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CAS No.: | 51-45-6 |
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Name: | Histamine |
Article Data: | 64 |
Molecular Structure: | |
Formula: | C5H9N3 |
Molecular Weight: | 111.147 |
Synonyms: | 1H-Imidazole-4-ethanamine(9CI);Histamine (8CI);2-(1H-Imidazol-4-yl)ethanamine;2-(1H-Imidazol-5-yl)ethanamine;2-(3H-Imidazol-4-yl)ethylamine;2-(4-Imidazolyl)ethanamine;4-(2-Aminoethyl)imidazole;5-Imidazoleethylamine;Eramin;Ergamine;Ergotidine;Imidazole-4-ethylamine;NSC 33792;b-Imidazolyl-4-ethylamine; |
EINECS: | 200-100-6 |
Density: | 1.14 g/cm3 |
Melting Point: | 83-84 °C(lit.) |
Boiling Point: | 331 °C at 760 mmHg |
Flash Point: | 180.3 °C |
Solubility: | Soluble in water, alcohol, and hot chloroform. |
Appearance: | White to slightly yellow powder |
Hazard Symbols: | Xn |
Risk Codes: | 22-36/37/38-42/43 |
Safety: | 22-26-36/37 |
Transport Information: | UN 2811 6.1/PG 3 |
PSA: | 54.70000 |
LogP: | 0.61120 |
4-cyanomethylimidazole
histamine
Conditions | Yield |
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With hydrazine hydrate In ethanol at 60℃; for 1h; Autoclave; Industrial scale; | 66% |
With ammonia; nickel |
4-(2-chloroethyl)-1H-imidazole
histamine
Conditions | Yield |
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With ethanol; ammonia |
monocloridrato di 2-(2-tiono-4-imidazolin-4-il)etilamina
histamine
Conditions | Yield |
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With water; iron(III) chloride |
Conditions | Yield |
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bei der Zersetzung durch Bakterien der Coli-Typhus-Gruppe; | |
bei der Zersetzung durch Bakterien der Coli-Typhus-Gruppe in saurem Medium und bei Gegenwart von kohlenstoff- und stickstoffliefernden Substanzen; | |
Bakterielle Bildung bei der Faeulnis von Sojabohnen zurueckzufuehren; |
Conditions | Yield |
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With sulfuric acid at 240 - 250℃; |
Conditions | Yield |
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at 240℃; unter vermindertem Druck; Behandeln des Reaktionsprodukts mit konz. Salzsaeure bei 180gradC; | |
at 240℃; im Vakuum und Behandeln des Reaktionsprodukts mit konz.Salzsaeure bei 180grad; |
Conditions | Yield |
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Multistep reaction; |
Conditions | Yield |
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With hydrogenchloride at 100℃; for 24h; |
histamine
Conditions | Yield |
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With tri-n-propylamine In gas at 69.9℃; Thermodynamic data; δΔGH+(g), var. bases; |
histamine
Conditions | Yield |
---|---|
With ethanol; sodium |
Molecular Structure:
Molecular Formula: C5H9N3
Molecular Weight: 111.1451
IUPAC Name: 2-(1H-Imidazol-5-yl)ethanamine
Synonyms of Histamine (CAS NO.51-45-6): Histamine [USAN] ; 1H-Imidazole-4-ethanamine ; 2-(4-Imidazolyl)ethylamine ; 4-(2-Aminoethyl)-1H-imidazole ; 5-Imidazoleethylamine ; CCRIS 6535 ; EINECS 200-100-6 ; Eramin ; Ergamine ; Ergotidine ; Ethylamine, 2-imidazol-4-yl- ; Free histamine ; HSDB 3338 ; Imidazole, 4-(2-aminoethyl)- ; Imidazole-4-ethylamine ; Istamina ; Istamina [Italian] ; NSC 33792 ; Theramine ; UNII-820484N8I3 ; beta-Aminoethylglyoxaline ; beta-Aminoethylimidazole ; beta-Imidazolyl-4-ethylamine ; 1H-Imidazole-5-ethanamine ; 2-Imidazol-4-ylethylamine
CAS NO: 51-45-6
Classification Code: Histamine Agents ; Histamine Agonists ; Mutation data ; Natural Product ; Neurotransmitter Agents ; Reproductive Effect
Melting point: 83-84 °C
Index of Refraction: 1.567
Molar Refractivity: 31.86 cm3
Molar Volume: 97.4 cm3
Surface Tension: 56 dyne/cm
Density: 1.14 g/cm3
Flash Point: 180.3 °C
Enthalpy of Vaporization: 57.36 kJ/mol
Boiling Point: 331 °C at 760 mmHg
Vapour Pressure: 0.00016 mmHg at 25 °C
Histamine (CAS NO.51-45-6) is derived from the decarboxylation of the amino acid histidine, a reaction catalyzed by the enzyme L-histidine decarboxylase.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LDLo | subcutaneous | 34mg/kg (34mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 185, Pg. 461, 1937. | |
dog | LD50 | intravenous | 7mg/kg (7mg/kg) | CARDIAC: OTHER CHANGES | Indian Veterinary Journal. Vol. 57, Pg. 31, 1980. |
dog | LDLo | subcutaneous | 28500ug/kg (28.5mg/kg) | BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948. |
frog | LDLo | subcutaneous | 1700mg/kg (1700mg/kg) | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948. | |
guinea pig | LD50 | intraperitoneal | 5mg/kg (5mg/kg) | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 736, 1948. | |
guinea pig | LD50 | intravenous | 180ug/kg (0.18mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 45, 1949. | |
guinea pig | LDLo | oral | 200mg/kg (200mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948. |
guinea pig | LDLo | subcutaneous | 8mg/kg (8mg/kg) | Farmaco, Edizione Scientifica. Vol. 9, Pg. 379, 1954. | |
monkey | LDLo | intravenous | 50mg/kg (50mg/kg) | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948. | |
mouse | LD50 | intraperitoneal | 725mg/kg (725mg/kg) | British Journal of Pharmacology and Chemotherapy. Vol. 17, Pg. 137, 1961. | |
mouse | LD50 | intravenous | 385mg/kg (385mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 89, 1979. |
mouse | LD50 | oral | 220mg/kg (220mg/kg) | Japanese Journal of Toxicology. Vol. 4, Pg. 105, 1991. | |
mouse | LD50 | subcutaneous | 2500mg/kg (2500mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: ATAXIA | Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 89, 1979. |
rabbit | LDLo | intravenous | 2mg/kg (2mg/kg) | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 784, 1948. | |
rabbit | LDLo | subcutaneous | 12mg/kg (12mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948. |
rat | LD50 | intravenous | 630mg/kg (630mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 89, 1979. |
rat | LDLo | subcutaneous | 250mg/kg (250mg/kg) | AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 185, Pg. 461, 1937. |
Hazard Codes of Histamine (CAS NO.51-45-6): Xn
Risk Statements: 22-36/37/38-42/43
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
R42/43: May cause sensitization by inhalation and skin contact.
Safety Statements: 22-26-36/37
S22: Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37: Wear suitable protective clothing and gloves.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: MS1050000
F: 3-10-23
HazardClass: 6.1(b)
PackingGroup: III