CAS No.4474-91-3,ANGIOTENSIN II, HUMAN Suppliers

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Basic Information

Molecular Structure:
CAS No.:	4474-91-3
Name:	ANGIOTENSIN II, HUMAN
Article Data:	5

Formula:	C₅₀H₇₁N₁₃O₁₂
Molecular Weight:	1046.19
Synonyms:	Angiotensin II, human (Octapeptide);Alanine,N-[1-[N-[N-[N-[N-(N2-L-a-aspartyl-L-arginyl)-L-valyl]-L-tyrosyl]-L-isoleucyl]-L-histidyl]-L-prolyl]-3-phenyl-,L- (6CI,7CI);
EINECS:	2017-001-1
Density:	1.43 g/cm³
Boiling Point:	809.08°C (rough estimate)
Solubility:	Soluble in Water (25 mg/ml), and 5% Acetic Acid (1 mg/ml).
PSA:	406.34000
LogP:	3.06950

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Chemistry

Molecular Structure:

Molecular Formula: C₅₀H₇₁N₁₃O₁₂
Molecular Weight: 1046.1786
IUPAC Name: (3S)-3-Amino-4-[[(2S)-5-(diaminomethylideneamino)-1-[[(2R)-1-[[(2S)-1-[[(3S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-hydroxy-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
Synonyms of Angiotensin II, human (CAS NO.4474-91-3): Angiotensin II, ile(5)- ; Angiotensin ii [INN:JAN] ; 5-Isoleucine-angiotensin II ; 5-L-Isoleucineangiotensin II ; Angiotensin II (human) ; Angiotensin II (mouse) ; Angiotensin ii ; Human angiotensin II ; Isoleucine5-angiotensin II ; L-Phenylalanine, N-(1-(N-(N-(N-(N-(N2-L-alpha-aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)- ; 5-L-Isoleucineangiotensin II ; Alanine, N-(1-(N-(N-(N-(N-(N2-L-alpha-aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-3-phenyl-, L- ; Angiotensin II, 5-L-isoleucine-
CAS NO: 4474-91-3
Classification Code: Reproductive Effect
Index of Refraction: 1.663
Molar Refractivity: 269.46 cm³
Molar Volume: 726.8 cm³
Surface Tension: 61.6 dyne/cm
Density: 1.43 g/cm³

Uses

Angiotensin II, human (CAS NO.4474-91-3) is used in biochemical and medical research ,it is blood pressure medicine. Used for post-traumatic or surgical shock, or spinal anesthesia-induced hypotension.

Production

Raw materials :Sodium bicarbonate-->Dicyclohexylcarbodiimide-->Citric acid monohydrate-->L-Histidine-->Phenprobamate-->Octanoic hydrazide-->Angiotensin
Cbz-Phe-tert-butyl and the corresponding protected amino acids monomers as raw materials, using solid-phase synthesis, then Angiotensin II, human (CAS NO.4474-91-3) is derived .

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	30800ug/kg (30.8mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 6079, 1990.
rat	LD50	intravenous	17400ug/kg (17.4mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 6079, 1990.

Safety Profile

A poison by intravenous route. Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NO_x.
WGK Germany of Angiotensin II, human (CAS NO.4474-91-3): 3

Specification

Adverse reactions and contraindications: sometimes can cause dizziness, headache, even induced angina pectoris. Overdose can cause bradycardia. Cardiac dysfunction with caution.