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| CAS No.: | 504-76-7 |
|---|---|
| Name: | 1,3-Oxazolidine |
| Molecular Structure: | |
|
|
|
| Formula: | C3H7 N O |
| Molecular Weight: | 73.0947 |
| Synonyms: | 1,3-Oxazacyclopentane;1,3-Oxazolidine; 1-Oxa-3-azacyclopentane; Oxazole, tetrahydro-;Tetrahydrooxazole |
| Density: | 0.964g/cm3 |
| Melting Point: | 90 °C(Solv: benzene (71-43-2)) |
| Boiling Point: | 99.2°Cat760mmHg |
| Flash Point: | 18.8°C |
| PSA: | 21.26000 |
| LogP: | -0.10750 |

| Conditions | Yield |
|---|---|
| Destillation unter vermindertem Druck; | |
| Heating; |

| Conditions | Yield |
|---|---|
| Destillation des erhaltenen 1,3,5-Tris-<2-hydroxy-aethyl>-hexahydro-<1,3,5>triazins unter vermindertem Druck; | |
| With 4 A molecular sieve In benzene at 40℃; for 2h; | 3.0 g |
| In benzene Heating; | |
| In benzene Heating; |

N-(2-chloroethyl)-N'-(4-methylthiophenyl)urea

A

1,3-oxazolidine

B

2-(4-methylthiophenylimino) oxazolidine

| Conditions | Yield |
|---|---|
| In water |

1,1-dimethylhydrazine

A

1,3-oxazolidine

B

N-Methylformamide

C

butanedial

D

N,N-Dimethylamino acetonitrile

E

N-methyl-N-(methyleneamino)methanamine

F

N-Nitrosodimethylamine

G

N-nitrodimethylamine

H

dimethyl amine

| Conditions | Yield |
|---|---|
| With α-manganese oxide; water at 0℃; Reagent/catalyst; UV-irradiation; Flow reactor; |


1,3-oxazolidine


tributylphosphine


ethyl cyanoformate


4-ethoxycarbonyl-5-phenyl-2-trifluoromethyl imidazole

| Conditions | Yield |
|---|---|
| In toluene | 84% |


1,3-oxazolidine


1-bromo-2-(triisopropylsilyl)acetylene

| Conditions | Yield |
|---|---|
| With potassium phosphate; copper(l) iodide; N,N-dimethylethylenediamine In toluene at 110℃; for 15h; Inert atmosphere; | 78% |

| Conditions | Yield |
|---|---|
| In benzene Heating; | 65% |


| Conditions | Yield |
|---|---|
| In benzene Heating; | 63% |
| In benzene Heating; | 47.9 g |

azetidine


1,3-oxazolidine


(S)-N-(4-chloro-2-(2-(5,7-dichloropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide


C25H30ClN7O4S

| Conditions | Yield |
|---|---|
| Stage #1: 1,3-oxazolidine; (S)-N-(4-chloro-2-(2-(5,7-dichloropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 70℃; for 2h; Stage #2: azetidine In tetrahydrofuran at 70℃; for 2h; | 62% |


| Conditions | Yield |
|---|---|
| With triethylamine In benzene at 0 - 20℃; | 50% |