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4205-90-7

Basic Information
CAS No.: 4205-90-7
Name: CLONIDINE (200 MG)
Article Data: 29
Molecular Structure:
Molecular Structure of 4205-90-7 (CLONIDINE (200 MG))
Formula: C9H9 Cl2 N3
Molecular Weight: 230.097
Synonyms: 2-Imidazoline,2-(2,6-dichloroanilino)- (7CI,8CI); 2-(2,6-Dichloroanilino)-2-imidazoline;2-(2,6-Dichlorophenylimino)imidazolidine; 734571A; Catapres-TTS; Catapress;Catapressan; Clonidin; Clonidine; M 5041T; SKF 34427; ST 155BS
Density: 1.5g/cm3
Melting Point: 141-142℃
Boiling Point: 319.3°Cat760mmHg
Flash Point: 146.9°C
Hazard Symbols: F,T
Risk Codes: 11-23/24/25-39/23/24/25
Safety: Poison by ingestion and subcutaneous routes. Human systemic effects by ingestion: blood pressure lowering. An experimental teratogen. Other experimental reproductive effects. A skin irritant. When heated to decomposition it emits toxic fumes of NOx and Cl.
PSA: 36.42000
LogP: 2.20190
Downstream Products
33178-86-8
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Chemistry

Product Name: 2,6-Dichlor-N-imidazolidin-2-ylidenanilinhydrochlorid
The MF of 2,6-Dichlor-N-imidazolidin-2-ylidenanilinhydrochlorid (CAS NO.4205-90-7) is C9H10Cl3N3.

                                                
The MW of 2,6-Dichlor-N-imidazolidin-2-ylidenanilinhydrochlorid (CAS NO.4205-90-7) is 266.5548.
Synonyms of 2,6-Dichlor-N-imidazolidin-2-ylidenanilinhydrochlorid (CAS NO.4205-90-7): 2,6-Dichloro-N-2-imidazolidinylidenebenzenamine monohydrochloride ; 2,6-Dichloro-N-imidazolidin-2-ylidèneaniline chlorhydrate ; Benzenamine, 2,6-dichloro-N-2-imidazolidinylidene-, hydrochloride (1:1) ; Dichloranilino Imidazolin ; Ipotensium
Apperance: A white crystalline powder
EINECS: 224-119-4
Flash Point: 146.9 °C
Boiling Point: 319.3 °C 
Melting Point: 130 °C

Uses

  2,6-Dichlor-N-imidazolidin-2-ylidenanilinhydrochlorid (CAS NO.4205-90-7) is the central antihypertensive drugs for the treatment of moderate hypertension.

Production

Raw materials: 2,6-Dichloroaniline-->Clonidine Hydrochloride Chloride

Toxicity Data With Reference

1.    

skn-rbt 500 mg MLD

    OYYAA2    Oyo Yakuri. Pharmacometrics. 45 (1993),257.
2.    

orl-man TDLo:2857 ng/kg:BPR

    AIMDAP    Archives of Internal Medicine. 143 (1983),2195.
3.    

orl-rat LD50:157 mg/kg

    IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),366.
4.    

scu-rat LD50:108 mg/kg

    IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),366.
5.    

orl-mus LD50:108 mg/kg

    IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),366.
6.    

scu-mus LD50:364 mg/kg

    IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),366.

Safety Profile

Poison by ingestion and subcutaneous routes. Human systemic effects by ingestion: blood pressure lowering. An experimental teratogen. Other experimental reproductive effects. A skin irritant. When heated to decomposition it emits toxic fumes of NOx and Cl.