CAS No.4757-55-5,Dimetacrine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	4757-55-5
Name:	Dimetacrine

Formula:	C20H26 N2
Molecular Weight:	294.44
Synonyms:	Acridan,10-[3-(dimethylamino)propyl]-9,9-dimethyl- (7CI,8CI);10-[3-(Dimethylamino)propyl]-9,9-dimethylacridan; Dimetacrine; Dimetacrino;Dimetacrinum; Dimethacrin; Dimethacrine;N,N,9,9-Tetramethyl-10(9H)-acridinepropanamine; NSC 100297
Density:	1.015 g/cm3
Boiling Point:	406.4oC at 760mmHg
Flash Point:	180.4oC
Safety:	Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.
PSA:	6.48000
LogP:	4.48070

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- China (Mainland)(33)
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Chemistry

Molecule structure of Dimetacrine (CAS NO.4757-55-5) :

IUPAC Name: 3-(9,9-dimethylacridin-10-yl)-N,N-dimethylpropan-1-amine
Molecular Weight: 294.43384 g/mol
Molecular Formula: C₂₀H₂₆N₂
Density: 1.015 g/cm³
Boiling Point: 406.4 °C at 760 mmHg
Flash Point: 180.4 °C
Index of Refraction: 1.559
Molar Refractivity: 93.62 cm³
Molar Volume: 289.8 cm³
Polarizability: 37.11×10^-24 cm³
Surface Tension: 36.7 dyne/cm
Enthalpy of Vaporization: 65.81 kJ/mol
Vapour Pressure: 8.19E-07 mmHg at 25 °C
XLogP3: 5.4
H-Bond Acceptor: 2
Rotatable Bond Count: 4
Exact Mass: 294.209599
MonoIsotopic Mass: 294.209599
Topological Polar Surface Area: 6.5
Heavy Atom Count: 22
Complexity: 337
Canonical SMILES: CC1(C2=CC=CC=C2N(C3=CC=CC=C31)CCCN(C)C)C
InChI: InChI=1S/C20H26N2/c1-20(2)16-10-5-7-12-18(16)22(15-9-14-21(3)4)19-13-8-6-11-17(19)20/h5-8,10-13H,9,14-15H2,1-4H3
InChIKey: RYQOGSFEJBUZBX-UHFFFAOYSA-N

Uses

Dimetacrine (CAS NO.4757-55-5) is a tricyclic antidepressant (TCA) used in Europe and formerly in Japan for the treatment of depression. It has imipramine-like effects; though, in a double-blind clinical trial against imipramine, dimetacrine was found to have lower efficacy in comparison and produced more weight loss and abnormal liver tests. Little is known about the pharmacology of dimetacrine, but it can be inferred that it acts in a similar manner to other TCAs.

Toxicity Data With Reference

1.	orl-rat LD50:1850 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 6 (1975),530.
2.	ipr-rat LD50:181 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 6 (1975),530.
3.	scu-rat LD50:1076 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 6 (1975),530.
4.	orl-mus LD50:1293 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 6 (1975),530.
5.	ipr-mus LD50:206 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 6 (1975),530.
6.	scu-mus LD50:676 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 6 (1975),530.
7.	ivn-mus LD50:39,600 µg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 6 (1975),530.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.

Specification

Dimetacrine (CAS NO.4757-55-5) is also called Dimethacrine ; 10-(3-(Dimethylamino)propyl)-9,9-dimethylacridan ; 5-20-08-00134 (Beilstein Handbook Reference) ; 9,9-Dimethyl-10-(3-(dimethylamino)propyl)acridan ; 9,9-Dimethyl-10-(3-dimethylaminopropyl)-9,10-dihydroacridin [IUPAC] ; BRN 1349663 ; Dimetacrina ; Dimetacrina [DCIT] ; Dimetacrino ; Dimetacrino [INN-Spanish] ; Dimetacrinum ; Dimetacrinum [INN-Latin] ; Dimethacrin ; Dimethacrine ; N,N,9,9-Tetramethyl-10(9H)-acridinepropanamine ; NSC 100297 ; UNII-O341NY501N .