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CAS No.: | 36209-51-5 | ||||||||
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Name: | 4-AMINO-5-(4-PYRIDYL)-4 H-1,2,4-TRIAZOLE-3-THIOL | ||||||||
Article Data: | 45 | ||||||||
Molecular Structure: | |||||||||
Formula: | C7H7 N5 S | ||||||||
Molecular Weight: | 193.232 | ||||||||
Synonyms: | 4H-1,2,4-Triazole-3-thiol,4-amino-5-(4-pyridyl)- (6CI); 3-(4'-Pyridyl)-4-amino-5-mercapto-1,2,4-triazole;4-Amino-3-mercapto-5-(4-pyridyl)-4H-1,2,4-triazole | ||||||||
Density: | 1.62g/cm3 | ||||||||
Melting Point: |
250-254 °C(lit.) |
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Boiling Point: | 338.9°C at 760 mmHg | ||||||||
Flash Point: | 158.7°C | ||||||||
Hazard Symbols: | |||||||||
Risk Codes: | 36/37/38 | ||||||||
Safety: |
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PSA: | 108.42000 | ||||||||
LogP: | 0.92380 |
pyridine-4-carboxylic acid
Thiocarbohydrazide
4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol
Conditions | Yield |
---|---|
Heating; | 96% |
potassium 4-pyridinyldithiocarbazate
4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol
Conditions | Yield |
---|---|
With hydrazine hydrate at 140 - 160℃; for 6h; | 80% |
With hydrazine hydrate In water for 3h; Reflux; | 80% |
With hydrazine hydrate In water Heating; | 78% |
Conditions | Yield |
---|---|
Stage #1: isoniazid With potassium hydroxide In methanol at 0 - 5℃; Stage #2: carbon disulfide In methanol at 0 - 20℃; Stage #3: With hydrazine hydrate In water Reflux; | 80% |
Stage #1: carbon disulfide; isoniazid With potassium hydroxide In ethanol at 20℃; for 12h; Stage #2: With hydrazine hydrate In water for 6h; Reflux; Stage #3: With hydrogenchloride In water Cooling; | 72% |
Stage #1: carbon disulfide; isoniazid With potassium hydroxide In ethanol at 20℃; Stage #2: With hydrazine In water for 6h; Reflux; | 72% |
5-(4-pyridinyl)-1,3,4-oxadiazole-2-thiol
4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol
Conditions | Yield |
---|---|
With hydrazine hydrate for 0.133333h; microwave irradiation; | 70% |
With hydrazine hydrate | |
Stage #1: 5-(4-pyridinyl)-1,3,4-oxadiazole-2-thiol With hydrazine hydrate at 20℃; for 2h; Stage #2: for 4h; Reflux; Stage #3: With hydrogenchloride | |
With hydrazine hydrate In ethanol Reflux; | |
With pyridine; hydrazine hydrate at 120℃; for 12h; |
4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol
Conditions | Yield |
---|---|
With hydrazine hydrate In water for 8h; Reflux; | 62% |
With hydrazine hydrate In water for 1h; Heating; Yield given; |
4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol
Conditions | Yield |
---|---|
With hydrazine hydrate In water Heating; |
isoniazid
4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: KOH / ethanol / 14 h 2: hydrazine hydrate / H2O / Heating View Scheme | |
Multi-step reaction with 2 steps 1: KOH / ethanol 2: 52 percent / N2H4 / H2O / 2 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: carbon disulphide, potassium hydroxide / ethanol 2: 80 percent / 80percent hydrazine / 6 h / 140 - 160 °C View Scheme |
pyridine-4-carboxylic acid
4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: H2SO4 2.1: H2NNH2*H2O 3.1: KOH 3.2: H2NNH2*H2O / 120 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: sulfuric acid / Reflux 2.1: hydrazine hydrate / Reflux 3.1: potassium hydroxide / methanol / 0.25 h 3.2: 3 h / 20 - 25 °C 4.1: hydrazine hydrate / water / 1 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: sulfuric acid / Reflux 2.1: hydrazine hydrate / methanol / 0.03 h / Microwave irradiation 3.1: potassium hydroxide / methanol / 0 - 5 °C 4.1: hydrazine hydrate / 0.03 h / Microwave irradiation 4.2: 0.03 h View Scheme |
isonicotinic acid ethylester
4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: H2NNH2*H2O 2.1: KOH 2.2: H2NNH2*H2O / 120 °C View Scheme | |
Multi-step reaction with 3 steps 1: hydrazine hydrate / ethanol / Reflux 2: potassium hydroxide / ethanol 3: hydrazine hydrate / water / Heating View Scheme | |
Multi-step reaction with 3 steps 1.1: hydrazine hydrate / methanol / 0.03 h / Microwave irradiation 2.1: potassium hydroxide / methanol / 0 - 5 °C 3.1: hydrazine hydrate / 0.03 h / Microwave irradiation 3.2: 0.03 h View Scheme | |
Multi-step reaction with 3 steps 1: hydrazine hydrate / ethanol / 24 h / Reflux 2: potassium hydroxide / ethanol / 12 h / 20 °C / Cooling with ice 3: hydrazine hydrate / water / 24 h / Reflux View Scheme |
isoniazid
4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium hydroxide / ethanol / 3 h / 25 °C 2: hydrazine hydrate / H2O / 1 h / Heating View Scheme |