Products Categories
| CAS No.: | 367-21-5 |
|---|---|
| Name: | 3-Chloro-4-fluoroaniline |
| Molecular Structure: | |
|
|
|
| Formula: | C6H5ClFN |
| Molecular Weight: | 145.564 |
| Synonyms: | Benzenamine, 3-chloro-4-fluoro-;3-chloro-4-fluoro-aniline;Aniline, 3-chloro-4-fluoro-;3-Chloro-4-fluoro-phenylamine; |
| EINECS: | 206-682-8 |
| Density: | 1.349 g/cm3 |
| Melting Point: | 42-44 °C(lit.) |
| Boiling Point: | 227.5 °C at 760 mmHg |
| Flash Point: | 99.4 °C |
| Solubility: | 10 g/L (20 °C) in water |
| Appearance: | dark purple to black solid |
| Hazard Symbols: |
 T,  Xn,  Xi
|
| Risk Codes: | 23/24/25-33-36/37/38-20/21/22 |
| Safety: | 36/37/39-45-26 |
| Transport Information: | UN 2811 6.1/PG 2 |
| PSA: | 26.02000 |
| LogP: | 2.64250 |
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
- 43224-75-52,2,6,6-Tetramethyl-4-(2-propyleneoxy) Piperidine
| Conditions | Yield |
|---|---|
| With hydrogen In ethanol; water at 25℃; under 760.051 Torr; for 3h; Autoclave; | 99.9% |
| With sodium tetrahydroborate; cyclohexanediamine-Pd-β-cyclodextrin In water at 20℃; for 3h; Sealed tube; | 96% |
| With hydrazine hydrate In ethanol at 100℃; under 760.051 Torr; for 8h; Time; Sealed tube; chemoselective reaction; | 94.7% |
- 367-21-5
3-chloro-4-fluorophenylamine
| Conditions | Yield |
|---|---|
| With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate at 20℃; for 0.25h; chemoselective reaction; | 86% |
- 119951-96-1
(3-chloro-4-fluoro-phenyl)-carbamic acid tert-butyl ester
- 367-21-5
3-chloro-4-fluorophenylamine
| Conditions | Yield |
|---|---|
| With methanol; oxalyl dichloride at 20℃; for 2h; | 80% |
| Conditions | Yield |
|---|---|
| With Piperonyl butoxide; hydrogen fluoride Yields of byproduct given; | A 34% B n/a |
- 367-21-5
3-chloro-4-fluorophenylamine
| Conditions | Yield |
|---|---|
| (i) PCl5, (ii) aq. HCl; Multistep reaction; |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: iron-powder / Einleiten von Chlor 2: titanium (III)-chloride; water View Scheme | |
| Multi-step reaction with 2 steps 1: Cl2, FeCl3 2: Fe, aq. NH4Cl View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: hydrogenchloride; sodium nitrite / water / 0.5 h 2: trifluoromethan; fluorosulfonyl fluoride / 70 °C 3: hydrogenchloride / water / 2 h / 50 °C View Scheme |
- 367-21-5
3-chloro-4-fluorophenylamine
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water at 50℃; for 2h; |
- 367-21-5
3-chloro-4-fluorophenylamine
- 87-13-8
diethyl 2-ethoxymethylenemalonate
- 70032-30-3
diethyl 2-[(3-chloro-4-fluorophenylamino)methylene]malonate
| Conditions | Yield |
|---|---|
| at 120 - 130℃; for 2h; | 100% |
| for 0.0333333h; Gould-Jacob reaction; Irradiation; | 99% |
| at 110℃; for 1h; Microwave irradiation; | 99% |
- 367-21-5
3-chloro-4-fluorophenylamine
- 24424-99-5
di-tert-butyl dicarbonate
- 119951-96-1
(3-chloro-4-fluoro-phenyl)-carbamic acid tert-butyl ester
| Conditions | Yield |
|---|---|
| Stage #1: 3-chloro-4-fluorophenylamine With triethylamine In tetrahydrofuran; water at 20℃; for 0.0833333h; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran; water at 0 - 20℃; for 6h; | 100% |
| With 1-butyl-3-methylimidazolium trifluoromethanesulfonimide at 30 - 35℃; for 0.25h; neat (no solvent); chemoselective reaction; | 95% |
| In water at 30 - 35℃; for 6h; | 92% |
- 1309-42-8Magnesium hydroxide
- 140-88-5Ethyl acrylate
- 28920-43-69-Fluorenylmethyl chloroformate
- 98-88-4Benzoyl chloride
- 104-94-9p-Anisidine
- 937-14-43-Chloroperoxybenzoic acid
- 5329-14-6Sulfamic acid
- 89-78-1Cyclohexanol,5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-rel-
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
What can I do for you?
Get Best Price
Chemistry
Molecular Structure:
.png)
Molecular Formula: C6H5ClFN
Molecular Weight: 145.562
IUPAC Name: 3-Chloro-4-fluoroaniline
Synonyms of 3-Chloro-4-fluoroaniline (CAS NO.367-21-5): Aniline, 3-chloro-4-fluoro- ; EINECS 206-682-8 ; NSC 10290 ; Benzenamine, 3-chloro-4-fluoro-
CAS NO: 367-21-5
Product Categories: Drug Intermediates ; Anilines, Aromatic Amines and Nitro Compounds ; Fluorobenzene ; C2 to C6 ; Nitrogen Compounds ; ChloroChemical Class ; FluoroMore...Close... ; Alpha Sort ; Amines ; Analytical Standards ; AromaticsChemical Class ; AromaticsVolatiles/ Semivolatiles ; C ; CAlphabetic ; CHChemical Class ; Chemical Class ; Halogenated ; Aniline series
Melting point: 42-44 °C
Index of Refraction: 1.569
Molar Refractivity: 35.37 cm3
Molar Volume: 107.8 cm3
Surface Tension: 42.9 dyne/cm
Density: 1.349 g/cm3
Flash Point: 99.4 °C
Enthalpy of Vaporization: 46.41 kJ/mol
Boiling Point: 227.5 °C at 760 mmHg
Vapour Pressure: 0.0773 mmHg at 25°C
Uses
3-Chloro-4-fluoroaniline (CAS NO.367-21-5) is used as the important intermediates for Norfloxacin Synthesis.
Safety Profile
Safety Information about 3-Chloro-4-fluoroaniline (CAS NO.367-21-5):
Hazard Codes: 
T,
Xi,Xn
Risk Statements:
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed
R33: Danger of cumulative effects
R36/37/38: Irritating to eyes, respiratory system and skin
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed
Safety Statements:
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45:I n case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 2