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396-01-0

Basic Information
CAS No.: 396-01-0
Name: 2,4,7-Triamino-6-phenylpteridine
Article Data: 16
Molecular Structure:
Molecular Structure of 396-01-0 (2,4,7-Triamino-6-phenylpteridine)
Formula: C12H11N7
Molecular Weight: 253.266
Synonyms: Pteridine,2,4,7-triamino-6-phenyl- (8CI);2,4,7-Triamino-6-phenylpteridine;6-Phenyl-2,4,7-triaminopteridine;Ademin;Ademine;Diren;Ditak;Diurene;Dyren;Dyrenium;Dytac;Jatropur;NSC 77625;Noridil;Pterofen;Pterophene;SKF8542;Taturil;Teriam;Teridin;Tri-Span;Triampur;Triamteren;Triteren;Urocaudal;
EINECS: 206-904-3
Density: 1.502 g/cm3
Melting Point: 316 °C
Boiling Point: 573.4 °C at 760 mmHg
Flash Point: 335.5 °C
Solubility: <0.1 g/100 mL at 20 °C in water
Appearance: Yellow solid
Hazard Symbols: HarmfulXn, ToxicT, FlammableF
Risk Codes: 22-36/37/38-36/38-23/25
Safety: 26-36/37/39-45-33-24-16-7
Transport Information: UN 2811
PSA: 129.62000
LogP: 2.57700
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  • Triamterene  396-01-0  low price manufacturer

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Chemistry

CBNumber: CB0663775
Chemical Name: 2,4,7-Triamino-6-phenylpteridine
Molecular Formula: C12H11N7
Formula Weight: 253.26
CAS No: 396-01-0
Synonyms:6-PHENYL-PTERIDINE-2,4,7-TRIAMINE;6-PHENYL-2,4,7-PTERIDINETRIAMINE;6-PHENYL-2,4,7-TRIAMINO PTERIDINE;ADEMINE;2,4,7-TRIAMINO-6-PHENYLPTERIDINE;TRIAMTERENE;2,4,7-triamino-6-fenilpteridina;2,4,7-triamino-6-phenyl-pteridin
molecular structure:

mp :316°C
Fp :11 °C
storage temp:2-8°C

2,4,7-Triamino-6-phenylpteridine  relates to pharmaceutical preparations with cardiac, particularly anti-arrhythmic activity. These preparations comprise, as an active principle, at least one compound of formula I: ##STR1## where R represents a lipophilic radical. The pharmaceutical compositions may comprise 2,4,7-Triamino-6-phenylpteridine  in the presence of other pharmaceutical excipients and adjuvants.

Toxicity Data With Reference

1.   

otr-ham:emb 25 mg/L

   ENMUDM    Environmental Mutagenesis. 8 (Suppl 6)(1986),4.
2.   

cyt-ham:lng 2800 µg/L

   GMCRDC    Gann Monograph on Cancer Research. 27 (1981),95.
3.   

orl-wmn TDLo:42 mg/kg/3W-I:SYS

   MJAUAJ    Medical Journal of Australia. 147 (1987),262.
4.   

orl-rat LD50:400 mg/kg

   YAKUD5    Gekkan Yakuji. Pharmaceuticals Monthly. 21 (1979),775.
5.   

ipr-rat LD50:200 mg/kg

   YAKUD5    Gekkan Yakuji. Pharmaceuticals Monthly. 21 (1979),775.
6.   

orl-mus LD50:285 mg/kg

   FRXXBL    French Demande Patent Document. (Commissioner of Patents and Trademarks, Washington, DC 20231) #2314719 .
7.   

ipr-mus LD50:249 mg/kg

   NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),519.
8.   

scu-mus LD50:620 mg/kg

   NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),519.

Safety Profile

Poison by ingestion and intraperitoneal routes. Moderately toxic by subcutaneous route. Human systemic effects: body temperature increase, hepatitis. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Harmful if swallowed
Do not breathe dust
Wear suitable protective clothing and gloves