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| CAS No.: | 509-67-1 |
|---|---|
| Name: | PHOLCODINE |
| Article Data: | 3 |
| Molecular Structure: | |
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| Formula: | C23H30 N2 O4 |
| Molecular Weight: | 398.502 |
| Synonyms: | Morphinan-6a-ol, 7,8-didehydro-4,5a-epoxy-17-methyl-3-(2-morpholinoethoxy)-(8CI); Morphine, 3-O-(2-morpholinoethyl)- (7CI); Morphine,O3-(2-morpholinoethyl)- (6CI); 3-[2-(4-Morpholinyl)ethyl]morphine; Biocalyptol;Codylin; Ethnine; Folcodin; Folcodine; Galenphol; Galphol; Glycodine; Hibernyl;Homocodeine; Memine; Morpholinylethylmorphine; Neocodine;O-2-Morpholinoethylmorphine; O3-(2-Morpholinoethyl)morphine; Pectolin;Pholcodine; Pholtex; Tussokon; Weifacodine; b-Morpholinylethylmorphine |
| Density: | 1.34g/cm3 |
| Melting Point: | 91°C |
| Boiling Point: | 577.8°Cat760mmHg |
| Flash Point: | 303.2°C |
| Safety: | Poison by intraperitoneal and intravenous routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx. Used as an antitussive agent. See also CODEINE. |
| PSA: | 54.40000 |
| LogP: | 1.07930 |
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This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
Chemistry
Product Name: Pholcodine
Synonyms: (5Alpha,6Alpha)-7,8-Didehydro-4,5-epoxy-17-methyl-3-[2-(4-morpholinyl)ethoxy]morphinan-6-ol ; 3-(2-(4-morpholinyl)ethyl)Morphine ; 3-(2-morpholinoethyl)Morphine ; 3-Morpholylaethylmorphin ; 3-O-(2-morpholinoethyl)-Morphin ; 7,8-Didehydro-4,5-alpha-epoxy-17-methyl-3-(2-morpholinoethoxy)morphinan-6-al ; 7,8-Didehydro-4,5-alpha-epoxy-17-methyl-3-(2-morpholinoethoxy)morphinan-6-alpha-ol ; Beta-morpholinoethylmorphine
CAS: 509-67-1
Molecular Formula: C23H30N2O4
Molecular Weight:398.5
Molecular Struture: 
EINECS: 208-102-9
Mol File: 509-67-1.mol
Surface Tension: 63.4 dyne/cm
Density: 1.34 g/cm3
Flash Point: 303.2 °C
Enthalpy of Vaporization: 90.97 kJ/mol
Boiling Point: 577.8 °C at 760 mmHg
Vapour Pressure: 3.44E-14 mmHg at 25°C
Index of Refraction: 1.659
Appearance: Tetrahydro-1,4-oxazinylmethylcodeine (509-67-1) is white or almost white, crystalline powder
Uses
Tetrahydro-1,4-oxazinylmethylcodeine (509-67-1) is used for severe dry cough and moderate degree of pain. Newborn and child are easy to tolerate the drug, without causing constipation and digestive disorders.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 400mg/kg (400mg/kg) | Therapie. Vol. 7, Pg. 21, 1952. | |
| mouse | LD50 | intravenous | 230mg/kg (230mg/kg) | Therapie. Vol. 7, Pg. 21, 1952. | |
| mouse | LD50 | oral | 1gm/kg (1000mg/kg) | Cesko-Slovenska Farmacie. Vol. 12, Pg. 89, 1963. | |
| mouse | LD50 | subcutaneous | 540mg/kg (540mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 325, 1958. |
| rabbit | LD50 | intravenous | 300mg/kg (300mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 325, 1958. |
Safety Profile
Poison by intraperitoneal and intravenous routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx. Used as an antitussive agent. See also CODEINE.
Specification
1.Properties: Tetrahydro-1,4-oxazinylmethylcodeine (509-67-1) is odorless, bitter taste; aqueous react alkaline . soluble in acetone or chloroform,, soluble in water and ether, dissolved in dilute hydrochloric acid.
2.Pharmacological effects: This product has a central antitussive effect similar to codeine phosphate, but also has sedative and analgesic effect, but it's addictive is weaker than codeine phosphate.
3.Consumption usage:Oral: 1 5 ~ 15mg, 1 3 times a day. Maximum dose: 60mg / d.