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CAS No.: | 41202-77-1 |
---|---|
Name: | 1-(2,3-Dichlorophenyl)-piperazine hydrochloride |
Article Data: | 12 |
Molecular Structure: | |
Formula: | C10H12Cl2N2 |
Molecular Weight: | 231.125 |
Synonyms: | 4-(2,3-Dichlorophenyl)piperazine;DCPP;N-(2,3-Dichlorophenyl)piperazine;Piperazine,1-(2,3-dichlorophenyl)-; |
Density: | 1.272 g/cm3 |
Melting Point: | 242-244ºC |
Boiling Point: | 365.1 °C at 760 mmHg |
Flash Point: | 174.6 °C |
Appearance: | Brown Oil |
Hazard Symbols: | R36/37/38:; |
Risk Codes: | R36/37/38 |
PSA: | 15.27000 |
LogP: | 2.79680 |
2,3-dichloroaniline
N,N-bis(chloro-2-ethyl)amine
1-(2,3-dichlorophenyl)piperazine
Conditions | Yield |
---|---|
Stage #1: 2,3-dichloroaniline; N,N-bis(chloro-2-ethyl)amine With tetrabutylammomium bromide; toluene-4-sulfonic acid In 5,5-dimethyl-1,3-cyclohexadiene for 48h; Stage #2: With ammonium hydroxide pH=6 - 7; | 88% |
Conditions | Yield |
---|---|
With tris(dibenzylideneacetone)dipalladium (0); (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate In toluene for 18h; Heating; | A 62% B 7% |
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); 2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl; sodium t-butanolate In 1,4-dioxane at 100℃; for 0.166667h; | 37% |
Conditions | Yield |
---|---|
With phosphorus pentoxide; triethylamine hydrochloride at 220℃; for 4h; | 31% |
With phosphorus pentaoxide; triethylamine hydrochloride at 200℃; for 3h; | 21% |
Stage #1: 2,3-dichloroaniline; 2,2'-iminobis[ethanol] With phosphorus pentoxide; triethylamine hydrochloride at 220℃; for 4h; Inert atmosphere; Stage #2: With sodium hydroxide In water at 0℃; pH=10; | 15% |
Conditions | Yield |
---|---|
With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium (0) In toluene at 60 - 70℃; Buchwald amination; |
1-(2,3-dichlorophenyl)piperazine
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane; water for 0.5h; |
1-(2,3-dichlorophenyl)piperazine
Conditions | Yield |
---|---|
With copper dichloride In methanol; water at 80℃; |
bis-(2-chloroethyl)amine hydrochloride
2,3-dichloroaniline
1-(2,3-dichlorophenyl)piperazine
Conditions | Yield |
---|---|
With potassium iodide at 150℃; Inert atmosphere; |
5-hexynyl p-toluenesulfonate
1-(2,3-dichlorophenyl)piperazine
Conditions | Yield |
---|---|
With potassium carbonate; sodium iodide In acetone for 12h; Reflux; | 98% |
1-(2,3-dichlorophenyl)piperazine
2-(6-bromohexyl)–2H-naphtho[1,8-cd]isothiazole1,1-dioxide
Conditions | Yield |
---|---|
Stage #1: 1-(2,3-dichlorophenyl)piperazine; 2-(6-bromohexyl)–2H-naphtho[1,8-cd]isothiazole1,1-dioxide With tetrabutylammomium bromide; potassium carbonate; sodium hydroxide In acetonitrile for 0.0138889h; Microwave irradiation; Stage #2: With hydrogenchloride In 1,4-dioxane; acetone | 98% |
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Molecular Structure of 1-(2,3-Dichlorophenyl)-piperazine hydrochloride (CAS NO.41202-77-1):
IUPAC Name: 1-(2,3-dichlorophenyl)piperazin-4-ium
Empirical Formula: C10H13Cl3N2
Molecular Weight: 267.5826
H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 1
Polar Surface Area: 3.24 Å2
Density: 1.272 g/cm3
Flash Point: 174.6 °C
Enthalpy of Vaporization: 61.14 kJ/mol
Boiling Point: 365.1 °C at 760 mmHg
Vapour Pressure: 1.6E-05 mmHg at 25 °C
Melting point: 242-244 °C
Product Categories: pharmacetical; PiperazineDerivative; Piperazine derivates; API intermediates; Aromatics Compounds; Aromatics; Intermediates & Fine Chemicals; Pharmaceuticals; Aripiprazole; piperazines
Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
Hazard Note: Irritant
1-(2,3-Dichlorophenyl)-piperazine hydrochloride , with CAS number of 41202-77-1, can be called 1-(2,3-Dichlorophenyl)piperazine hydrochloride (1:1) ; 1-(2,3-Dichlorphenyl)piperazinhydrochlorid ; piperazine, 1-(2,3-dichlorophenyl)-, hydrochloride (1:1) ; 1-(2,3-Dichlorophenyl)-Piperazine HCl . It is a kind of brown oil.