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CAS No.: | 4876-10-2 |
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Name: | 4-Bromomethyl-1,2-dihydroquinoline-2-one |
Article Data: | 136 |
Molecular Structure: | |
Formula: | C10H8BrNO |
Molecular Weight: | 238.084 |
Synonyms: | 2-Quinolinol,4-(bromomethyl)- (8CI);Carbostyril, 4-(bromomethyl)- (6CI,7CI);4-(Bromomethyl)carbostyril;4-(Bromomethyl)quinolin-2(1H)-one;NSC 108455;4-Bromomethyl-2(1H)-quinolinone; |
EINECS: | 679-473-6 |
Density: | 1.542 g/cm3 |
Melting Point: | 255-258 °C |
Boiling Point: | 391.8 °C at 760 mmHg |
Flash Point: | 190.8 °C |
Appearance: | White-like powder |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 26-36/37/39 |
PSA: | 33.12000 |
LogP: | 2.83530 |
Conditions | Yield |
---|---|
With phosphorus pentoxide at 83℃; for 13h; Solvent; Flow reactor; Large scale; | 95.08% |
With sulfuric acid at 40℃; for 1.5h; | 64% |
With sulfuric acid Heating; |
Conditions | Yield |
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With sulfuric acid; bromine In chloroform | |
Multi-step reaction with 2 steps 1: bromine; acetic acid 2: sulfuric acid / 4 h View Scheme | |
Multi-step reaction with 2 steps 1: bromine / chloroform 2: sulfuric acid / 4 h / 90 °C View Scheme | |
Multi-step reaction with 2 steps 1: bromine / chloroform / 2 h / Heating / reflux 2: sulfuric acid / 1.5 h / 40 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: pyridine / xylene / 0.5 h / Heating / reflux 1.2: 3.07 h / Heating / reflux 2.1: bromine / chloroform / 2 h / Heating / reflux 3.1: sulfuric acid / 1.5 h / 40 °C View Scheme |
4-bromomethyl-2(1H)-quinolinone
2-acetylaminomalonic acid diethyl ester
2-acetylamino-2-(ethoxycarbonyl)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionic acid ethyl ester
Conditions | Yield |
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With sodium ethanolate; tetra-(n-butyl)ammonium iodide In ethanol at 60℃; for 8h; Reagent/catalyst; Temperature; | 98.44% |
With sodium In ethanol for 2h; | 69% |
With sodium hydroxide In water; dimethyl sulfoxide at 20 - 30℃; for 2h; Reagent/catalyst; Solvent; Large scale; |
4-bromomethyl-2(1H)-quinolinone
N-(pyridin-4-yl)furan-2-carboxamide
N-[(2-Oxo-1,2-dihydroquinolin-4-yl)methyl]-N-pyridin-4-yl-2-furamide
Conditions | Yield |
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With sodium hydride In N,N-dimethyl-formamide at 40℃; for 2h; | 95% |
4-bromomethyl-2(1H)-quinolinone
Conditions | Yield |
---|---|
With ammonia In isopropyl alcohol at 60℃; for 4h; | 95% |
Conditions | Yield |
---|---|
With tetraethylammonium perchlorate; triethylamine In ethanol; dimethyl sulfoxide at 20℃; for 4h; Electrolysis; Green chemistry; | 95% |
4-bromomethyl-2(1H)-quinolinone
allyl alcohol
4-[(allyloxy)methyl]quinol-2(1H)-one
Conditions | Yield |
---|---|
Stage #1: allyl alcohol With sodium hydride In tetrahydrofuran at 0℃; for 4h; Reflux; Stage #2: 4-bromomethyl-2(1H)-quinolinone In tetrahydrofuran at 0 - 20℃; for 6h; | 91% |
Conditions | Yield |
---|---|
With triethylamine In toluene at 70 - 80℃; for 5h; Solvent; Temperature; | 90% |
4-bromomethyl-2(1H)-quinolinone
2-(2-propynylsulfanyl)-1H-1,3-benzimidazole
Conditions | Yield |
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With sodium azide; copper(II) sulfate; sodium L-ascorbate In water; N,N-dimethyl-formamide at 20℃; for 12h; | 89% |
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IUPAC Name: 4-(Bromomethyl)-1H-quinolin-2-one
Synonyms of 2(1H)-Quinolinone,4-(bromomethyl)- (CAS NO.4876-10-2): 4-Bromomethyl-2-quinolinol ; 4-(Bromomethyl)-2(1h)-quinolinone ; 4-Bromomethylquinolinone ; 4-Bromomethyl-1,2-dihydroquinolin-2-one ; 4-Bromomethyl Carbostyril ; 4-(Bromomethyl)-2-hydroxyquinoline
CAS NO: 4876-10-2
Molecular Formula of 2(1H)-Quinolinone,4-(bromomethyl)- (CAS NO.4876-10-2): C10H8BrNO
Molecular Weight: 238.0806
Molecular Structure:
Melting Point: 255-258 °C
H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 1
Polar Surface Area: 20.31 Å2
Index of Refraction: 1.616
Molar Refractivity: 53.93 cm3
Molar Volume: 154.3 cm3
Surface Tension: 46.3 dyne/cm
Density of 2(1H)-Quinolinone,4-(bromomethyl)- (CAS NO.4876-10-2): 1.542 g/cm3
Flash Point: 190.8 °C
Enthalpy of Vaporization: 64.15 kJ/mol
Boiling Point: 391.8 °C at 760 mmHg
Vapour Pressure: 2.4E-06 mmHg at 25°C
2(1H)-Quinolinone,4-(bromomethyl)- (CAS NO.4876-10-2) is used as pharmaceutical Intermediates and rebamipide intermediate R-2.
Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
Hazard Note: Irritant