CAS No.389-08-2,Nalidixic acid Suppliers

Products Categories

Pharmaceutical (60)
Others (41)
Organic Chemicals (19)
Reagent (9)
Materials (4)
Plant Extract (2)

Basic Information

Molecular Structure:
CAS No.:	389-08-2
Name:	Nalidixic acid
Article Data:	29

Formula:	C₁₂H₁₂N₂O₃
Molecular Weight:	232.239
Synonyms:	1,4-Dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylicacid;1-Ethyl-7-methyl-1,8-naphthyridin-4-one-3-carboxylic acid;1-Ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid;3-Carboxy-1-ethyl-7-methyl-1,8-naphthyridin-4-one;1,8-Naphthyridine-3-carboxylicacid, 1-ethyl-1,4-dihydro-7-methyl-4-oxo-;Dixiben;Eucistin;Innoxalomn;Nalidicron;Nalidixan;Nalidixin;Nalitucsan;Nalurin;Nelidix;Nevigramon;Poleon;Specifin;Urisal;Uroman;Wintomylon;
EINECS:	206-864-7
Density:	1.331 g/cm³
Melting Point:	227-229 °C(lit.)
Boiling Point:	413.1 °C at 760 mmHg
Flash Point:	203.636 °C
Solubility:	Soluble in chloroform, slightly soluble in alcohol, strong aqueous alkali, hardly soluble in water and ether
Appearance:	crystalline powder
Hazard Symbols:	Xn
Risk Codes:	63-42/43-40-20/21/22
Safety:	22-36/37-45-24
PSA:	72.19000
LogP:	1.42300

Raw Materials

Downstream Products

Total:116 Page 1 of 4 1 2 3 4 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 389-08-2

Consensus Reports

EPA Genetic Toxicology Program.

Specification

The Nalidixic acid, with the CAS registry number 389-08-2, is also known as 1,4-Dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid. It belongs to the product categories of Heterocyclic Compounds; Antibiotics for Research and Experimental Use; Biochemistry; Quinolones (Antibiotics for Research and Experimental Use); Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals. Its EINECS number is 206-864-7. This chemical's molecular formula is C₁₂H₁₂N₂O₃ and molecular weight is 232.24. What's more, its systematic name is 1-Ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid. Its classification codes are: (1)Anti-Infective Agents; (2)Antibacterial; (3)Drug / Therapeutic Agent; (4)Enzyme Inhibitors; (5)Human Data; (6)Mutation data; (7)Nucleic Acid Synthesis Inhibitors; (8)Reproductive Effect; (9)Tumor data. This chemical is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the subunit of bacterial DNA gyrase. It is also a tool in studies as a regulation of bacterial division. This chemical should be sealed and stored at the temperature of 0 - 6 °C. Moreover, it should be protected from light and air.

Physical properties of Nalidixic acid are: (1)ACD/LogP: 0.025; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.58; (4)ACD/LogD (pH 7.4): -1.54; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 6.12; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 5; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 70.5 Å²; (13)Index of Refraction: 1.605; (14)Molar Refractivity: 60.074 cm³; (15)Molar Volume: 174.429 cm³; (16)Polarizability: 23.815×10^-24cm³; (17)Surface Tension: 59.33 dyne/cm; (18)Density: 1.331 g/cm³; (19)Flash Point: 203.636 °C; (20)Enthalpy of Vaporization: 70.203 kJ/mol; (21)Boiling Point: 413.1 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25°C.

Preparation: this chemical can be prepared by 2-amino-5-methyl-pyridine which is derived from 2-methylpyridine, and then combines with ethyl orthoformate and diethyl malonate to get N-(2-methyl-5-amino pyridine). After cyclization at 260-270°C, hydrolyzation in sodium hydroxide to get 7-methyl-1,8-nalidixic 4-hydroxy-3-hydroxy acid. Finally, use bromoethane to do N-alkylation reaction and the product is isomerized to Nalidixic acid.

Uses of Nalidixic acid: it can be used to produce 1-ethyl-3-iodo-7-methyl-1H-[1,8]naphthyridin-4-one by heating. It will need reagents I₂, lead tetraacetate and solvent CCl₄ with the reaction time of 30 min. The yield is about 61.9%.

Nalidixic acid can be used to produce 1-ethyl-3-iodo-7-methyl-1H-[1,8]naphthyridin-4-one by heating

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful by inhalation, in contact with skin and if swallowed. It has a limited evidence of a carcinogenic effect and may cause sensitisation by inhalation and skin contact. This substance has a possible risk of harm to the unborn child. You should not breathe dust. When using it, you must avoid contact with eyes. When using it, you need wear suitable protective gloves and eye/face protection. In case of accident or if you feel unwell, you must seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: O=C\2c1c(nc(cc1)C)N(/C=C/2C(=O)O)CC
(2)Std. InChI: InChI=1S/C12H12N2O3/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14/h4-6H,3H2,1-2H3,(H,16,17)
(3)Std. InChIKey: MHWLWQUZZRMNGJ-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	unreported	1200mg/kg/20D (1200mg/kg)	BLOOD: OTHER CHANGES	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 414, 1969.
mouse	LD50	intraperitoneal	600mg/kg (600mg/kg)		United States Patent Document. Vol. #4552882,
mouse	LD50	intravenous	101mg/kg (101mg/kg)		Antimicrobial Agents and Chemotherapy Vol. -, Pg. 117, 1970.
mouse	LD50	oral	572mg/kg (572mg/kg)		Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
mouse	LD50	subcutaneous	500mg/kg (500mg/kg)		Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat	LD50	intraperitoneal	319mg/kg (319mg/kg)		Antimicrobial Agents and Chemotherapy Vol. -, Pg. 117, 1970.
rat	LD50	intravenous	1160mg/kg (1160mg/kg)		Drugs in Japan Vol. -, Pg. 908, 1995.
rat	LD50	oral	2040mg/kg (2040mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Chemotherapy Vol. 28(Suppl,
rat	LD50	subcutaneous	1584mg/kg (1584mg/kg)		Antimicrobial Agents and Chemotherapy Vol. -, Pg. 117, 1970.
women	TDLo	oral	40mg/kg (40mg/kg)	BRAIN AND COVERINGS: INCREASED INTRACRANIAL PRESSURE BEHAVIORAL: COMA	Acta Medica Scandinavica. Vol. 216, Pg. 237, 1984.
women	TDLo	oral	160mg/kg/2D (160mg/kg)	SKIN AND APPENDAGES (SKIN): SWEATING: OTHER ENDOCRINE: HYPERGLYCEMIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	British Medical Journal. Vol. 2, Pg. 1518, 1977.
women	TDLo	oral	560mg/kg (560mg/kg)	BEHAVIORAL: COMA CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE	Intensive Care Medicine. Vol. 5, Pg. 141, 1979.