CAS No.453562-69-1,Motesanib Suppliers

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Basic Information

Molecular Structure:
CAS No.:	453562-69-1
Name:	Motesanib
Article Data:	3

Formula:	C₂₂H₂₃N₅O
Molecular Weight:	373.458
Synonyms:	AMG 706;N-(2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide;3-Pyridinecarboxamide,N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-;
Density:	1.251 g/cm³
Boiling Point:	517.258 °C at 760 mmHg
Flash Point:	266.628 °C
PSA:	78.94000
LogP:	4.32810

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Specification

1. Introduction of Motesanib
Motesanib is one kind of Antineoplastic Agent. The IUPAC Name of this chemical is N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide. Besides, the Systematic name about this chemical is N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide. In addition, its Classification Code about this chemica lare Angiogenic agent, Antiangiogenesis agent and Antineoplastic Agents. Motesanib Solubility is DMSO.

2. Properties of Motesanib
Physical properties about Motesanib are:
(1)ACD/LogP: 3.88; (2)ACD/LogD (pH 5.5): 4; (3)ACD/LogD (pH 7.4): 4; (4)ACD/BCF (pH 5.5): 457; (5)ACD/BCF (pH 7.4): 947; (6)ACD/KOC (pH 5.5): 2262; (7)ACD/KOC (pH 7.4): 4685; (8)#H bond acceptors: 6; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 4; (11)Polar Surface Area: 78.94Å²; (12)Index of Refraction: 1.669; (13)Molar Refractivity: 111.34 cm³; (14)Molar Volume: 298.448 cm³; (15)Polarizability: 44.139x10^-24cm³; (16)Surface Tension: 59.321 dyne/cm; (17)Enthalpy of Vaporization: 78.953 kJ/mol.

3. Structure Descriptors of Motesanib
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(c2cccnc2NCc1ccncc1)Nc3ccc4c(c3)NCC4(C)C
(2)InChI: InChI=1/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)
(3)InChIKey: RAHBGWKEPAQNFF-UHFFFAOYAA
(4)Std. InChI: InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)
(5)Std. InChIKey: RAHBGWKEPAQNFF-UHFFFAOYSA-N

4. Uses of Motesanib
Motesanib can be used as a c-KIT protein inhibitor and antineoplastic agent. It is an experimental drug candidate and can be used as an orally administered small molecule antagonist of VEGF receptors, platelet-derived growth factor receptors, and stem cell factor receptors. In addition, it can be used as the phosphate salt motesanib diphosphate.