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CAS No.: | 41274-09-3 |
---|---|
Name: | (R)-Glycerol 1-(p-toluenesulfonate) |
Article Data: | 24 |
Molecular Structure: | |
Formula: | C10H14O5S |
Molecular Weight: | 246.284 |
Synonyms: | 1,2,3-Propanetriol,1-(4-methylbenzenesulfonate), (R)-;(R)-1,2,3-Propanetriol4-methylbenzenesulfonate;(R)-1-(Tosyloxy)-2,3-propanediol;(R)-1-Tosyloxyglycerol;(R)-3-(Tosyloxy)-1,2-propanediol;D-3-Tosylglycerol; |
Density: | 1.351 g/cm3 |
Melting Point: | 54-59 °C |
Boiling Point: | 463 °C at 760 mmHg |
Flash Point: | 233.8 °C |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 26-36 |
PSA: | 92.21000 |
LogP: | 1.13430 |
(R)-2,2-dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate
(R)-3-tosyloxy-1,2-propanediol
Conditions | Yield |
---|---|
With hydrogenchloride In acetone Heating; | 98% |
With hydrogenchloride In methanol at 20℃; for 0.5h; | 98% |
With Dowex 50X8 H(+) form In methanol at 60℃; for 7h; | 96% |
(R)-(-)-3-tosyloxy-2-benzyloxy-1-propanol
(R)-3-tosyloxy-1,2-propanediol
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In ethanol | 98% |
((R)-2,2-cyclohexylidine-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulphonate
(R)-3-tosyloxy-1,2-propanediol
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In methanol at 20℃; for 24h; | 85% |
(R)-(+)-3-tosyloxypropane-1,2-diol dipropionate
A
(R)-3-tosyloxy-1,2-propanediol
B
(S)-1-tosyloxy-2,3-propanediol
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In methanol at 60℃; for 3h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
allyl tosylate
A
(R)-3-tosyloxy-1,2-propanediol
B
(S)-1-tosyloxy-2,3-propanediol
Conditions | Yield |
---|---|
With potassium dioxotetrahydroxoosmate(VI); potassium carbonate; potassium hexacyanoferrate(III); 1,4-bis(dihydroquinidinyl)anthraquinone In water; tert-butyl alcohol at 0℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
(R)-3-tosyloxy-1,2-propanediol
Conditions | Yield |
---|---|
With hydrogenchloride |
p-toluenesulfonyl chloride
(R)-3-tosyloxy-1,2-propanediol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 68 percent / pyridine / 16 h / 0 - 28 °C 2: 95 percent / 1N HCl / acetone / 0.5 h / Heating View Scheme |
p-toluenesulfonyl chloride
(R)-3-tosyloxy-1,2-propanediol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: pyridine / 5 h / 20 °C 2: 3.166 g / TFA / H2O / 0.25 h / 20 °C View Scheme |
p-toluenesulfonyl chloride
(R)-3-tosyloxy-1,2-propanediol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / Ambient temperature 2: 1 M HCl / acetone / 90 - 95 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 91 percent / pyridine 2: 98 percent / HCl / acetone / Heating View Scheme |
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The CAS register number of (R)-Glycerol 1-(p-toluenesulfonate) is 41274-09-3. It also can be called as (R)-1-Tosyloxy-2,3-propanediol and the systematic name about this chemical is (2R)-2,3-dihydroxypropyl 4-methylbenzenesulfonate. The molecular formula about this chemical is C10H14O5S and molecular weight is 246.28. It belongs to the following product categories, such as Chiral; Chiral Reagents and so on.
Physical properties about (R)-Glycerol 1-(p-toluenesulfonate) are: (1)ACD/LogP: 0.05; (2)ACD/LogD (pH 5.5): 0.05; (3)ACD/LogD (pH 7.4): 0.05; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 25.36; (7)ACD/KOC (pH 7.4): 25.36; (8)#H bond acceptors: 5; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 7; (11)Polar Surface Area: 70.21Å2; (12)Index of Refraction: 1.559; (13)Molar Refractivity: 58.87 cm3; (14)Molar Volume: 182.2 cm3; (15)Polarizability: 23.33x10-24cm3; (16)Surface Tension: 54 dyne/cm; (17)Enthalpy of Vaporization: 76.3 kJ/mol; (18)Boiling Point: 463 °C at 760 mmHg; (19)Vapour Pressure: 2.27E-09 mmHg at 25°C.
When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)SMILES: O=S(=O)(OC[C@H](O)CO)c1ccc(cc1)C
(2)InChI: InChI=1/C10H14O5S/c1-8-2-4-10(5-3-8)16(13,14)15-7-9(12)6-11/h2-5,9,11-12H,6-7H2,1H3/t9-/m1/s1
(3)InChIKey: DFQNMODTAFTGHS-SECBINFHBY
(4)Std. InChI: InChI=1S/C10H14O5S/c1-8-2-4-10(5-3-8)16(13,14)15-7-9(12)6-11/h2-5,9,11-12H,6-7H2,1H3/t9-/m1/s1
(5)Std. InChIKey: DFQNMODTAFTGHS-SECBINFHSA-N