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| CAS No.: | 50-13-5 |
|---|---|
| Name: | MEPERIDINE HYDROCHLORIDE |
| Article Data: | 1 |
| Molecular Structure: | |
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|
|
| Formula: | C15H21 N O2 . Cl H |
| Molecular Weight: | 283.798 |
| Synonyms: | 4-Piperidinecarboxylicacid, 1-methyl-4-phenyl-, ethyl ester, hydrochloride (9CI); Isonipecotic acid,1-methyl-4-phenyl-, ethyl ester, hydrochloride (8CI); (?à)-Pethidine hydrochloride; Algil;Alodan; Antiduol; Centralgin; Demerol hydrochloride; Dispadol; Dolantal;Dolantin; Dolaren; Dolargan; Dolcontral; Dolestine; Dolin; Dolosal; Dolsin;Ethyl 1-methyl-4-phenylpiperidine-4-carboxylate hydrochloride; Ethyl1-methyl-4-phenylpiperidyl-4-carboxylate hydrochloride; Lidol; Mefedina;Meperidine hydrochloride; Mialgin; N-Methyl-4-phenyl-4-carbethoxypiperidinehydrochloride; NIH 10522; Operidine; Petantin; Petantin hydrochloride;Pethidine hydrochloride; Pethidine monohydrochloride; Piridosal; S 140; Wy 554 |
| EINECS: | 200-013-3 |
| Density: | g/cm3 |
| Melting Point: | 186-189° |
| Boiling Point: | 328.9 °C at 760 mmHg |
| Flash Point: | 111.6 °C |
| Solubility: | Very soluble in water; soluble in ethanol (~750 g/l) TS; practically insoluble in ether R |
| Appearance: | white, crystalline powder; odourless. |
| Hazard Symbols: |
 T F
|
| Risk Codes: | 25-39/23/24/25-23/24/25-11 |
| Safety: | 26-36/37/39-45-36/37-16-7 |
| PSA: | 29.54000 |
| LogP: | 2.95300 |
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This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
Chemistry
Molecular structure of Demerol hydrochloride (CAS NO.50-13-5) is:
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Product Name: Demerol hydrochloride
CAS Registry Number: 50-13-5
IUPAC Name: Ethyl 1-methyl-4-phenylpiperidine-4-carboxylate hydrochloride
Molecular Weight: 283.79368 [g/mol]
Molecular Formula: C15H22ClNO2
H-Bond Donor: 1
H-Bond Acceptor: 3
Storage temp.: 2-8 °C
Flash Point: 111.6 °C
Enthalpy of Vaporization: 57.13 kJ/mol
Boiling Point: 328.9 °C at 760 mmHg
Vapour Pressure: 0.000184 mmHg at 25°C
Other Registry Number: 2793-00-2 ;55989-09-8
Related Registry Number: 57-42-1 (Parent)
Classification Code: Analgesic [narcotic] ;Drug / Therapeutic Agent ;Human Data ;Mutation data ;Reproductive Effect
Canonical SMILES: CCOC(=O)C1(CCN(CC1)C)C2=CC=CC=C2.Cl
InChI: InChI=1S/C15H21NO2.ClH/c1-3-18-14(17)15(9-11-16(2)12-10-15)13-7-5-4-6-8-13;/h4-8H,3,9-12H2,1-2H3;1H
InChIKey: WCNLCIJMFAJCPX-UHFFFAOYSA-N
Uses
Demerol hydrochloride (CAS NO.50-13-5) is a narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | subcutaneous | 100mg/kg (100mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: ANALGESIA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 147, 1951. |
| cat | LDLo | oral | 100mg/kg (100mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 147, 1951. |
| chicken | LD50 | intraperitoneal | 52mg/kg (52mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Toxicology and Applied Pharmacology. Vol. 2, Pg. 558, 1960. |
| chicken | LD50 | intravenous | 42mg/kg (42mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Toxicology and Applied Pharmacology. Vol. 2, Pg. 558, 1960. |
| dog | LD50 | intravenous | 68mg/kg (68mg/kg) | BEHAVIORAL: ANALGESIA | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964. |
| frog | LD50 | parenteral | 515mg/kg (515mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 147, 1951. | |
| guinea pig | LD50 | intramuscular | 111mg/kg (111mg/kg) | Canadian Anaesthetists' Society Journal. Vol. 5, Pg. 161, 1958. | |
| guinea pig | LDLo | subcutaneous | 100mg/kg (100mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
| mouse | LD50 | intraperitoneal | 104mg/kg (104mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Pharmaceutical Sciences. Vol. 63, Pg. 451, 1974. |
| mouse | LD50 | intravenous | 32mg/kg (32mg/kg) | Toxicology and Applied Pharmacology. Vol. 6, Pg. 334, 1964. | |
| mouse | LD50 | oral | 178mg/kg (178mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 164, 1978. | |
| mouse | LD50 | subcutaneous | 150mg/kg (150mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 164, 1978. | |
| rabbit | LD50 | intravenous | 20mg/kg (20mg/kg) | BEHAVIORAL: ANALGESIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 216, Pg. 48, 1952. |
| rabbit | LD50 | oral | 500mg/kg (500mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 147, 1951. | |
| rabbit | LDLo | subcutaneous | 200mg/kg (200mg/kg) | BEHAVIORAL: ANALGESIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 216, Pg. 48, 1952. |
| rat | LD50 | intraperitoneal | 65mg/kg (65mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT BEHAVIORAL: REGIDITY | Toxicology. Vol. 14, Pg. 217, 1979. |
| rat | LD50 | intravenous | 30mg/kg (30mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 115, Pg. 213, 1958. | |
| rat | LD50 | oral | 170mg/kg (170mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 147, 1951. | |
| rat | LD50 | subcutaneous | 175mg/kg (175mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 238, 1953. | |
| rat | LD50 | unreported | 280mg/kg (280mg/kg) | BEHAVIORAL: ANALGESIA | Pharmacological Research Communications. Vol. 5, Pg. 175, 1973. |
| women | TDLo | intramuscular | 13500ug/kg/3D (13.5mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | American Journal of Psychiatry. Vol. 144, Pg. 1062, 1987. |
| women | TDLo | intramuscular | 43mg/kg/2D-I (43mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Annals of Emergency Medicine. Vol. 14, Pg. 1007, 1985. |
Safety Profile
Safty information about Demerol hydrochloride (CAS NO.50-13-5) is:
Hazard Codes: 
T; 
F
Risk Statements: 25-39/23/24/25-23/24/25-11
R25 :Toxic if swallowed.
R39/23/24/25:Danger of very serious irreversible effects and toxic by inhalation, in contact with skin and if swallowed.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R11:Highly flammable.
Safety Statements: 26-36/37/39-45-36/37-16-7
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37:Wear suitable protective clothing and gloves.
S16:Keep away from sources of ignition.
S7:Keep container tightly closed.
RIDADR: 1544
RTECS: NS5950000
HazardClass: 6.1(b)
PackingGroup: III
Specification
Demerol hydrochloride , its cas register number is 50-13-5. It also can be called Ethyl 1-methyl-4-phenylisonipecotate hydrochloride ; Ethyl 1-methyl-4-phenylpiperidine-4-carboxylate hydrochloride ; Ethyl 1-methyl-4-phenylpiperidine-4-carboxylate,hydrochloride ; Ethyl 1-methyl-4-phenylpiperidyl-4-carboxylate hydrochloride ; Ethyl-1-methyl-4-phenylisonipecotate hydrochloride ; Isonipecaine hydrochloride ; Lidol ; Mefedina ; Mepadin ; Meperidine ; Meperidine HCl ; Meperidine hydrochloride ; Meperidine hydrochloride preservative free ; Meperitab ; Mephedine ; Mialgin ; N-Methyl-4-phenyl-4-carbethoxypiperidine hydrochloride ; 4-Piperidinecarboxylic acid, 1-methyl-4-phenyl-, ethyl ester, hydrochloride ; Isonipecotic acid, 1-methyl-4-phenyl-, ethyl ester, hydrochloride ; Pethidine hydrochloride .