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Basic Information
CAS No.: 434-07-1
Name: Oxymetholone
Molecular Structure:
Molecular Structure of 434-07-1 (Oxymetholone)
Formula: C21H32O3
Molecular Weight: 332.483
Synonyms: 5a-Androstan-3-one,17b-hydroxy-2-(hydroxymethylene)-17-methyl- (6CI,8CI);17-Beta-Hydroxy-2-hydroxymethylene-17-alpha-methyl-3-androstanone;17a-Methyl-2-hydroxymethylene-17-hydroxy-5a-androstan-3-one;17b-Hydroxy-2-(hydroxymethylene)-17a-methyl-5a-androstan-3-one;2-Hydroxymethylene-17a-methyl-17b-hydroxy-3-androstanone;2-Hydroxymethylene-17a-methylandrostan-17b-ol-3-one;2-Hydroxymethylene-17b-hydroxy-17a-methyl-5a-androstan-3-one;Adroyd;Anadrol;Anapolan 50;Anapolon;Anasteron;Anasteronal;Anasterone;Becorel;C.I. 406;HMD;NSC-26198;Nastenon;Oxymethenolone;Pardroyd;Plenastril;Protanabol;Roboral;Synasteron;Synasteron 50;fiberdrum or foil bag;Androstan-3-one,17-hydroxy-2-(hydroxymethylene)-17-methyl-, (5a,17b)-;
EINECS: 207-098-6
Density: 1.169 g/cm3
Melting Point: 172-180 °C
Boiling Point: 465.9 °C at 760 mmHg
Flash Point: 249.7 °C
Solubility: <0.1 g/100 mL at 23 °C
Appearance: white crystalline powder
Hazard Symbols: ToxicT, HarmfulXn
Risk Codes: 40-63
Safety: 53-22-26-36/37/39-36
PSA: 57.53000
LogP: 4.40100
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Oxymetholone(434-07-1) is a synthetic anabolic steroid developed by Zoltan 'Anadrol Z' F in 1960.


1. Introduction of Oxymetholone
Oxymetholone is one kind of white crystalline powder. The IUPAC name of Oxymetholone is (2Z,5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-2-(hydroxymethylidene)-10,13,17-trimethyl-1,4,5,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one. The product's categories are pharmaceutical; biochemistry; hydroxyketosteroids; steroids. Additionally, Oxymetholone may be light sensitive, combustible and incompatible with strong oxidizing agents. Furthermore, it is a synthetic anabolic steroid developed in 1960 by Syntex Pharmaceuticals. 

The Classification Code of this chemical is Anabolic Agents; Androgen; Androgens; Drug / Therapeutic Agent; Hormone; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Human Data; Mutation data; Reproductive Effect; Tumor data. It is odorless white crystalline powder which is insoluble in water, easily soluble in chloroform, soluble in dioxane, vegetable oil, and slightly soluble in ethanol and ether.

2. Properties of Oxymetholone
Physical properties about Oxymetholone are:
(1)ACD/LogP: 4.22; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.17; (4)ACD/LogD (pH 7.4): 1.41; (5)ACD/BCF (pH 5.5): 85.45; (6)ACD/BCF (pH 7.4): 1.47; (7)ACD/KOC (pH 5.5): 424.82; (8)ACD/KOC (pH 7.4): 7.33; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.589; (13)Molar Refractivity: 95.89 cm3; (14)Molar Volume: 284.2 cm3; (15)Polarizability: 38.01×10-24 cm3; (16)Surface Tension: 50.3 dyne/cm; (17)Enthalpy of Vaporization: 83.9 kJ/mol; (18)Vapour Pressure: 1.23E-10 mmHg at 25°C; (19)Tautomer Count: 5; (20)Exact Mass: 332.235145; (21)MonoIsotopic Mass: 332.235145; (22)Topological Polar Surface Area: 57.5; (23)Heavy Atom Count: 24.

3. Structure Descriptors of Oxymetholone
People can use the following data to convert to the molecule structure.
(1)SMILES: O=C4/C(=C\O)C[C@]1([C@@H](CC[C@@H]2[C@@H]1CC[C@]3([C@H]2CC[C@@]3(O)C)C)C4)C
(2)InChI: InChI=1/C21H32O3/c1-19-11-13(12-22)18(23)10-14(19)4-5-15-16(19)6-8-20(2)17(15)7-9-21(20,3)24/h12,14-17,22,24H,4-11H2,1-3H3/b13-12-/t14-,15+,16-,17-,19-,20-,21-/m0/s1
(4)Canonical SMILES: CC12CCC3C(C1CCC2(C)O)CCC4C3(CC(=CO)C(=O)C4)
(5)CIsomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C)O)CC[C@@H]4[C@@]3(C/C(=C/O)/C(=O)C4)C

4. Toxicity of Oxymetholone
The following are the toxicity data which has been tested.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 46mg/kg/14W-I (46mg/kg) LIVER: LIVER FUNCTION TESTS IMPAIRED JAMA, Journal of the American Medical Association. Vol. 240, Pg. 243, 1978.
rat LD50 intraperitoneal > 1gm/kg (1000mg/kg)   Drugs in Japan Vol. 6, Pg. 156, 1982.

5. Production of Oxymetholone
Preparation of Oxymetholone: It can be obtained by hecogenin or tigogenin through acetylation, reduction, ring opening, oxidation, hydrolysis, elimination, oxime, rearrangement, hydrolysis, addition reaction, oxidation, hydrolysis, condensation and other multi-step reaction.

6. Safety information of Oxymetholone
Hazard Codes: TT, XnXn
Risk Statements: 40-63
Safety Statements: 53-22-26-36/37/39-36
WGK Germany: 3
RTECS: BV8060000

When you are using this chemical, please be cautious about it as the following:
It has limited evidence of a carcinogenic effect, but it is possible risk of harm to the unborn child. So people should not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection.

7. Uses of Oxymetholone
This drug was approved for human use by the FDA. It is mainly used in the treatment of osteoporosis and anaemia, as well as stimulating muscle growth in undernourished or underdeveloped patients. In addition, this drug is often used by bodybuilders and athletes, because it is highly effective in promoting extensive gains in body mass, mostly by greatly improving protein synthesis. Many athletes also use oxymetholone as a method of protection for the joints under heavy loads.