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CAS No.: | 466-11-5 |
---|---|
Name: | dexamethasone 21-(sodium sulphate) |
Molecular Structure: | |
Formula: | C22H29FO8S•Na |
Molecular Weight: | 495.56 |
Density: | g/cm3 |
Boiling Point: | °Cat760mmHg |
Flash Point: | °C |
Safety: | Moderately toxic by intraperitoneal and subcutaneous routes. A steroid. When heated to decomposition it emits toxic fumes of F−, SOx, and Na2O. |
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Product Name: Dexamethasone sodium sulfate (CAS NO.466-11-5)
Molecular Formula: C22H28FNaO8S
Molecular Weight: 494.5061 g/mol
Mol File: 466-11-5.mol
Einecs: 207-374-6
H-Bond Donor: 2
H-Bond Acceptor: 9
Rotatable Bond Count: 4
Tautomer Count: 6
Topological Polar Surface Area: 141
Heavy Atom Count: 33
Formal Charge: 0
Complexity: 1040
Defined Atom StereoCenter Count: 8
Covalently-Bonded Unit Count: 2
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 1660mg/kg (1660mg/kg) | Drugs in Japan Vol. 6, Pg. 477, 1982. | |
mouse | LD50 | oral | > 7500mg/kg (7500mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES LIVER: OTHER CHANGES | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 6, 1974. |
mouse | LD50 | subcutaneous | 2020mg/kg (2020mg/kg) | Drugs in Japan Vol. 6, Pg. 477, 1982. | |
rat | LD50 | intramuscular | > 400mg/kg (400mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979. | |
rat | LD50 | intraperitoneal | 2180mg/kg (2180mg/kg) | Drugs in Japan Vol. 6, Pg. 477, 1982. | |
rat | LD50 | intravenous | 1gm/kg (1000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979. | |
rat | LD50 | oral | > 7500mg/kg (7500mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES LIVER: OTHER CHANGES | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 6, 1974. |
rat | LD50 | subcutaneous | 3450mg/kg (3450mg/kg) | Drugs in Japan Vol. 6, Pg. 477, 1982. |
Moderately toxic by intraperitoneal and subcutaneous routes. A steroid. When heated to decomposition it emits toxic fumes of F−, SOx, and Na2O.
Dexamethasone sodium sulfate ,its CAS NO. is 466-11-5,the synonyms is Dexamethasone 21-(sodium sulphate) ; 9-Fluoro-11β,17-dihydroxy-16α-methyl-21-sodiosulfooxypregna-1,4-diene-3,20-dione .