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| CAS No.: | 500-92-5 |
|---|---|
| Name: | N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE |
| Article Data: | 21 |
| Molecular Structure: | |
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| Formula: | C11H16 Cl N5 |
| Molecular Weight: | 253.735 |
| Synonyms: | Biguanide,1-(p-chlorophenyl)-5-isopropyl- (8CI); 1-(p-Chlorophenyl)-5-isopropylbiguanide;1-Isopropyl-5-(4-chlorophenyl)biguanide; Bigumal; Chlorguanid; Chlorguanide;Chloroguanide; N1-p-Chlorophenyl-N5-isopropylbiguanide; Paludrin; Proguanil |
| Density: | 1.29g/cm3 |
| Melting Point: | 129° |
| Boiling Point: | 402.7°Cat760mmHg |
| Flash Point: | 197.4°C |
| Safety: | Poison by ingestion, intravenous, and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl− and NOx. |
| PSA: | 83.79000 |
| LogP: | 3.26330 |
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Chemistry
Systematic Name: 1-{Amino[(4-chlorophenyl)amino]methylidene}-2-propan-2-ylguanidine
Synonyms of 1-(p-Chlorophenyl)-5-isopropylbiguanide (CAS NO.500-92-5): 1-Isopropyl-5-(4-chlorophenyl)biguanide ; Bigumal ; Chlorguanid ; N1-p-Chlorophenyl-N5-isopropylbiguanide ; Proguanil ;Biguanide, 1-(p-chlorophenyl)-5-isopropyl- ; Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-
CAS NO:500-92-5
Molecular Formula:C11H16ClN5
Molecular Weight: 253.7312
Molecular Structure: .png)
EINECS: 207-915-6
Index of Refraction: 1.607
Surface Tension: 45.9 dyne/cm
Density: 1.29 g/cm3
Flash Point: 197.4 °C
Enthalpy of Vaporization: 65.39 kJ/mol
Boiling Point: 402.7 °C at 760 mmHg
Vapour Pressure: 1.07E-06 mmHg at 25°C
Uses
1-(p-Chlorophenyl)-5-isopropylbiguanide (CAS NO.500-92-5) is used as pharmaceutical intermediates.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| chicken | LDLo | intravenous | 60mg/kg (60mg/kg) | Compilation of LD50 Values of New Drugs. | |
| chicken | LDLo | oral | 400mg/kg (400mg/kg) | Compilation of LD50 Values of New Drugs. | |
| mouse | LD50 | intravenous | 22mg/kg (22mg/kg) | British Journal of Pharmacology and Chemotherapy. Vol. 4, Pg. 14, 1949. | |
| mouse | LDLo | intraperitoneal | 25mg/kg (25mg/kg) | Compilation of LD50 Values of New Drugs. | |
| mouse | LDLo | oral | 50mg/kg (50mg/kg) | Compilation of LD50 Values of New Drugs. | |
| rabbit | LD50 | intraperitoneal | 50mg/kg (50mg/kg) | Compilation of LD50 Values of New Drugs. | |
| rabbit | LD50 | oral | 150mg/kg (150mg/kg) | Compilation of LD50 Values of New Drugs. | |
| rat | LD50 | intraperitoneal | 15mg/kg (15mg/kg) | "International Congress of Chemotherapy, Proceedings of the 3rd Congress, 1963," Kuemmerle, H.P., and Prezios, P., Stuttgart, Fed. Rep. Ger., Georg Thieme Verlag, 1964Vol. -, Pg. 367, 1964. | |
| rat | LDLo | intravenous | 40mg/kg (40mg/kg) | Compilation of LD50 Values of New Drugs. |
Safety Profile
Poison by ingestion, intravenous, and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl− and NOx.