CAS No.36304-84-4,Dimemorfan phosphate Suppliers

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Basic Information

Molecular Structure:
CAS No.:	36304-84-4
Name:	Dimemorfan phosphate
Article Data:	3

Formula:	C₁₈H₂₅N^.H₃O₄P
Molecular Weight:	353.398
Synonyms:	DIMEMORFAN PHOSPHATE;(9alpha,13alpha,14alpha)-3,17-dimethylmorphinan dihydrogen phosphate;Astomin;dimemorphan phosphate;Morphinan, 3,17-dimethyl-, (9α,13α,14α)-, phosphate (1:1)
EINECS:	252-958-6
Density:	1.07g/cm³
Melting Point:	267-269°
Boiling Point:	366.9°Cat760mmHg
Flash Point:	158.3°C
Safety:	Poison by intravenous, intraperitoneal, and subcutaneous routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Used as an antitussive agent. When heated to decomposition it emits very toxic fumes of NO_x and PO_x. See also PHOSPHATES.
PSA:	90.81000
LogP:	2.69250

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Chemistry

D-3-methyl-N-methylmorphinan phosphate(36304-84-4) exists as bitter-tasting crystals. D-3-methyl-N-methylmorphinan phosphate(36304-84-4) is slightly soluble in H₂O and methanol, and it is insoluble in acetone, ethanol, ether.
Molecular Formula: C₁₈H₂₅N^.H₃O₄P.
Molecular Weight: 353.44.
Density: 1.07g/cm³.
Boiling Point: 366.9 ℃ at 760mmHg.
Flash Point: 158.3 ℃.
Molecular Structure:

Uses

D-3-methyl-N-methylmorphinan phosphate(36304-84-4) is neuroprotective to inflammation-mediated neurodegenerative diseases through mechanisms of σ₁receptors. D-3-methyl-N-methylmorphinan phosphate(36304-84-4), an analogue of dextromethorphan, is used as nonopioid antitussive.

Toxicity Data With Reference

1.	orl-rat LD50:690 mg/kg	MEIEDD Merck Index. 10 (1983),466.
2.	ipr-rat LD50:124 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 6 (1972),1207.
3.	scu-rat LD50:556 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),345.
4.	ivn-rat LD50:57 mg/kg	MEIEDD Merck Index. 10 (1983),466.
5.	orl-mus LD50:475 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 26 (1976),353.
6.	scu-mus LD50:223 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 26 (1976),353.
7.	ivn-mus LD50:33,900 µg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 6 (1972),1207.
8.	ivn-dog LD50:35 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 26 (1976),353.

Safety Profile

Poison by intravenous, intraperitoneal, and subcutaneous routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Used as an antitussive agent. When heated to decomposition it emits very toxic fumes of NO_x and PO_x. See also PHOSPHATES.