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| CAS No.: | 5086-74-8 |
|---|---|
| Name: | Tetramisole hydrochloride |
| Article Data: | 7 |
| Molecular Structure: | |
|
|
|
| Formula: | C11H12N2S.HCl |
| Molecular Weight: | 240.757 |
| Synonyms: | Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride (9CI);Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (?à)- (8CI);2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride;Anthelvet;Citarin;Concurat;Curaminth;DL-Tetramisole hydrochloride;McN JR8299;NSC 170985;NSC 215179;Nilverm;Nilverom;R 8299;Ripercol;Verminject; |
| EINECS: | 225-799-5 |
| Melting Point: | 266-267 °C(lit.) |
| Boiling Point: | 344.4 °C at 760 mmHg |
| Flash Point: | 162.1 °C |
| Solubility: | Water Solubility :200 g/L (20 °C) |
| Appearance: | white to pale cream crystalline powder |
| Hazard Symbols: |
 Xi, Xn
|
| Risk Codes: | 22-36/37/38-20/21/22 |
| Safety: | 26-36 |
| PSA: | 40.90000 |
| LogP: | 2.32160 |
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pyrographite
- 65329-73-9
1-(2-acetoxy-ethyl)-4-phenyl-imidazolidin-2-one
- 5086-74-8
tetramisole hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride; sodium hydroxide In ethanol; chloroform; toluene | |
| With hydrogenchloride; sodium hydroxide In ethanol; chloroform; toluene |
- 65329-69-3
1-(2-methoxy-ethyl)-4-phenyl-imidazolidin-2-one
- 5086-74-8
tetramisole hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride; sodium hydroxide In ethanol; chloroform; toluene |
- 65329-72-8
1-(2-hydroxy-ethyl)-4-phenyl-imidazolidin-2-one
- 5086-74-8
tetramisole hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride; sodium hydroxide In ethanol; chloroform; toluene | |
| With hydrogenchloride; sodium hydroxide In ethanol; chloroform; toluene |
- 65329-70-6
1-(2-methoxy-ethyl)-4-phenyl-imidazolidine-2-thione
- 5086-74-8
tetramisole hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride In ethanol; acetone | |
| With hydrogenchloride In ethanol; acetone |
- 65329-69-3
1-(2-methoxy-ethyl)-4-phenyl-imidazolidin-2-one
- 5086-74-8
tetramisole hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride; diphosphorus pentasulfide; sodium hydroxide In ethanol; chloroform; toluene | |
| Multi-step reaction with 2 steps 1: hydrogenchloride; sodium hydroxide / chloroform; acetone; toluene 2: hydrogenchloride / ethanol; acetone View Scheme |
- 69510-65-2
1-(2-hydroxy-ethyl)-4-phenyl-imidazolidine-2-thione
- 5086-74-8
tetramisole hydrochloride
| Conditions | Yield |
|---|---|
| In hydrogenchloride; isopropyl alcohol |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: acetic acid / methanol; dichloromethane; chloroform; water 2: palladium / ethanol; hydrogen 3: hydrogenchloride; diphosphorus pentasulfide; sodium hydroxide / ethanol; chloroform; toluene View Scheme | |
| Multi-step reaction with 4 steps 1: acetic acid / methanol; dichloromethane; chloroform; water 2: palladium / ethanol; hydrogen 3: hydrogenchloride; sodium hydroxide / chloroform; acetone; toluene 4: hydrogenchloride / ethanol; acetone View Scheme |
- 65346-98-7
1-(2-methoxy-ethyl)-4-phenyl-1,3-dihydro-imidazol-2-one
- 5086-74-8
tetramisole hydrochloride
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: palladium / ethanol; hydrogen 2: hydrogenchloride; diphosphorus pentasulfide; sodium hydroxide / ethanol; chloroform; toluene View Scheme | |
| Multi-step reaction with 3 steps 1: palladium / ethanol; hydrogen 2: hydrogenchloride; sodium hydroxide / chloroform; acetone; toluene 3: hydrogenchloride / ethanol; acetone View Scheme |
| Conditions | Yield |
|---|---|
| With sodium hydroxide In diethyl ether; water at 20℃; for 0.5h; Inert atmosphere; | 95% |
- 15243-33-1
dodecacarbonyl-triangulo-triruthenium
- 5086-74-8
tetramisole hydrochloride
| Conditions | Yield |
|---|---|
| In tetrahydrofuran all manipulations under N2; mixt. of Ru and org. compds. in THF stirred and refluxed for 40 min; cooled to room temp., filtered, filtrate concd., pptd. with hexane, elem. anal.; | 93% |
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Chemistry
IUPAC Name: 6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole hydrochloride
Product Category of Tetramisole hydrochloride (CAS NO.5086-74-8): API;Veterinaries
Molecular Formula: C11H13ClN2S
Molecular Weight: 240.75 g/mol
EINECS: 225-799-5
Flash Point: 162.1 °C
Melting point: 266-267 °C(lit.)
Water Solubility: 200 g/L (20 °C)
Enthalpy of Vaporization: 58.83 kJ/mol
Boiling Point: 344.4 °C at 760 mmHg
Vapour Pressure: 6.61E-05 mmHg at 25 °C
Appearance: White to pale cream crystalline powder
Structure of Tetramisole hydrochloride (CAS NO.5086-74-8):
Uses
Tetramisole hydrochloride (CAS NO.5086-74-8) can be used as intermediate of levamisole and anti-worm drugs.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| duck | LD50 | oral | 958mg/kg (958mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) | Veterinariya. Veterinary Science. Vol. 54(5), Pg. 64, 1978. |
| human | TDLo | oral | 2mg/kg (2mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Toxicology and Applied Pharmacology. Vol. 20, Pg. 602, 1971. |
| mouse | LD50 | intravenous | 22mg/kg (22mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Nature. Vol. 209, Pg. 1084, 1966. |
| mouse | LD50 | oral | 210mg/kg (210mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Nature. Vol. 209, Pg. 1084, 1966. |
| mouse | LD50 | subcutaneous | 84mg/kg (84mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Nature. Vol. 209, Pg. 1084, 1966. |
| rat | LD50 | intravenous | 24mg/kg (24mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Nature. Vol. 209, Pg. 1084, 1966. |
| rat | LD50 | oral | 480mg/kg (480mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Nature. Vol. 209, Pg. 1084, 1966. |
| rat | LD50 | subcutaneous | 130mg/kg (130mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Nature. Vol. 209, Pg. 1084, 1966. |
Tetramisole hydrochloride (CAS NO.5086-74-8) hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. And the toxicological properties have not been fully investigated. You can see actual entry in RTECS for complete information.
Safety Profile
Hazard Codes: Xn,Xi .gif){kind=small}
Risk Statements: 36/37/38-20/21/22
20/21/22: Tetramisole hydrochloride (5086-74-8) is harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
WGK Germany: 3
RTECS: NJ5950000
Specification
Tetramisole hydrochloride , its cas register number is 5086-74-8. It also can be called Levamisole hydrochloride ; DL-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride ; and Nilverm . It is stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: hydrogen chloride, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide. Its hazardous polymerization will not occur. In addition, it should be stored in a cool, dry place.
It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product : Wash mouth out with water, and get medical aid immediately. In addition, Tetramisole hydrochloride (CAS NO.5086-74-8) could be stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: hydrogen chloride, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.
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