CAS No.481-29-8,Epiandrosterone Suppliers

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Basic Information

Molecular Structure:
CAS No.:	481-29-8
Name:	Epiandrosterone
Article Data:	144
Cas Database

Formula:	C₁₉H₃₀O₂
Molecular Weight:	290.446
Synonyms:	5a-Androstan-17-one, 3b-hydroxy- (8CI);3-Epiandrosterone;3b-Androsterone;3b-Hydroxy-17-oxo-5a-androstane;3b-Hydroxy-5a-androstan-17-one;3b-Hydroxy-5a-androstane-17-one;3b-Hydroxyandrostan-17-one;3b-Hydroxyetioallocholan-17-one;3b-OH-5a-Androstane-17-one;5a-Androstan-17-one-3b-ol;5a-Androstan-3b-ol-17-one;5a-Androstane-3b-ol-17-one;Androsterone, epi-;Androsterone, trans-;Isoandrosterone;NSC 93996;d-Epiandrosterone;epi-Androsterone;iso-Androsterone;trans-Androsterone;
EINECS:	207-563-3
Density:	1.085 g/cm³
Melting Point:	172-174 °C
Boiling Point:	413.1 °C at 760 mmHg
Flash Point:	176.4 °C
Solubility:	Practically insoluble in water
Appearance:	white to off-white crystalline powder
Safety:	22-24/25
PSA:	37.30000
LogP:	3.95910

Synthetic route

: 53-43-0
dehydroepiandrosterone

: 481-29-8
Epiandrosterone

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen In ethanol at 20℃; under 2068.65 Torr; Inert atmosphere;	100%
With palladium on activated charcoal; hydrogen In ethanol under 2068.65 Torr;	100%
With palladium 10% on activated carbon; hydrogen In ethanol at 40℃; under 2068.65 Torr; for 12h;	99%

: 5615-34-9, 5717-84-0, 5953-71-9, 85848-91-5, 6030-66-6
(3β,5α)-3-hydroxyandrostan-17-one oxime

: 481-29-8
Epiandrosterone

Conditions

Conditions	Yield
With hydrogen; boric acid; acetone; W-2 Raney-Ni In tetrahydrofuran; methanol; water at 25℃; for 24h;	100%

: 111237-01-5
(3S,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-3-((tetrahydrofuran-2-yl)oxy)hexadecahydro-17H-cyclopenta[a]phenanthren-17-one

: 481-29-8
Epiandrosterone

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In ethanol for 1h; Ambient temperature;	100%

: 1239-31-2
3β-acetoxy-5α-androstan-17-one

: 481-29-8
Epiandrosterone

Conditions

Conditions	Yield
With methanol; sodium hydroxide at 40℃; for 4h; Inert atmosphere;	97%
With potassium hydroxide In methanol Heating;	95%
With lipase from Candida cylindracea; octanol In various solvent(s) at 37℃; for 144h;	92%

: 94618-98-1
benzoyloxy-3β oxydo-17α(N) N-methylamino-17β (5α) androstane

: 481-29-8
Epiandrosterone

Conditions

Conditions	Yield
With potassium hydroxide; water In methanol for 1h; Ambient temperature;	96%

: C22H31NO3

: 481-29-8
Epiandrosterone

Conditions

Conditions	Yield
Stage #1: C22H31NO3 With sodium tetrahydroborate In methanol at -10℃; for 0.5h; Stage #2: With potassium hydroxide In methanol; water at 40℃; for 1h;	92%

: C26H42O4

: 481-29-8
Epiandrosterone

Conditions

Conditions	Yield
With CuCl2*H2O In ethanol for 2.5h; Hydrolysis; Heating;	90%

: 846-46-8
androstanedione

: 481-29-8
Epiandrosterone

Conditions

Conditions	Yield
With sodium dithionite; phase transfer catalyst; sodium hydrogencarbonate In toluene for 8h; Heating;	87%
With ethanol; nickel Hydrogenation;
With ethanol; sodium ethanolate; platinum Hydrogenation;

: 102698-33-9
racem. trans-5,6-Dimethoxy-1,3-cyclohexadien

A: 481-29-8
Epiandrosterone

: 102848-89-5, 107537-59-7, 109906-45-8, 149116-95-0
(+)-anti-7,syn-8-Dimethoxy-2-oxa-3-azabicyclo<2.2.2>oct-5-en

Conditions

Conditions	Yield
With 17α-chloro-17β-nitroso-3β-hydroxy-5α-androstane In methanol; chloroform at -18℃; for 240h;	A 76% B 87%

: 846-46-8
androstanedione

A: 481-29-8
Epiandrosterone

B: 53-41-8
cis-androsterone

Conditions

Conditions	Yield
With trimethylamine-borane; silica gel; iron(III) chloride In benzene for 2h; Ambient temperature;	A 60.2% B 20.9%
With trimethylamine-borane; silica gel; iron(III) chloride In benzene for 2h; Product distribution; Ambient temperature; various catalysts and times;	A 60.2% B 20.9%
With hydrogen; Nic In tetrahydrofuran; ethanol at 25℃; under 760 Torr; for 1.16667h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

Raw Materials

141-78-6

846-46-8

571-20-0

Downstream Products

640-87-9

521-11-9

571-20-0

53-41-8

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Specification

The IUPAC name of Epiandrosterone is (3S,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one. With the CAS registry number 481-29-8, it is also named as 3beta-Hydroxyetioallocholan-17-one. The product's categories are pharmaceutical intermediates; steroids; 17-ketosteroids; biochemistry; hydroxyketosteroids. It is white to off-white crystalline powder whih is used for steroid hormone drug. It was first isolated in 1931, by Adolf Friedrich Johann Butenandt and Kurt Tscherning. Additionally, Epiandrosterone should be sealed in the container that the container is placed in the cool and dry aera. Furthermore, people ahould not breathe dust and avoid contact with skin and eyes.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 3.75; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 2; (4)#H bond donors: 1; (5)#Freely Rotating Bonds: 1; (6)Index of Refraction: 1.536; (7)Molar Refractivity: 83.49 cm³; (8)Molar Volume: 267.6 cm³; (9)Polarizability: 33.1×10^-24cm³; (10)Surface Tension: 41.1 dyne/cm; (11)Enthalpy of Vaporization: 76.93 kJ/mol; (12)Vapour Pressure: 1.5E-08 mmHg at 25°C; (13)Tautomer Count: 2; (14)Exact Mass: 290.22458; (15)MonoIsotopic Mass: 290.22458; (16)Topological Polar Surface Area: 37.3; (17)Heavy Atom Count: 21; (18)Complexity: 459.

Preparation of Epiandrosterone: It can be converted from the natural steroids androstanediol via 17β-hydroxysteroid dehydrogenase or from androstanedione via 3β-hydroxysteroid dehydrogenase. And it is also naturally obtained by the enzyme 5-alpha reductase from the adrenal hormone dehydroepiandrosterone (DHEA).

People can use the following data to convert to the molecule structure.
1.SMILES:O=C2[C@]1(CC[C@H]3[C@H]([C@@H]1CC2)CC[C@H]4C[C@@H](O)CC[C@]34C)C
2. InChI:InChI=1/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13-,14-,15-,16-,18-,19-/m0/s1.