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CAS No.: | 3637-10-3 |
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Name: | 4-HYDROXY-TEMPO |
Article Data: | 32 |
Molecular Structure: | |
Formula: | C9H19 N O2 |
Molecular Weight: | 173.255 |
Synonyms: | 1,4-Dihydroxy-2,2,6,6-tetramethylpiperidine;1-Hydroxy-2,2,6,6-tetramethyl-4-hydroxypiperidine; 4-Hydroxy-2,2,6,6-tetramethyl-N-hydroxypiperidine;OT 674; TOLH; Tempol H |
EINECS: | 218-760-9 |
Density: | 1.029 g/cm3 |
Melting Point: | 69-71 °C(lit.) |
Boiling Point: | 260.2 °C at 760 mmHg |
Flash Point: | 111 °C |
Hazard Symbols: | Xn |
Risk Codes: | 22-36/37/38 |
Safety: | 26-36 |
PSA: | 43.70000 |
LogP: | 1.32740 |
Conditions | Yield |
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With 3,3-dimethyldioxirane In acetone at 0℃; for 2h; | 99% |
With sodium tungstate; ethylenediaminetetraacetic acid; dihydrogen peroxide In water | |
With DMd In acetone | |
Multi-step reaction with 2 steps 1: sodium tungstate monohydrate; dihydrogen peroxide / methanol; water / 50 h / 20 °C / Inert atmosphere 2: phenylhydrazine / chloroform-d1 View Scheme |
Conditions | Yield |
---|---|
With formaldehyd; dihydrogen peroxide; copper(l) chloride at 30℃; for 16h; | 87% |
With ethylenediaminetetraacetic acid; β-nicotinamide adenine dinucleotide reduced; hypoxanthine; catalase; xanthine oxidase pH=7.4; Kinetics; aq. phosphate buffer; |
TEMPOL
tempol
Conditions | Yield |
---|---|
With sodium dithionite In water; acetone for 0.5h; Ambient temperature; | 80% |
With sodium L-ascorbate pH=7; | |
With air; sodium ascorbate Mechanism; spin loss rate, further nitroxide free radicals, var.:illumination, atmosphere:N2, ferric chloride; |
Conditions | Yield |
---|---|
for 48h; Heating; | A n/a B 59% |
Heating; |
Conditions | Yield |
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at 135 - 136℃; for 69h; | A n/a B 51% |
Heating; |
TEMPOL
toluene
A
tempol
B
benzyl-4-hydroxy-2,2,6,6-tetramethylpiperidinyl-1-oxyl
Conditions | Yield |
---|---|
at 143℃; for 53h; | A n/a B 30% |
Heating; |
Conditions | Yield |
---|---|
at 64℃; for 72h; Title compound not separated from byproducts; | A 20% B n/a C n/a |
Conditions | Yield |
---|---|
at 88℃; for 48h; Title compound not separated from byproducts; | A 18% B n/a C n/a |
Conditions | Yield |
---|---|
at 70℃; for 72h; Title compound not separated from byproducts; | A n/a B 15.5% C n/a |
TEMPOL
ethylbenzene
A
tempol
B
4-hydroxy-1-((1'-phenylethyl)oxy)-2,2,6,6-tetramethylpiperidine
Conditions | Yield |
---|---|
at 133℃; | A n/a B 6% |
at 133℃; for 26h; | A 12.57 g B 6% |