25℃; for 1h;90%
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide

361442-01-5

tert-butyl [(1S)-2-[(1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hex-2-yl]-1-(3-hydroxytricyclo[3.3.1.13'7]dec-1-yl)-2-oxoethyl]carbamate

Conditions
ConditionsYield
Stage #1: (αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid; (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide With N-ethyl-N,N-diisopropylamine In ethyl acetate at 0℃; for 0.5h;
Stage #2: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In ethyl acetate at 0 - 20℃; for 4.5h;
89.3%
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

(2S,4S,5S)-4,5-methano-L-proline carboxylamide trifluoroacetate

361442-01-5

tert-butyl [(1S)-2-[(1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hex-2-yl]-1-(3-hydroxytricyclo[3.3.1.13'7]dec-1-yl)-2-oxoethyl]carbamate

Conditions
ConditionsYield
With TEA; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;85%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 0 - 20℃;85%
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

280-57-9

1,4-diaza-bicyclo[2.2.2]octane

709031-42-5

(<αS)-<α[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxytricyclo[3.3.1.137] decane-1-acetic acid DABCO salt

Conditions
ConditionsYield
In Isopropyl acetate; water; ethyl acetate at 20℃;79%
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

1564266-70-1

L-trans-4,5-methanoprolineamide methanesulfonic acid salt

(S)-N-Boc-3-hydroxyadamantylglycine-L-trans-4,5-methanoprolinamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In ethyl acetate; acetonitrile for 3h;79%
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

1564266-74-5

D-trans-4,5-methanoprolineamide methanesulfonic acid salt

1564267-02-2

(S)-N-Boc-3-hydroxyadamantylglycine-D-trans-4,5-methanoprolinamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In ethyl acetate; acetonitrile for 3h;71%
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

841302-37-2

(1RS,5SR)-2-azabicyclo[3.1.0]hexane hydrochloride

A

841302-55-4

(2R,3S)-1-[(2S)-N-Boc-2-(3-hydroxyadamant-1-yl)glycin]-2,3-methanopyrrolidine

B

841302-42-9

(2S,3R)-1-[(2S)-N-Boc-2-(3-hydroxyadamant-1-yl)glycin]-2,3-methanopyrrolidine

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate In dichloromethane at 20℃; for 20h;A 27.4%
B 40.6%
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

681282-72-4

(S)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dihydroxyadamantan-1-yl)acetic acid

Conditions
ConditionsYield
With potassium permanganate; potassium hydroxide In water at 60 - 85℃; for 1.5h;25%
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

24426-40-2

N-(cyanomethyl)ethylamine

[(cyanomethyl-ethyl-carbamoyl)-(3-hydroxy-adamantan-1-yl)-methyl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

5616-32-0

(methylamino)acetonitrile

[(cyanomethyl-methyl-carbamoyl)-(3-hydroxy-adamantan-1-yl)-methyl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

2-amino-N-cyanomethyl-2-(3-hydroxy-adamantan-1-yl)-N-methyl-acetamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: EDAC; HOAt; Et3N / CH2Cl2
2: TFA / CH2Cl2
View Scheme
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

2-amino-N-cyanomethyl-N-ethyl-2-(3-hydroxy-adamantan-1-yl)-acetamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: EDAC; HOAt; Et3N / CH2Cl2
2: TFA / CH2Cl2
View Scheme
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

[(S)-2-((1S,3S,5S)-3-Cyano-2-aza-bicyclo[3.1.0]hex-2-yl)-1-(3-fluoro-adamantan-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 85 percent / EDAC; HOBT; TEA / dimethylformamide / 20 °C
2: 94 percent / diethylaminosulfur trifluoride / CH2Cl2 / 0.25 h / -78 °C
3: 82 percent / imidazole; pyridine; POCl3 / -20 °C
View Scheme
Multi-step reaction with 3 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C
2: diethylamino-sulfur trifluoride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere
3: 1H-imidazole; pyridine; trichlorophosphate / 0.67 h / -30 °C / Inert atmosphere
View Scheme
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

709031-43-6

3-cyano-(αS)-α-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-β-oxo-(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-2-ethanecarbamic acid 1,1-dimethylethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 85 percent / EDAC; HOBT; TEA / dimethylformamide / 20 °C
2.1: pyridine; trifluoroacetic anhydride / tetrahydrofuran / 1 h
2.2: 92 percent / aq. KOH / methanol / 18 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 4-methyl-morpholine / ethyl acetate; acetic acid butyl ester / 17.5 h / 0 °C / Inert atmosphere
2.1: trifluoroacetic anhydride; pyridine / tetrahydrofuran / 1.5 h / 0 °C
2.2: 20 - 25 °C / pH > 10
View Scheme
Multi-step reaction with 2 steps
1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / ethyl acetate; acetonitrile / 3 h
2.1: trifluoroacetic anhydride; pyridine / tetrahydrofuran / 0.5 h / 0 °C
2.2: 18 h / 20 °C
View Scheme
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

361442-06-0

(S)-N-Boc-3-fluoroadamantylglycine-L-cis-4,5-methanoprolinamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / EDAC; HOBT; TEA / dimethylformamide / 20 °C
2: 94 percent / diethylaminosulfur trifluoride / CH2Cl2 / 0.25 h / -78 °C
View Scheme
Multi-step reaction with 2 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C
2: diethylamino-sulfur trifluoride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere
View Scheme
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

(S)-3-fluoroadamantylglycine-L-cis-4,5-methanoprolinenitrile TFA salt

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 85 percent / EDAC; HOBT; TEA / dimethylformamide / 20 °C
2: 94 percent / diethylaminosulfur trifluoride / CH2Cl2 / 0.25 h / -78 °C
3: 72 percent / CH2Cl2 / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C
2: diethylamino-sulfur trifluoride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere
3: 1H-imidazole; pyridine; trichlorophosphate / 0.67 h / -30 °C / Inert atmosphere
4: dichloromethane / 0.5 h / 20 °C
View Scheme
361442-00-4

(αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

361442-05-9

(S)-3-hydroxyadamantylglycine-L-cis-4,5-methanoprolinenitrile TFA salt

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 85 percent / EDAC; HOBT; TEA / dimethylformamide / 20 °C
2.1: pyridine; trifluoroacetic anhydride / tetrahydrofuran / 1 h
2.2: 92 percent / aq. KOH / methanol / 18 h / 20 °C
3.1: 95 percent / CH2Cl2 / 2.5 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: benzotriazol-1-ol / dichloromethane / 0.08 h / -5 - 0 °C
1.2: 15.5 h / -7 - 10 °C
2.1: pyridine; trifluoroacetic anhydride / tetrahydrofuran / 6.33 h / -3 - 15 °C
2.2: 7 - 15 °C / pH 10 - 10.5
3.1: dichloromethane / -5 - 2 °C
View Scheme
Multi-step reaction with 4 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / -78 - 0 °C / Inert atmosphere
3: 1H-imidazole; pyridine; trichlorophosphate / 0.75 h / -30 °C / Inert atmosphere
4: water / dichloromethane / 1.5 h / 0 °C
View Scheme
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361442-01-5
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  • Boc-3-Hydroxy-1-adamantyl-D-glycine

  • Casno:

    361442-00-4

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    Boc-3-Hydroxy-1-adamantyl-D-glycine

    Min.Order: 1 Kilogram

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  • High purity Boc-3-Hydroxy-1-adamantyl-D-glycine CAS:361442-00-4

  • Casno:

    361442-00-4

    High purity Boc-3-Hydroxy-1-adamantyl-D-glycine CAS:361442-00-4

    Min.Order: 1 Gram

    FOB Price:  USD $ 100.0-500.0/Gram

    Items Standard Result Appearance White to off-white power White powder Solubility Soluble in meth

    Hangzhou Dingyan Chem Co., LTD. is located in the beautiful tourist city of hangzhou, is a comprehensive chemical enterprice which doing import and export business by its own comp

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     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:86-571-86465881,86-571-87157530,86-571-88025800

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  • Saxagliptin intermediate  manufacturer/supplier

  • Casno:

    361442-00-4

    Saxagliptin intermediate manufacturer/supplier

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    We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

    Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd (JL Pharm) is established in 2012 at the beautiful West Lake – Hangzhou city, China. The company's main business includes R&D, Produ

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     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-571-85829053

    Address:Rm A606, Fuyi Center, jianqiao street, Jianggan Area

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  • Boc-3-Hydroxy-1-adamantyl-D-glycin 361442-00-4 CAS NO.361442-00-4

  • Casno:

    361442-00-4

    MSDS/COA Download

    Boc-3-Hydroxy-1-adamantyl-D-glycin 361442-00-4 CAS NO.361442-00-4

    Min.Order: 1 Metric Ton

    FOB Price:  USD $ 1.0-3.0/Metric Ton

    hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

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     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:86-0311-66561638

    Address:Zhang zhe, guangzong county, xingtai city, hebei province

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  • 361442-00-4  Boc-3-Hydroxy-1-adamantyl-D-glycine

  • Casno:

    361442-00-4

    361442-00-4 Boc-3-Hydroxy-1-adamantyl-D-glycine

    Min.Order: 1 Gram

    FOB Price:  USD $ 40.0-50.0/Gram

    1.good quality 1) good quality is the basic of our goal; 2) we can offer samples to be tested; 3) 98% of our products have exported to uk, usa, germany, spain, australia, middle east and many other countries. 4) Good feedback of quality from our cu

    Mulei (Wuhan) New Material Technology Co. Ltd is a scientific and technological company integrating product research and development, manufacture and trading of chemical intermedia

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    Business Type:Trading Company

    Tel:+8619831967063

    Address:Office1201#, Block C, Hanjie Headquarters International Plaza, Zhongbei Rd, Wuchang District, Wuhan

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  • (S)-N-tert-Butyloxycarbonyl-3-HydroxyadaMantylglycine

  • Casno:

    361442-00-4

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    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice Appearance:Whit

    Located in Zhengdong New District,?Zhengzhou of Henan province, Henan Allgreen Chemical Co.,Ltd is a comprehensive high-tech modern enterprises integrating professional R&D, pro

  •  Henan Allgreen Chemical Co.,Ltd

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    Business Type:Manufacturers

    Tel:+86-0371-87507775

    Address:No 260 Dongming Road,Jinshui District

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  • Casno:

    361442-00-4

    Boc-3-Hydroxy-1-adamantyl-D-glycine

    Min.Order: 10 Milligram

    FOB Price:  USD $ 0.0-0.0/Milligram

    1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

    Founded in 2011, Amadis Chemical Company Limited is an innovative manufacturer of chemical products and technical service providers. Our business includes sales, manufacture, and s

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-571-89925085

    Address:Watts Cosine.No.166.Xiangmao Road.

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  • Intermediates of Saxagliptin 361442-00-4

  • Casno:

    361442-00-4

    Intermediates of Saxagliptin 361442-00-4

    Min.Order: 50 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Sichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we have the best quality and price. Guarantee high quality, competive price and reliable service. We fully compliance with ISO900

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     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:86-838-2274206

    Address:Room 1-11-1,No.19 of North TianShan Road,Deyang,Sichuan China

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  • (S)-N-tert-Butoxycarbonyl-3-hydroxyadamantylglycine

  • Casno:

    361442-00-4

    (S)-N-tert-Butoxycarbonyl-3-hydroxyadamantylglycine

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    Chemwill Asia co.,Ltd is one of the leading manufacturer in CHINA.Our main production base is located in Xuzhou industry park. We produce a wide range of organics including Active pharmaceutical ingredients(APIs), Veterinary, Indole derivatives, Aro

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     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:021-51086038

    Address:High-Tech Industrial park,Chemical Economical Development Zone,Xuzhou, Jiangsu-Province, P.R.China

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  • Boc-3-Hydroxy-1-adamantyl-D-glycine

  • Casno:

    361442-00-4

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    FOB Price:  USD $ 1.0-1.0/Kilogram

    Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

    Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,an

  •  Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

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    Business Type:Manufacturers

    Tel:0086-317-5105699

    Address:40# Shuiyuesi Street, Cangzhou City,Hebei Province, China.

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  • Boc-3-Hydroxy-1-adamantyl-D-glycine

  • Casno:

    361442-00-4

    Boc-3-Hydroxy-1-adamantyl-D-glycine

    Min.Order: 0 Metric Ton

    FOB Price:  USD $ 0.0-0.0/Metric Ton

    1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99

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     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

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  • Saxagliptin Intermediate 361442-00-4 API Manufacturer

  • Casno:

    361442-00-4

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    Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

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  •  Hubei XinRunde Chemical Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+8615102730682

    Address:No.43, Xinandu Industrial Park, East and West Lake District, Wuhan, Hubei, China

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  • TIANFU-CHEM Boc-3-Hydroxy-1-adamantyl-D-glycine

  • Casno:

    361442-00-4

    TIANFU-CHEM Boc-3-Hydroxy-1-adamantyl-D-glycine

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0/Kilogram

    (alphaS)-alpha-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid Basic information Product Name: (alphaS)-alpha-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-hy

    Our company engages in Electronic chemicals such as OLED,Photoresist chemical,Electrolyte additive and Intermediate Pharmaceutical production; development of noble metal catalysts,

  •  Henan Tianfu Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-371-55170693/55170694

    Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China

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  • Pharmaceutical Grade CAS 361442-00-4 with competitive price

  • Casno:

    361442-00-4

    Pharmaceutical Grade CAS 361442-00-4 with competitive price

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 139.0-210.0/Kilogram

    WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

    Zhuo Zhou Wen Xi Import and Export Co., Ltd. is a company mainly engaged in the export of pharmaceutical raw materials. Its parent company is (Wen Xi Pharma), including three subs

  •  Zhuozhou Wenxi import and Export Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-13111626072

    Address:Room 1710, Baoxin International Phase I, 19 Guanyun East Road, Zhuozhou, Hebei

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  • BLOOM TECH Advanced API/Technology support Saxagliptin CAS 361442-00-4

  • Casno:

    361442-00-4

    MSDS/COA Download

    BLOOM TECH Advanced API/Technology support Saxagliptin CAS 361442-00-4

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Inquiry guide 1.Please send the quantity(Weight) to us, we will arrange our sales to provide the one-for-one service for you. 2.Then we will provide the professional quotation list for you, it will be including all the factors in who

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  •  Shaanxi BLOOM TECH Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-29-86470566

    Address:Block A of Central Mansion, No.113 of Weiyang Rd, ETDZ, Xi'an, Shaanxi 710016, China

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  • Boc-3-Hydroxy-1-adamantyl-D-glycin  CAS NO 361442-00-4

  • Casno:

    361442-00-4

    MSDS/COA Download

    Boc-3-Hydroxy-1-adamantyl-D-glycin CAS NO 361442-00-4

    Min.Order: 10 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Country of origin : China Port: Shanghai Shenzhen Qingdao Hongkong PackAge: Zip lock Bag , Vacuum sealed foil packaging, Carton packing ,Export grade fiber drum or as customers’ requirement. Purity: 99%min Storage: keep in dry and c

    HUBEI AOKS BIO-TECH CO.,LTD is located in Hubei province of China.We specialized in Active pharmaceutical ingredient,pharmaceutical intermediates,veterinary drug intermediates and

  •  HUBEI AOKS BIO-TECH CO.,LTD

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-27-52345788

    Address:28F,China Construction Third Bureau,Wuhan,Hubei Province, China

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  • Boc-3-Hydroxy-1-adamantyl-D-glycine

  • Casno:

    361442-00-4

    Boc-3-Hydroxy-1-adamantyl-D-glycine

    Min.Order: 1 Gram

    FOB Price:  USD $ 12.0-12.0/Gram

    Product Description Product Name Boc-3-Hydroxy-1-adamantyl-D-glycine CAS No. 361442-00-4 Appearance White powder

    Jinan Finer Chemical Co., Ltd is established under the support of Jinan city government, so it has many advantages in company credibility, finance safe, product quality control and

  •  Jinan Finer Chemical Co., Ltd

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-531-88989536

    Address:New Material Industry Park, Jinan Ciyt, China

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  • High purity Boc-3-Hydroxy-1-adamantyl-D-glycine CAS No.:361442-00-4

  • Casno:

    361442-00-4

    High purity Boc-3-Hydroxy-1-adamantyl-D-glycine CAS No.:361442-00-4

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 2.0-2.0/Kilogram

    Boc-3-Hydroxy-1-adamantyl-D-glycine CAS No.:361442-00-4 Name: Boc-3-Hydroxy-1-adamantyl-D-glycine Synonyms (alphaS)-alpha-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-hydroxytricyclo[3.3.1.1(3,7)]decane-1-acetic acid Molecul

    HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketi

  •  Hangzhou Think Chemical Co. Ltd

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:86-571-89986307/81956191/81956084/81956192

    Address:Room 719 Building D Meidu Plaza 789 Moganshan Road

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  • Boc-3-Hydroxy-1-adamantyl-D-glycine 361442-00-4

  • Casno:

    361442-00-4

    Boc-3-Hydroxy-1-adamantyl-D-glycine 361442-00-4

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0/Kilogram

    1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

    Shanghai Upbio Tech Co.,Ltd (Former Onchem (China)Co.,Ltd) is a comprehensive manufacturer and an international distribution of chemicals throughout the world, The predecessor of

  •  Shanghai Upbio Tech Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-21-52196435

    Address:No.2 Floor,No.979 Yunhan Rd,Nicheng,Pudong New Area,Shanghai,China

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  • Organic Intermediate Boc-3-Hydroxy-1-adamantyl-D-glycine 361442-00-4

  • Casno:

    361442-00-4

    Organic Intermediate Boc-3-Hydroxy-1-adamantyl-D-glycine 361442-00-4

    Min.Order: 10 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

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    WUHAN WONDA PHARMACEUTICAL AND CHEMICAL LIMITED is specializing in custom synthesis, manufacture and import & export of nootropics, herbal extract, OLED etc. Wuhan Wonda Pharm & Ch

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    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:027-84306245

    Address:Wuhan Private Science and Technology Park , Wuhan, China

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  • (2S)-2-((tert-Butoxycarbonyl)amino)-2-(3-hydroxyadamantan-1-yl)acetic acid factory

  • Casno:

    361442-00-4

    (2S)-2-((tert-Butoxycarbonyl)amino)-2-(3-hydroxyadamantan-1-yl)acetic acid factory

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers. Our advantages:1, High quality with competitive price:1) Standard:BP/USP/EP/Enterprise standard2) All Purity≥99%3) We are manufacturer

    Shaanxi Mingqi Chemical Co., Ltd is committed to the development of import and export trade in the production, operation and plant extracts of pharmaceutical raw materials and inte

  •  Shaanxi Mingqi Chemical Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:18092428356

    Address:Weiyang District

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  • Boc-3-Hydroxy-1-adamantyl-D-glycine

  • Casno:

    361442-00-4

    Boc-3-Hydroxy-1-adamantyl-D-glycine

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 100.0-150.0/Kilogram

    Our company: Wuhan Monad Medicine Tech Co.,LTD is a research and development, production, sales in one high-tech company, own about 100 kinds of products, can provide about more than 30000 kinds of products.

    Wuhan Monad Medicine Tech Co.,LTD is a research and development, production, sales in one high-tech company, own about 100 kinds of products, can provide about more than 30000 kind

  •  Wuhan Monad Medicine Tech Co.,LTD

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+8613397160123

    Address:13th Floor, Tower B, Century Plaza, Zhongnan Road, Wuchang District, Wuhan, China.

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  • Boc-3-Hydroxy-1-adamantyl-D-glycine 361442-00-4

  • Casno:

    361442-00-4

    MSDS/COA Download

    Boc-3-Hydroxy-1-adamantyl-D-glycine 361442-00-4

    Min.Order: 1 Metric Ton

    FOB Price:  USD $ 7.0-7.0/Metric Ton

    Product Name: Boc-3-Hydroxy-1-adamantyl-D-glycine Synonyms: (alphaS)-alpha-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid;Boc-3-Hydroxy-1-adamantyl-D-glycine;(S)- N- Boc- 3- hydroxyadaman

    Career Henan Chemical Co, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded t

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    Business Type:Lab/Research institutions

    Tel:+86-371-86658258

    Address:Building 10 of Innovation Park, East District of the National University Science Park

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  • Boc-3-Hydroxy-1-adamantyl-D-glycine;Saxagliptin  Intermediate CAS:361442-00-4 from Fandachem

  • Casno:

    361442-00-4

    Boc-3-Hydroxy-1-adamantyl-D-glycine;Saxagliptin Intermediate CAS:361442-00-4 from Fandachem

    Min.Order: 0 Metric Ton

    FOB Price:  USD $ 0.0-0.0/Metric Ton

    Hangzhou Fanda Chemical Co.,Ltd (FandaChem) , a China-based chemical company, specialize in exporting Boc-3-Hydroxy-1-adamantyl-D-glycine;Saxagliptin Intermediate CAS:361442-00-4 ;Please contact us by email freely. We are leading exporter i

    Welcome to Hangzhou Fandachem Co.,Ltd (www.FandaChem.com) Hangzhou Fandachem Co.,Ltd (Fandachem),an experienced and professional China-based Fine Chemical supplier. We supply the

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    China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+86-571-28800458

    Address:Room 5010, No.9 YanAn Road,Hangzhou,Zhejiang,China

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  • Boc-3-Hydroxy-1-Adamantyl-D-Glycine

  • Casno:

    361442-00-4

    Boc-3-Hydroxy-1-Adamantyl-D-Glycine

    Min.Order: 0

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    Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

    Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, special chemicals and OLED materials &

  •  Xiamen Hisunny Chemical Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:86-592-3327115

    Address:Unit 603,No.879,Xiahe Road,Meixin Building,Xiamen,China

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  • Boc-3-Hydroxy-1-adamantyl-D-glycine

  • Casno:

    361442-00-4

    Boc-3-Hydroxy-1-adamantyl-D-glycine

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0/Kilogram

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    Enbridge PharmTech Co., Ltd. is an innovative company integrated with R&D, manufacturing, marketing and distribution of intermediates and fine chemicals, mainly used to pharmaceuti

  •  EnBridge PharmTech Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-510-83591909

    Address:Huishan Zone, Wuxi City, Jiangsu Province, P.R.China

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  • ISO 9001   National Research Platform CAS No.  361442-00-4

  • Casno:

    361442-00-4

    ISO 9001 National Research Platform CAS No. 361442-00-4

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    1. Subsidiary of Institute of Chemistry, Henan Academy of Sciences, national research platform;2. About 30 years’ experience in this field since 1983;3. An experienced R&D team consisting of Doctors and Masters;4. Various types of analytical instrume

    Zhengzhou Kingorgchem Chemical Technology Co., Ltd. was founded on the basis of Organophosphorus Chemistry Lab of Institute of Chemistry Henan Academy of Sciences in 2015. The

  •  Zhengzhou Kingorgchem Chemical Technology Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-371-65511936

    Address:NO.56,Hongzhuan Road

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  • Boc-3-Hydroxy-1-adamantyl-D-glycine

  • Casno:

    361442-00-4

    Boc-3-Hydroxy-1-adamantyl-D-glycine

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 1.0-100000.0/Kilogram

    Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

    AFINE CHEMICALS LIMITED is specialized in the fine chemicals and pharmaceuticals and we have enjoyed great popularity in world markets. Since 2005, we have been rapidly growing to

  •  Afine Chemicals Limited

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-85134551

    Address:No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China

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  • Boc-3-Hydroxy-1-adamantyl-D-glycine

  • Casno:

    361442-00-4

    Boc-3-Hydroxy-1-adamantyl-D-glycine

    Min.Order: 10 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    product name :Boc-3-Hydroxy-1-adamantyl-D-glycine CAS:361442-00-4 Appearance:off-white to white powder Storage:keep from moisture,sealed in container container,room temperature. Package:on the requirement of clients Application:saxagliptin interme

    Hangzhou Maytime Bio-Tech Co.,Ltd. specialize in R&D, manufacturing and selling kinds of pharmaceutical raw material, veterinary products, pharmaceutical intermediates. Our techni

  •  Hangzhou Maytime Bio-Tech Co.,Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+86-571-88925295 88920965

    Address:No.1-2-801 Nanan Mingzhu Xiaoshan Economical and Technological Development Zone,Hangzhou ,Zhejiang,China

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  • Boc-3-Hydroxy-1-adamantyl-D-glycine

  • Casno:

    361442-00-4

    Boc-3-Hydroxy-1-adamantyl-D-glycine

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0/Kilogram

    Product Name:Boc-3-Hydroxy-1-adamantyl-D-glycine CAS No.:361442-00-4 MF:C17H27NO5 MW:325.4 EINECS No.:700-361-0 Assay : 98% Packaging: 1kg/Bag, 25kg/Drum or depends on your requirements. Shipping: Timely delivery after your payment Superio

    Zhengzhou Yuanli Biological Technology Co., Ltd. (Zhengzhou Sigma Chemical Co., Ltd.) founded in 2009, has been committed to R&D of chemical drugs, fine chemicals and new materia

  •  Zhengzhou Yuanli Biological Technology Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-371-63507389/67897895

    Address:No. 38, Qingyang Street, Zhengzhou, Henan, China

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  • Boc-3-Hydroxy-1-adamantyl-D-glycine

  • Casno:

    361442-00-4

    Boc-3-Hydroxy-1-adamantyl-D-glycine

    Min.Order: 100 Metric Ton

    FOB Price:  USD $ 0.0-0.0/Metric Ton

    Appearance:white or yellowish white flaky crystal Storage:Keep the sun from direct sunlight ;prevention against high temperature Package:As customer request Application:Used for research and industrial manufacture. Transportatio

    Triumph International Development Limilted is engaged in the API, pharmaceutical intermediates research and developmen.Adhering to the "customer first" business philosophy,we suppl

  •  Triumph International Development Limilted

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-536-7971999

    Address:Yinhai Road,Shouguang

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Specification

The CAS registry number of Boc-3-Hydroxy-1-adamantyl-D-glycine is 361442-00-4. The IUPAC name is (2S)-[(tert-butoxycarbonyl)amino](3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)ethanoic acid. In addition, the formula is C17H27NO5 and the molecular weight is 325.4.

Physical properties about Boc-3-Hydroxy-1-adamantyl-D-glycine are: (1)ACD/LogP: 1.97; (2)# of Rule of 5 Violations: 0 ; (3)#H bond acceptors: 6; (4)#H bond donors: 3; (5)#Freely Rotating Bonds: 6; (6)Polar Surface Area: 95.86 Å2; (7)Index of Refraction: 1.575; (8)Molar Refractivity: 82.911 cm3; (9)Molar Volume: 251.06 cm3; (10)Polarizability: 32.868 ×10-24cm3; (11)Surface Tension: 59.817 dyne/cm; (12)Density: 1.296 g/cm3; (13)Flash Point: 254.53 °C; (14)Enthalpy of Vaporization: 88.13 kJ/mol; (15)Boiling Point: 497.253 °C at 760 mmHg; (16)Vapour Pressure: 0 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(OC(C)(C)C)N[C@H](C(=O)O)C12CC3CC(O)(C1)CC(C2)C3
(2)InChI: InChI=1/C17H27NO5/c1-15(2,3)23-14(21)18-12(13(19)20)16-5-10-4-11(6-16)8-17(22,7-10)9-16/h10-12,22H,4-9H2,1-3H3,(H,18,21)(H,19,20)/t10?,11?,12-,16?,17?/m1/s1
(3)InChIKey: UKCKDSNFBFHSHC-ZEJPWUNMBX