CAS No.446-86-6,Azathioprine Suppliers,MSDS download

Products Categories

Pharmaceutical (171)
Others (47)
Organic Chemicals (31)
Reagent (7)
Plant Extract (4)
Materials (2)

Basic Information

Molecular Structure:
CAS No.:	446-86-6
Name:	Azathioprine
Article Data:	6

Formula:	C₉H₇N₇O₂S
Molecular Weight:	277.266
Synonyms:	1H-Purine,6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]- (9CI);Purine,6-[(1-methyl-4-nitroimidazol-5-yl)thio]- (6CI,8CI);6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine;6-(1-Methyl-4-nitromidazol-5-ylthio)purine;Azamune;Azanin;Azathioprin;Azoran;BW 57-322;Imuran;Imurek;Imurel;Muran;NSC 39084;
EINECS:	207-175-4
Density:	1.9 g/cm³
Melting Point:	243-244 °C
Boiling Point:	685.7 °C at 760 mmHg
Flash Point:	368.5 °C
Solubility:	<0.1 g/100 mL at 23 °C in water
Appearance:	Yellow solid
Hazard Symbols:	Xn, T, Xi
Risk Codes:	45-22-36/37/38-20/21/22
Safety:	53-22-26-36/37-45-36
PSA:	143.40000
LogP:	1.66900

Downstream Products

3324-79-6

Total:192 Page 1 of 6 1 2 3 4 5 6 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 446-86-6

Chemistry

Product Name: Azathioprine (CAS NO.446-86-6)
Molecular Formula: C₉H₇N₇SO₂

Molecular Weight: 277.26
EINECS: 207-175-4
Melting point: 243-244°C
Storage temp.: Freezer
Water Solubility: <0.1 g/100 mL at 23 °C
Merck: 902
Index of Refraction: 1.923
Molar Refractivity: 68.88 cm³
Surface Tension: 98.3 dyne/cm
Density: 1.9 g/cm³
Flash Point: 368.5 °C
Enthalpy of Vaporization: 96.93 kJ/mol
Boiling Point: 685.7 °C at 760 mmHg
Vapour Pressure: 7.1E-18 mmHg at 25°C
Structure Descriptors of Product Name: Azathioprine (CAS NO.446-86-6):
IUPAC Name: 6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine
Canonical SMILES: CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-]
InChI: InChI=1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13)
InChIKey: LMEKQMALGUDUQG-

Uses

Azathioprine (CAS NO.446-86-6) is an immunosuppressant which is commonly used in organ transplantation, autoimmune disease or Inflammatory Bowel Disease (IBD). It is also used in multiple sclerosis, autoimmune hepatitis and restrictive lung disease. It's also active as disease modifying antirheumatic drug (DMARD).

Toxicity Data With Reference

1.	mma-sat 300 µmol/L	EXPEAM Experientia. 40 (1984),370.
2.	cyt-hmn-unr 1074 mg/kg/4Y	MUREAV Mutation Research. 94 (1982),501.
3.	orl-wmn TDLo:273 mg/kg/13 W-C:CAR,BLD	BMJOAE British Medical Journal. 4 (1972),235.
4.	orl-wmn TD:3 g/kg/3.5Y-C:CAR,KID	JAMAAP JAMA, Journal of the American Medical Association. 237 (1977),152.
5.	orl-wmn TD:5460 mg/kg/6Y-I:CAR,BLD	AMSVAZ Acta Medica Scandinavica. 207 (1980),315.
6.	orl-man TD:728 mg/kg/43 W-C:CAR,BLD	AJMSA9 American Journal of the Medical Sciences. 273 (1977),335.
7.	orl-man TD:1565 mg/kg/4Y-C:CAR,BLD	AJMEAZ American Journal of Medicine. 57 (1974),885.
8.	orl-man TD:3266 mg/kg/3Y-C:CAR,BLD	AJMEAZ American Journal of Medicine. 57 (1974),885.
9.	orl-wmn TD:2 g/kg/3Y-C:CAR,BLD	PGMJAO Postgraduate Medical Journal. 53 (1977),173.
10.	orl-man LDLo:395 mg/kg/56 W-I:SYS	GASTAB Gastroenterology. 90 (1986),446.
11.

RTECS: UO8925000

Consensus Reports

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 1 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 119.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 (1981),p. 47.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 (1981),p. 47.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Studies (ipr); No Evidence: rat CANCAR Cancer. 40 (1977),1935. ; Clear Evidence: mouse CANCAR Cancer. 40 (1977),1935. . EPA Genetic Toxicology Program.

Safety Profile

Confirmed human carcinogen producing bladder tumors and leukemia. Poison by subcutaneous, intradermal, and intraperitoneal routes. Moderately toxic by ingestion. Human systemic effects: liver changes, hypermotility, diarrhea, nausea or vomiting, increased body temperature, BP lowering, decreased urine volume or anuria, normocytic anemia, bone marrow changes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NO_x and SO_x. An immunosuppressant.

Hazard Codes: Xi Irritant ,T Toxic ,Xn Harmful
Risk Statements: 45-22-36/37/38-20/21/22
R45:May cause cancer.
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 53-22-26-36/37-45-36
S53:Avoid exposure - obtain special instructions before use.
S22:Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36:Wear suitable protective clothing.
Hazard Note: Irritant

Specification

Azathioprine (CAS NO.446-86-6) is also named as 6-((1-Methyl-4-nitro-1h-imidazol-5-yl)thio)-1h-purin ; 6-((1-Methyl-4-nitroimidazol-5-yl)thio)-purin ; 6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine ; 6-(1-Methyl-4-nitro-5-imidazolythio)-9H-pur-ine ; 6-(1-Methyl-4-nitroimidazol-5-ylthio)purin ; 6-(1-Methyl-p-nitro-5-imidazolyl)-thiopurine ; Azamun and so on.