CAS No.50-53-3,Chlorpromazine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	50-53-3
Name:	Chlorpromazine
Article Data:	36

Formula:	C17H19 Cl N2 S
Molecular Weight:	318.87
Synonyms:	Phenothiazine,2-chloro-10-[3-(dimethylamino)propyl]- (7CI,8CI);2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine; 2-Chloropromazine; 2601A;Aminazin; Aminazine; Ampliactil; Amplictil; BC 135; CPZ; Chlor-Promanyl;Chlordelazin; Chlorderazin; Chlorpromados; Chlorpromazine; Chlropromados;Contomin; Elmarin; Esmind; Fenactil; Fenaktyl; Fraction AB; HL 5746;Largactilothiazine; Largactyl; Megaphen; NSC 167745; NSC 226514; Noiafren;Novomazina; Phenactyl; Proma; Promactil; Promazil; Propaphenin; Prozil; RP4560; SKF 2601A; Sanopron; Sedatil; Thorazin; Thorazine; Wintermin
EINECS:	200-045-8
Density:	1.212g/cm³
Melting Point:	192 - 196 C (decomposes)
Boiling Point:	450.1°Cat760mmHg
Flash Point:	226°C
Solubility:	Soluble	white to off-white crystalline powder
Hazard Symbols:	6.1 (Packing Group: III) UN NO.
Transport Information:	25kgs
PSA:	31.78000
LogP:	4.95940

Synthetic route

: 1219602-20-6
C11H16ClIN2

: 6320-02-1
2-bromothiophenol

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With copper(l) iodide; potassium carbonate; L-proline In ethyl methyl ether at 90 - 110℃; Inert atmosphere;	78%

: 50-00-0
formaldehyd

: 2095-17-2
2-chloro-10-(3-aminopropyl)phenothiazine

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With formic acid In water at 80℃; for 8h; Eschweiler-Clark Amine Methylation; Microwave irradiation;	66%

: 31928-44-6
2-bromo-4-chloroiodobenzene

: 6320-02-1
2-bromothiophenol

: 109-55-7
1-amino-3-(dimethylamino)propane

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate In toluene at 60 - 160℃; for 2.33333h; Microwave irradiation;	50%

...Expand

: 92-39-7
2-chlorophenothiazine

: 109-54-6
3-(Dimethylamino)propyl chloride

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With sodium amide
(i) NaNH2, toluene, (ii) /BRN= 605294/; Multistep reaction;
With potassium hydroxide; potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate toluene 1.) room temp., 2 h, 2.) reflux, 18 h; Yield given. Multistep reaction;

: 3179-63-3
3-Dimethylamino-1-propanol

: 36798-98-8
2-chloro-phenothiazine-10-carbonyl chloride

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With toluene Erhitzen des Reaktionsprodukts unter vermindertem Druck auf 210-220grad;

: 4414-83-9
3-(2-chloro-10H-phenothiazin-10-yl)propanonitrile

A: 2095-17-2
2-chloro-10-(3-aminopropyl)phenothiazine

B: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With nickel; dimethyl amine; benzene at 110 - 116℃; under 58840.6 Torr; Hydrogenation;

: 109454-48-0
N'-[2-(2-bromo-phenylsulfanyl)-5-chloro-phenyl]-N,N-dimethyl-propanediyldiamine

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With copper; potassium carbonate; N,N-dimethyl-formamide

: 969-99-3
chlorpromazine sulfoxide

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With iron; acetic acid; xylene

: 41951-57-9
1-(2-chloro-phenothiazin-10-yl)-3-methanesulfonyloxy-propane

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With dimethyl amine

: 103278-35-9
bis-[3-(2-chloro-phenothiazin-10-yl)-propyl]-methyl-amine

A: 63615-79-2
10-Allyl-2-chlorophenothiazine

B: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With sodium hydroxide; methyl iodide

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Chemistry

MF: C₁₇H₁₉ClN₂S
MW: 318.86416
MS:
EINECS: 200-045-8
Product Categories:
Mol File: 50-53-3.mol
Surface Tension: 46.6 dyne/cm
Density: 1.212 g/cm3
Flash Point: 226 °C
Enthalpy of Vaporization: 70.89 kJ/mol
Boiling Point: 450.1 °C at 760 mmHg
Vapour Pressure: 2.72E-08 mmHg at 25°C

Uses

3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine(50-53-3) have good effect on have good effect on schizophrenia, severe depression and anxiety, hyperactive children, you can also use 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine(50-53-3) to relieve nausea, belching.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	subcutaneous	> 10mg/kg (10mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
cat	LDLo	oral	100mg/kg (100mg/kg)	behavioral: altered sleep time (including change in righting reflex) behavioral: regidity gastrointestinal: nausea or vomiting	Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 561, 1976.
child	LDLo	oral	37500ug/kg (37.5mg/kg)	behavioral: convulsions or effect on seizure threshold behavioral: coma	New England Journal of Medicine. Vol. 256, Pg. 527, 1957.
dog	LD50	intravenous	30mg/kg (30mg/kg)	ungs, thorax, or respiration: emphysema blood: hemorrhage lungs, thorax, or respiration: acute pulmona	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 118, Pg. 358, 1959.
dog	LD50	subcutaneous	> 20mg/kg (20mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
dog	LDLo	oral	250mg/kg (250mg/kg)	behavioral: altered sleep time (including change in righting reflex) behavioral: regidity gastrointestinal: nausea or vomiting	Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 561, 1976.
guinea pig	LD50	intraperitoneal	87mg/kg (87mg/kg)		Medicina Experimentalis. Vol. 8, Pg. 237, 1963.
guinea pig	LDLo	oral	250mg/kg (250mg/kg)	behavioral: altered sleep time (including change in righting reflex) behavioral: regidity gastrointestinal: nausea or vomiting	Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 561, 1976.
human	TDLo	oral	8570ug/kg/12D (8.57mg/kg)	behavioral: wakefulness behavioral: muscle weakness behavioral: tremor	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 93, 1972.
infant	TDLo	oral	20mg/kg (20mg/kg)	vascular: bp lowering not characterized in autonomic section behavioral: somnolence (general depressed activity)	American Journal of Diseases of Children. Vol. 130, Pg. 507, 1976.
mammal (species unspecified)	LD50	oral	500mg/kg (500mg/kg)	behavioral: anticonvulsant behavioral: alteration of classical conditioning	Journal of Medicinal Chemistry. Vol. 8, Pg. 836, 1965.
man	TDLo	oral	8900ug/kg (8.9mg/kg)	lungs, thorax, or respiration: dyspnea	American Journal of Emergency Medicine. Vol. 14, Pg. 467, 1996.
man	TDLo	oral	217mg/kg/19D (217mg/kg)	blood: agranulocytosis skin and appendages (skin): "dermatitis, allergic: after systemic exposure"	Journal of Clinical Psychiatry. Vol. 46, Pg. 341, 1985.
monkey	LD50	subcutaneous	> 5mg/kg (5mg/kg)	blood: agranulocytosis skin and appendages (skin): "dermatitis, allergic: after systemic exposure"	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
mouse	LC50	inhalation	209mg/m3/2H (209mg/m3)	behavioral: muscle weakness cardiac: pulse rate increase without fall in bp blood: leukopenia	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 10, Pg. 73, 1968.
mouse	LD50	intraperitoneal	14mg/kg (14mg/kg)		Farmaco, Edizione Scientifica. Vol. 14, Pg. 269, 1959.
mouse	LD50	intravenous	16mg/kg (16mg/kg)	behavioral: muscle weakness cardiac: pulse rate increase without fall in bp blood: leukopenia	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
mouse	LD50	oral	135mg/kg (135mg/kg)	lbehavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: other changes	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 118, Pg. 358, 1959.
mouse	LD50	subcutaneous	33mg/kg (33mg/kg)	behavioral: ataxia behavioral: regidity	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
mouse	LD50	unreported	82500ug/kg (82.5mg/kg)		Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 53, Pg. 2S, 1957.
mouse	LDLo	intramuscular	300mg/kg (300mg/kg)		Therapie. Vol. 15, Pg. 1064, 1960.
rabbit	LD50	intravenous	16mg/kg (16mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 450, 1959.
rat	LC50	inhalation	209mg/m3/2H (209mg/m3)	behavioral: muscle weakness cardiac: pulse rate increase without fall in bp blood: leukopenia	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 10, Pg. 73, 1968.
rat	LD50	intraperitoneal	137mg/kg (137mg/kg)		German Offenlegungsschrift Patent Document. Vol. #2350222,
rat	LD50	intravenous	23mg/kg (23mg/kg)	behavioral: muscle weakness cardiac: pulse rate increase without fall in bp blood: leukopenia	Farmaco, Edizione Pratica. Vol. 26, Pg. 585, 1971.
rat	LD50	oral	142mg/kg (142mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 261, 1968.
rat	LD50	subcutaneous	75mg/kg (75mg/kg)		Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 56, Pg. 377, 1960.
women	TDLo	oral	200ug/kg (0.2mg/kg)	behavioral: sleep liver: "jaundice, other or unclassified"	New York State Journal of Medicine. Vol. 57, Pg. 1922, 1957.
women	TDLo	oral	16800ug/kg/3W (16.8mg/kg)	blood: agranulocytosis	Postgraduate Medical Journal. Vol. 69, Pg. 885, 1993.
women	TDLo	oral	166mg/kg/18D- (166mg/kg)	blood: other hemolysis with or without anemia blood: other changes	Postgraduate Medical Journal. Vol. 53, Pg. 278, 1977.
women	TDLo	oral	240mg/kg/30D- (240mg/kg)	blood: agranulocytosis blood: changes in leucocyte (wbc) count blood: agranulocytosis	Journal of Clinical Psychiatry. Vol. 46, Pg. 341, 1985.
women	TDLo	oral	240mg/kg/30D (240mg/kg)	skin and appendages (skin): "dermatitis, allergic: after systemic exposure"	Journal of Clinical Psychiatry. Vol. 46, Pg. 341, 1985.

Specification

IUPAC: 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine(50-53-3)
CAS: 50-53-3
Synonyms: 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-;2601-A;2-Chloro-10-[3-(dimethyamino)propyl]phenothiazine;2-Chloropromazine;2-Cloro-10 (3-dimetilaminopropil)fenotiazina;3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine;4560 R.P.;Aminasine