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| CAS No.: | 39831-55-5 |
|---|---|
| Name: | Amikacin disulfate salt |
| Molecular Structure: | |
|
|
|
| Formula: | C22H43N5O13.2(H2SO4) |
| Molecular Weight: | 781.768 |
| Synonyms: | Amikacin disulfate salt;4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-,sulfate (1:2) (salt) (9CI);Amiglyde V;Amika;Amikacin disulfate;Amikacinsulfate;Amikavet;Amikin;Amiklin;Antibiotic BB-K 8 sulfate;Biklin;Biodacyn;Fabianol;Grasil;Kaminax;Mikavir;Pierami; |
| EINECS: | 254-648-6 |
| Melting Point: | 220-230 °C |
| Boiling Point: | 981.8 °C at 760 mmHg |
| Flash Point: | 547.6 °C |
| Solubility: | H2O: 50 mg/mL, clear, colorless |
| Appearance: | white |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36 |
| PSA: | 497.90000 |
| LogP: | -4.37610 |
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amikacin
- 39831-55-5
amikacin sulfate
| Conditions | Yield |
|---|---|
| With sulfuric acid In ethanol; water at 10℃; for 6h; Temperature; | 91.5% |
- 39831-55-5
amikacin sulfate
- 1448168-07-7
3-C-azido amikacin
| Conditions | Yield |
|---|---|
| With imidazole-1-sulfonyl azide hydrochloride In water at 20℃; for 40h; pH=7; regioselective reaction; | 29% |
- 39831-55-5
amikacin sulfate
- 37517-28-5
amikacin
| Conditions | Yield |
|---|---|
| With Amberlite ion exchange resin (OH-form) In water for 1h; |
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- 3999-38-0Borane-2-picoline complex
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Chemistry
Molecular Structure of Antibiotic bb-k8 sulfate (CAS NO.39831-55-5):
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IUPAC Name: (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide
Product Name: Amikacin disulfate salt
Molecular formula: C22H47N5O21S2
Molecular Weight: 781.76
EINECS: 254-648-6
Melting point:220-230 °C
Flash Point: 547.6 °C
Enthalpy of Vaporization: 162.21 kJ/mol
Boiling Point: 981.8 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C
Storage temp: 2-8°C
Solubility: H2O: 50 mg/mL
InChI
InChI=1/C22H43N5O13.2H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;2*1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);2*(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;;/m0../s1
Smiles
O([C@H]1[C@@H](C[C@@H]([C@H]([C@@H]1O)O[C@H]1O[C@@H]([C@@H](O)[C@@H]([C@H]1O)O)CN)N)NC([C@H](CCN)O)=O)[C@H]1O[C@@H]([C@@H](O)[C@@H]([C@H]1O)N)CO.S(O)(O)(=O)=O.S(O)(O)(=O)=O
Product Categories: Active Pharmaceutical Ingredients
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intramuscular | > 667mg/kg (667mg/kg) | Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 125, 1977. | |
| dog | LD50 | intravenous | 383mg/kg (383mg/kg) | Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 125, 1977. | |
| monkey | LD50 | intramuscular | > 1335mg/kg (1335mg/kg) | Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 125, 1977. | |
| mouse | LD50 | intramuscular | 1247mg/kg (1247mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986. |
| mouse | LD50 | intraperitoneal | 2930mg/kg (2930mg/kg) | Japanese Journal of Antibiotics. Vol. 28, Pg. 415, 1975. | |
| mouse | LD50 | intravenous | 181mg/kg (181mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA | Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986. |
| mouse | LD50 | oral | > 10679mg/kg (10679mg/kg) | Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 125, 1977. | |
| mouse | LD50 | subcutaneous | 2470mg/kg (2470mg/kg) | Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 125, 1977. | |
| rabbit | LD50 | intramuscular | > 3gm/kg (3000mg/kg) | Japanese Journal of Antibiotics. Vol. 28, Pg. 415, 1975. | |
| rabbit | LD50 | intravenous | 248mg/kg (248mg/kg) | Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 125, 1977. | |
| rabbit | LD50 | oral | > 3gm/kg (3000mg/kg) | Drugs in Japan Vol. -, Pg. 45, 1990. | |
| rat | LD50 | intramuscular | 2244mg/kg (2244mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986. |
| rat | LD50 | intraperitoneal | 3500mg/kg (3500mg/kg) | Japanese Journal of Antibiotics. Vol. 28, Pg. 415, 1975. | |
| rat | LD50 | intravenous | 234mg/kg (234mg/kg) | Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 125, 1977. | |
| rat | LD50 | oral | > 4gm/kg (4000mg/kg) | Japanese Journal of Antibiotics. Vol. 28, Pg. 415, 1975. | |
| rat | LD50 | subcutaneous | 3604mg/kg (3604mg/kg) | Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 125, 1977. |
Safety Profile
Poison by intravenous route. Moderately toxic by intraperitoneal and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also sulfates.
Hazard Codes: 
Xi
The Risk Statements information of Antibiotic bb-k8 sulfate (CAS NO.39831-55-5):
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of Antibiotic bb-k8 sulfate (CAS NO.39831-55-5) :
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
WGK Germany: 2
RTECS: WK1961200
F: 3-10
Specification
Antibiotic bb-k8 sulfate , with CAS number of 39831-55-5, can be called (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-(3-amino-3-deoxy-alpha-D-glucopyranosyloxy)-4-(6-amino-6-deoxy-alpha-D-glucopyranosyloxy)-3-hydroxycyclohexyl]-2-hydroxybutanamide disulfate ; (R)-4-amino-N-((1R,2R,3S,4R,5S)-5-amino-2-((3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)-4-((3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxy-tetrahydro-2H-pyran-2-yloxy)-3-hydroxycyclohexyl)-2-hydroxybutanamide ; amikacin bis(sulphate) ; Amikacin disulfate salt .