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494-52-0

Basic Information
CAS No.: 494-52-0
Name: (-)-ANABASINE
Article Data: 22
Molecular Structure:
Molecular Structure of 494-52-0 ((-)-ANABASINE)
Formula: C10H14 N2
Molecular Weight: 162.235
Synonyms: Anabasine(8CI); Pyridine, 3-(2-piperidinyl)-, (S)-; (-)-2-(3'-Pyridyl)piperidine;(-)-Anabasine; (2S)-2-(Pyridin-3-yl)piperidine; (S)-(-)-Anabasine;(S)-Anabasine; Anabasin; NSC 87504; Neonicotine; Neonikotin
EINECS: 207-791-3
Density: 1.054
Melting Point: 9°C
Boiling Point: 271 °C at 760 mmHg
Flash Point: 93 ºC
Appearance: White fine crystalline powder
Hazard Symbols:
Risk Codes: R23/24/25   
Safety: Poison by ingestion, subcutaneous, and intravenous routes. Moderately toxic by skin contact. An experimental teratogen. Insecticide. Acute and subacute toxicity: increased salivation, vertigo, confusion, disturbed vision and hearing, photophobia, cold extremities, nausea, vomiting, diarrhea, syncope, colonic spasms. When heated to decomposition it emits toxic fumes of NOx.
Transport Information: 3140
PSA: 24.92000
LogP: 2.22500
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Chemistry

MF: C10H14N2
MW: 162.23
EINECS: 207-791-3
mp:  9°C
bp:  270-272°C
density:  1,0455 g/cm3
refractive index:  1.5430
Fp:  93°C
Merck:  14,619
BRN:  82637
CAS DataBase Reference: 494-52-0(CAS DataBase Reference)
NIST Chemistry Reference: 494-52-0(NIST)
The structure of ANABASINE is: 

         


 

Uses

1、Anabasine is a pyridine alkaloid found in the Tree Tobacco (Nicotiana glauca) plant, a close relative of the common tobacco plant (Nicotiana tabacum). It is similar to nicotine. Its principal (historical) industrial use is as an insecticide.
2、Anabasine is present in trace amounts in tobacco smoke, and can be used as an indicator of a person's exposure to tobacco smoke.

 

Toxicity Data With Reference

1、RTECS#: CAS# 494-52-0: BV4375000
2、LD50/LC50: RTECS: Not available. 
3、Carcinogenicity: L(-)-Anabasine - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
4、Other: The toxicological properties have not been fully investigated. Experimental teratogen. See actual entry in RTECS for complete information. 
   
      
   

 

    
   

 

    
   

 

    

Safety Profile

Hazard Codes:  T
Risk Statements: Very Toxic in contact with skin;Very Toxic if swallowed
Safety Statements: Wear suitable protective clothing;Wear suitable gloves
RIDADR:  3140
RTECS:  BV4375000
HazardClass:  6.1
PackingGroup:  I
Hazardous Substances Data: 494-52-0(Hazardous Substances Data)
Poison by ingestion, subcutaneous, and intravenous routes. Moderately toxic by skin contact. An experimental teratogen. Insecticide. Acute and subacute toxicity: increased salivation, vertigo, confusion, disturbed vision and hearing, photophobia, cold extremities, nausea, vomiting, diarrhea, syncope, colonic spasms. When heated to decomposition it emits toxic fumes of NOx.

Specification

1、Fire Fighting Measures 
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Combustible liquid. 
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. 
2、Handling and Storage 
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood. 
Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container.