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Basic Information
CAS No.: 364-98-7
Name: DIAZOXIDE
Article Data: 15
Molecular Structure:
Molecular Structure of 364-98-7 (DIAZOXIDE)
Formula: C8H7 Cl N2 O2 S
Molecular Weight: 230.675
Synonyms: 4H-1,2,4-Benzothiadiazine,7-chloro-3-methyl-, 1,1-dioxide (7CI); 3-Methyl-7-chloro-1,2,4-benzothiadiazine1,1-dioxide; 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide;Diazoxide; Dizoxide; Eudemine injection; Hyperstat; Hypertonalum; Mutabase; NSC64198; NSC 76130; Proglicem; Proglycem; SRG 95213; Sch 6783
Density: 1.61g/cm3
Melting Point: >310°C
Boiling Point: 414.8°Cat760mmHg
Flash Point: 204.7°C
Solubility: Soluble in 0.1M NaOH. Insoluble in water or in methanol.
Hazard Symbols:
Risk Codes: 22-36/37/38
Safety: Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. When heated to decomposition it emits toxic fumes of Cl−, SOx, and NOx.
PSA: 66.91000
LogP: 2.52700
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    Diazoxide cas 364-98-7

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    diazoxide

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  • DIAZOXIDE

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    DIAZOXIDE

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    bulk?production Application:Pharmaceutical intermediates

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Chemistry

Molecular Formula:C8H7ClN2O2S
Molecular Weight:230.68
Density:1.61g/cm3
Boiling Point:414.8°C at 760mmHg
Flash Point:204.7°C
Properties:Crystals from dilute alc.
Mp: 330–331°C
solubility:0.1 M NaOH: soluble

DIAZOXIDE's Synonyms: 2h-1,2,4-benzothiadiazine,7-chloro-3-methyl-,1,1-dioxide;7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine1;7-cloro-3-metil-2h-1,2,4-benzotiodiazina-1,1-diossido;diazossido;dizoxide;Eudemine;hyperstat;mutabase

Toxicity Data With Reference

1.   

orl-rat LD50:980 mg/kg

   AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 143 (1963),446.
2.   

ipr-rat LD50:510 mg/kg

   AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 143 (1963),446.
3.   

orl-mus LD50:444 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 136 (1962),344.
4.   

ipr-mus LD50:326 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 136 (1962),344.
5.   

ivn-mus LD50:228 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 136 (1962),344.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. When heated to decomposition it emits toxic fumes of Cl?, SOx, and NOx.

DIAZOXIDE's Safety Information
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  22-26-36
WGK Germany  3
RTECS  DK8185000

Specification

DIAZOXIDE's Handling And Storage Precautions:
store in tight container. should be handled/stored per label/other instructions to ensure product integrity. use
w/adequate ventilation.

DIAZOXIDE's First Aid:
Inhalation: remove to fresh air. give cpr/oxygen if needed.
Eyes/skin: flush w/copious amounts of water.
Ingestion:flush mouth out w/water. hypersensitivity reactions require immediate medical attent ion. obtain medical
attention in all cases.